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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

At5g11770

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi94Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi158Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi188Iron-sulfur (4Fe-4S)Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

BioCyciARA:AT5G11770-MONOMER
MetaCyc:AT5G11770-MONOMER
ReactomeiR-ATH-6799198 Complex I biogenesis

Protein family/group databases

TCDBi3.D.1.6.3 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Gene namesi
Ordered Locus Names:At5g11770
ORF Names:T22P22_160
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G11770
TAIRilocus:2181885 AT5G11770

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020033? – 218NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ42577
PRIDEiQ42577

PTM databases

iPTMnetiQ42577

Expressioni

Gene expression databases

ExpressionAtlasiQ42577 baseline and differential
GenevisibleiQ42577 AT

Interactioni

Subunit structurei

Complex I is composed of at least 49 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

Protein-protein interaction databases

BioGridi16327, 1 interactor
IntActiQ42577, 2 interactors
STRINGi3702.AT5G11770.1

Structurei

3D structure databases

ProteinModelPortaliQ42577
SMRiQ42577
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1687 Eukaryota
COG0377 LUCA
HOGENOMiHOG000228249
InParanoidiQ42577
KOiK03940
OMAiEMMTTGA
OrthoDBiEOG09360Q3Q
PhylomeDBiQ42577

Family and domain databases

HAMAPiMF_01356 NDH1_NuoB, 1 hit
InterProiView protein in InterPro
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR006138 NADH_UQ_OxRdtase_20Kd_su
PfamiView protein in Pfam
PF01058 Oxidored_q6, 1 hit
TIGRFAMsiTIGR01957 nuoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01150 COMPLEX1_20K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMITRNTAT RLPLLLQSQR AVAAASVSHL HTSLPALSPS TSPTSYTRPG
60 70 80 90 100
PPSTSPPPPG LSKAAEFVIS KVDDLMNWAR TGSIWPMTFG LACCAVEMMH
110 120 130 140 150
TGAARYDLDR FGIIFRPSPR QSDCMIVAGT LTNKMAPALR KVYDQMPEPR
160 170 180 190 200
WVISMGSCAN GGGYYHYSYS VVRGCDRIVP VDIYVPGCPP TAEALLYGLL
210
QLQKKINRRK DFLHWWNK
Length:218
Mass (Da):24,044
Last modified:November 1, 1996 - v1
Checksum:iD4FC0E15A4029908
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84078 mRNA Translation: CAA58887.1
AL163814 Genomic DNA Translation: CAB87695.1
CP002688 Genomic DNA Translation: AED91719.1
AF428300 mRNA Translation: AAL16132.1
AY056182 mRNA Translation: AAL07031.1
AY099848 mRNA Translation: AAM20699.1
AY128912 mRNA Translation: AAM91312.1
AY085120 mRNA Translation: AAM61674.1
PIRiS52286
RefSeqiNP_196738.1, NM_121215.4
UniGeneiAt.23410

Genome annotation databases

EnsemblPlantsiAT5G11770.1; AT5G11770.1; AT5G11770
GeneIDi831049
GrameneiAT5G11770.1; AT5G11770.1; AT5G11770
KEGGiath:AT5G11770

Similar proteinsi

Entry informationi

Entry nameiNDUS7_ARATH
AccessioniPrimary (citable) accession number: Q42577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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