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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

At5g11770

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi94Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi158Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi188Iron-sulfur (4Fe-4S)Sequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

BioCyciARA:AT5G11770-MONOMER.
MetaCyc:AT5G11770-MONOMER.
ReactomeiR-ATH-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Gene namesi
Ordered Locus Names:At5g11770
ORF Names:T22P22_160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G11770.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: TAIR
  • mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020033? – 218NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ42577.
PRIDEiQ42577.

PTM databases

iPTMnetiQ42577.

Expressioni

Gene expression databases

GenevisibleiQ42577. AT.

Interactioni

Subunit structurei

Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

Protein-protein interaction databases

BioGridi16327. 1 interactor.
IntActiQ42577. 2 interactors.
STRINGi3702.AT5G11770.1.

Structurei

3D structure databases

ProteinModelPortaliQ42577.
SMRiQ42577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1687. Eukaryota.
COG0377. LUCA.
HOGENOMiHOG000228249.
InParanoidiQ42577.
KOiK03940.
OMAiDWRLFEP.
OrthoDBiEOG09360Q3Q.
PhylomeDBiQ42577.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
HAMAPiMF_01356. NDH1_NuoB. 1 hit.
InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamiPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
PROSITEiPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMITRNTAT RLPLLLQSQR AVAAASVSHL HTSLPALSPS TSPTSYTRPG
60 70 80 90 100
PPSTSPPPPG LSKAAEFVIS KVDDLMNWAR TGSIWPMTFG LACCAVEMMH
110 120 130 140 150
TGAARYDLDR FGIIFRPSPR QSDCMIVAGT LTNKMAPALR KVYDQMPEPR
160 170 180 190 200
WVISMGSCAN GGGYYHYSYS VVRGCDRIVP VDIYVPGCPP TAEALLYGLL
210
QLQKKINRRK DFLHWWNK
Length:218
Mass (Da):24,044
Last modified:November 1, 1996 - v1
Checksum:iD4FC0E15A4029908
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84078 mRNA. Translation: CAA58887.1.
AL163814 Genomic DNA. Translation: CAB87695.1.
CP002688 Genomic DNA. Translation: AED91719.1.
AF428300 mRNA. Translation: AAL16132.1.
AY056182 mRNA. Translation: AAL07031.1.
AY099848 mRNA. Translation: AAM20699.1.
AY128912 mRNA. Translation: AAM91312.1.
AY085120 mRNA. Translation: AAM61674.1.
PIRiS52286.
RefSeqiNP_196738.1. NM_121215.4.
UniGeneiAt.23410.

Genome annotation databases

EnsemblPlantsiAT5G11770.1; AT5G11770.1; AT5G11770.
GeneIDi831049.
GrameneiAT5G11770.1; AT5G11770.1; AT5G11770.
KEGGiath:AT5G11770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84078 mRNA. Translation: CAA58887.1.
AL163814 Genomic DNA. Translation: CAB87695.1.
CP002688 Genomic DNA. Translation: AED91719.1.
AF428300 mRNA. Translation: AAL16132.1.
AY056182 mRNA. Translation: AAL07031.1.
AY099848 mRNA. Translation: AAM20699.1.
AY128912 mRNA. Translation: AAM91312.1.
AY085120 mRNA. Translation: AAM61674.1.
PIRiS52286.
RefSeqiNP_196738.1. NM_121215.4.
UniGeneiAt.23410.

3D structure databases

ProteinModelPortaliQ42577.
SMRiQ42577.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16327. 1 interactor.
IntActiQ42577. 2 interactors.
STRINGi3702.AT5G11770.1.

Protein family/group databases

TCDBi3.D.1.6.3. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

PTM databases

iPTMnetiQ42577.

Proteomic databases

PaxDbiQ42577.
PRIDEiQ42577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G11770.1; AT5G11770.1; AT5G11770.
GeneIDi831049.
GrameneiAT5G11770.1; AT5G11770.1; AT5G11770.
KEGGiath:AT5G11770.

Organism-specific databases

TAIRiAT5G11770.

Phylogenomic databases

eggNOGiKOG1687. Eukaryota.
COG0377. LUCA.
HOGENOMiHOG000228249.
InParanoidiQ42577.
KOiK03940.
OMAiDWRLFEP.
OrthoDBiEOG09360Q3Q.
PhylomeDBiQ42577.

Enzyme and pathway databases

BioCyciARA:AT5G11770-MONOMER.
MetaCyc:AT5G11770-MONOMER.
ReactomeiR-ATH-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ42577.

Gene expression databases

GenevisibleiQ42577. AT.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
HAMAPiMF_01356. NDH1_NuoB. 1 hit.
InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR006138. NADH_UQ_OxRdtase_20Kd_su.
[Graphical view]
PfamiPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
PROSITEiPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUS7_ARATH
AccessioniPrimary (citable) accession number: Q42577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.