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Protein

Peroxidase 21

Gene

PER21

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Might function as heat shock-like defense protein. May be implicated in the systemic acquired resistance response.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei66Transition state stabilizerPROSITE-ProRule annotation1
Active sitei70Proton acceptor1
Metal bindingi71Calcium 1PROSITE-ProRule annotation1
Metal bindingi74Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi80Calcium 1PROSITE-ProRule annotation1
Binding sitei167Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi197Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi198Calcium 2PROSITE-ProRule annotation1
Metal bindingi247Calcium 2PROSITE-ProRule annotation1
Metal bindingi250Calcium 2PROSITE-ProRule annotation1
Metal bindingi255Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processBiological rhythms, Hydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G37130-MONOMER

Protein family/group databases

PeroxiBasei240 AtPrx21

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 21 (EC:1.11.1.7)
Short name:
Atperox P21
Alternative name(s):
ATP2a/ATP2b
PRXR5
Gene namesi
Name:PER21
Synonyms:P21
Ordered Locus Names:At2g37130
ORF Names:T2N18.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G37130
TAIRilocus:2061794 AT2G37130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002368729 – 327Peroxidase 21Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 118PROSITE-ProRule annotation
Disulfide bondi72 ↔ 77PROSITE-ProRule annotation
Disulfide bondi124 ↔ 323PROSITE-ProRule annotation
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 231PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ42580
PRIDEiQ42580

Expressioni

Tissue specificityi

Preferentially expressed in roots and leaves, slightly in stems.

Developmental stagei

Up-regulated during leaf development.1 Publication

Inductioni

Late induced after mechanical wounding. Enhanced expression following incompatible bacterial pathogen attack. Expressed under a diurnal rhythm (circadian clock control).4 Publications

Gene expression databases

ExpressionAtlasiQ42580 baseline and differential
GenevisibleiQ42580 AT

Interactioni

Protein-protein interaction databases

BioGridi3633, 1 interactor
IntActiQ42580, 1 interactor
STRINGi3702.AT2G37130.1

Structurei

3D structure databases

ProteinModelPortaliQ42580
SMRiQ42580
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK1D Eukaryota
ENOG410YHIH LUCA
HOGENOMiHOG000237556
InParanoidiQ42580
KOiK00430
OMAiMKTGRRD
OrthoDBiEOG09360GV7
PhylomeDBiQ42580

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q42580-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANAKPFCLL GFFCLLLQLF SIFHIGNGEL EMNYYKESCP KAEEIIRQQV
60 70 80 90 100
ETLYYKHGNT AVSWLRNLFH DCVVKSCDAS LLLETARGVE SEQKSKRSFG
110 120 130 140 150
MRNFKYVKII KDALEKECPS TVSCADIVAL SARDGIVMLK GPKIEMIKTG
160 170 180 190 200
RRDSRGSYLG DVETLIPNHN DSLSSVISTF NSIGIDVEAT VALLGAHSVG
210 220 230 240 250
RVHCVNLVHR LYPTIDPTLD PSYALYLKKR CPSPTPDPNA VLYSRNDRET
260 270 280 290 300
PMVVDNMYYK NIMAHKGLLV IDDELATDPR TAPFVAKMAA DNNYFHEQFS
310 320
RGVRLLSETN PLTGDQGEIR KDCRYVN
Length:327
Mass (Da):36,741
Last modified:November 1, 1996 - v1
Checksum:iD64870D7B8641007
GO

Sequence cautioni

The sequence AAL24415 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177I → L in CAA66961 (Ref. 1) Curated1
Sequence conflicti279P → S in CAA66961 (Ref. 1) Curated1
Sequence conflicti293N → G in CAA66961 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98317 mRNA Translation: CAA66961.1
X98190 mRNA Translation: CAA66863.1
AC006260 Genomic DNA Translation: AAD18146.1
CP002685 Genomic DNA Translation: AEC09354.1
AY087458 mRNA Translation: AAM65003.1
AY059933 mRNA Translation: AAL24415.1 Different initiation.
AY081588 mRNA Translation: AAM10150.1
PIRiH84788
RefSeqiNP_181250.1, NM_129269.4 [Q42580-1]
UniGeneiAt.21472
At.47592

Genome annotation databases

EnsemblPlantsiAT2G37130.1; AT2G37130.1; AT2G37130 [Q42580-1]
GeneIDi818289
GrameneiAT2G37130.1; AT2G37130.1; AT2G37130 [Q42580-1]
KEGGiath:AT2G37130

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPER21_ARATH
AccessioniPrimary (citable) accession number: Q42580
Secondary accession number(s): Q43733, Q93YM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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