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Protein

Uridine 5'-monophosphate synthase

Gene

PYRE-F

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Uridine 5'-monophosphate synthase (PYRE-F)
  2. Uridine 5'-monophosphate synthase (PYRE-F)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei305By similarity1

GO - Molecular functioni

GO - Biological processi

  • 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  • 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  • cellular response to phosphate starvation Source: TAIR
  • response to cadmium ion Source: TAIR

Keywordsi

Molecular functionDecarboxylase, Glycosyltransferase, Lyase, Multifunctional enzyme, Transferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BioCyciARA:AT3G54470-MONOMER
MetaCyc:AT3G54470-MONOMER
ReactomeiR-ATH-500753 Pyrimidine biosynthesis
UniPathwayiUPA00070; UER00119
UPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMPdecase
Gene namesi
Name:PYRE-F
Synonyms:UMPS
Ordered Locus Names:At3g54470
ORF Names:T14E10.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G54470
TAIRilocus:504955714 AT3G54470

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001396531 – 476Uridine 5'-monophosphate synthaseAdd BLAST476

Proteomic databases

PaxDbiQ42586
PRIDEiQ42586

Expressioni

Gene expression databases

ExpressionAtlasiQ42586 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi9928, 1 interactor
STRINGi3702.AT3G54470.1

Structurei

3D structure databases

ProteinModelPortaliQ42586
SMRiQ42586
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377 Eukaryota
COG0284 LUCA
COG0461 LUCA
HOGENOMiHOG000213905
KOiK13421
OMAiGIKLHSM
OrthoDBiEOG093602IE
PhylomeDBiQ42586

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
PF00156 Pribosyltran, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit
TIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

Q42586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAMEALILQ LHEIGAVKFG NFKLKSGIFS PVYIDLRLIV SYPSLLTQIS
60 70 80 90 100
QTLISSLPPS ATFDVVCGVP YTALPIATVV SVSNGIPMLM RRKEIKDYGT
110 120 130 140 150
SKAIEGIFEK DQTCLIIEDL VTSGASVLET AAPLRAVGLK VSDAVVLIDR
160 170 180 190 200
QQGGRENLAE NGIKLHSMIM LTDMVRVLKE KGKIEVEVEV NLLKFLEENR
210 220 230 240 250
RVSVPSVEKP KPKPRVLGFK ERSELSKNPT GKKLFDIMLK KETNLCLAAD
260 270 280 290 300
VGTAAELLDI ADKVGPEICL LKTHVDILPD FTPDFGSKLR AIADKHKFLI
310 320 330 340 350
FEDRKFADIG NTVTMQYEGG IFKILEWADI INAHVISGPG IVDGLKLKGM
360 370 380 390 400
PRGRGLLLLA EMSSAGNLAT GDYTAAAVKI ADAHSDFVMG FISVNPASWK
410 420 430 440 450
CGYVYPSMIH ATPGVQMVKG GDALGQQYNT PHSVITERGS DIIIVGRGII
460 470
KAENPAETAH EYRVQGWNAY LEKCSQ
Length:476
Mass (Da):51,850
Last modified:June 6, 2002 - v2
Checksum:iF79AE7992503D928
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186V → E (PubMed:8041358).Curated1
Sequence conflicti186V → E (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71842 mRNA Translation: CAA50686.1
AF276887 Genomic DNA Translation: AAK69440.1
AL138656 Genomic DNA Translation: CAB77567.1
CP002686 Genomic DNA Translation: AEE79235.1
AY140098 mRNA Translation: AAM98239.1
BT006612 mRNA Translation: AAP31956.1
PIRiS46440
T47606
RefSeqiNP_680130.1, NM_148875.5
UniGeneiAt.108

Genome annotation databases

EnsemblPlantsiAT3G54470.1; AT3G54470.1; AT3G54470
GeneIDi824612
GrameneiAT3G54470.1; AT3G54470.1; AT3G54470
KEGGiath:AT3G54470

Similar proteinsi

Entry informationi

Entry nameiUMPS_ARATH
AccessioniPrimary (citable) accession number: Q42586
Secondary accession number(s): Q9M1I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 6, 2002
Last modified: April 25, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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