Q42577 (NDUS7_ARATH) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 102.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial EC=1.6.5.3 EC=1.6.99.3 | ||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) | ||||
| Taxonomic identifier | 3702 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Protein attributes
| Sequence length | 218 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. |
| Catalytic activity | NADH + ubiquinone = NAD+ + ubiquinol. NADH + acceptor = NAD+ + reduced acceptor. |
| Cofactor | Binds 1 4Fe-4S cluster Potential. |
| Subunit structure | Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme. |
| Subcellular location | |
| Sequence similarities | Belongs to the complex I 20 kDa subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Respiratory chain Transport |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding NAD Ubiquinone |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial respiratory chain complex I Inferred from direct assay. Source: TAIR |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW NADH dehydrogenase (ubiquinone) activityInferred from electronic annotation. Source: EC quinone bindingInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from direct assay. Source: TAIR |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | |||||||
| Chain | ? – 218 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | PRO_0000020033 | ||||||
Sites | |||||||||
| Metal binding | 93 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 94 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 158 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 188 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The plant mitochondrial 22 kDa (PSST) subunit of respiratory chain complex I is encoded by a nuclear gene with enhanced transcript levels in flowers." Heiser V., Grohmann L., Brennicke A. Plant Mol. Biol. 31:1195-1204(1996) [PubMed: 8914535] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. C24. |
| [2] | "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana." Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. Fransz P.F.Nature 408:823-826(2000) [PubMed: 11130714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [3] | The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia. |
| [4] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [5] | "Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins." Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H. Plant Cell 16:241-256(2004) [PubMed: 14671022] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Strain: cv. Landsberg erecta. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X84078 mRNA. Translation: CAA58887.1. AL163814 Genomic DNA. Translation: CAB87695.1. CP002688 Genomic DNA. Translation: AED91719.1. AF428300 mRNA. Translation: AAL16132.1. AY056182 mRNA. Translation: AAL07031.1. AY099848 mRNA. Translation: AAM20699.1. AY128912 mRNA. Translation: AAM91312.1. AY085120 mRNA. Translation: AAM61674.1. |
| IPI | IPI00530636. |
| PIR | S52286. |
| RefSeq | NP_196738.1. NM_121215.3. |
| UniGene | At.23410. At.75009. |
3D structure databases | |
| ProteinModelPortal | Q42577. |
| SMR | Q42577. Positions 65-212. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q42577. 2 interactions. |
| STRING | Q42577. |
Protein family/group databases | |
| TCDB | 3.D.1.6.3. H+ or Na+-translocating NADH dehydrogenase (NDH) family. |
Proteomic databases | |
| PRIDE | Q42577. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblPlants | AT5G11770.1; AT5G11770.1; AT5G11770. |
| GeneID | 831049. |
| GenomeReviews | Gene locus AT5G11770 in contig BA000015_GR. |
| KEGG | ath:AT5G11770. |
| NMPDR | fig|3702.1.peg.23316. |
Organism-specific databases | |
| GeneFarm | 1829. |
| TAIR | At5g11770. |
Phylogenomic databases | |
| eggNOG | KOG1687. |
| HOGENOM | HBG553221. |
| InParanoid | Q42577. |
| OMA | NWARKGS. |
| PhylomeDB | Q42577. |
| ProtClustDB | CLSN2686797. |
Enzyme and pathway databases | |
| BioCyc | ARA:AT5G11770-MONOMER. MetaCyc:AT5G11770-MONOMER. |
Gene expression databases | |
| ArrayExpress | Q42577. |
| Genevestigator | Q42577. |
| GermOnline | AT5G11770. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR006137. NADH_UbQ_OxRdtase-like_20kDa. IPR006138. NADH_UQ_OxRdtase_20Kd_su. IPR014406. NiFe-hyd_3_ssu/Q_oxred_NuoB. [Graphical view] |
| Gene3D | G3DSA:3.40.50.700. G3DSA:3.40.50.700. 1 hit. |
| KO | K03940. |
| PANTHER | PTHR11995. NiFe_hyd_3_ssu/Q_oxred_NuoB. 1 hit. |
| Pfam | PF01058. Oxidored_q6. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01957. NuoB_fam. 1 hit. |
| PROSITE | PS01150. COMPLEX1_20K. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NDUS7_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q42577 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with