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Protein

Cell division protein FtsZ homolog 1, chloroplastic

Gene

FTSZ1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits GTPase activity. Component of the plastid division machinery that forms a contractile ring at the division site. Required for plastid division in a dose-dependent manner. Involved in blue light-induced chloroplast movements. May regulate thylakoid development.9 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei201GTPBy similarity1
Binding sitei205GTPBy similarity1
Binding sitei249GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 87GTPBy similarity5
Nucleotide bindingi170 – 172GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • protein self-association Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chloroplast fission Source: TAIR
  • chloroplast organization Source: UniProtKB
  • chloroplast relocation Source: UniProtKB
  • microtubule-based process Source: InterPro
  • plastid fission Source: TAIR
  • response to blue light Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ homolog 1, chloroplastic
Short name:
AtFtsZ1
Short name:
AtFtsZ1-1
Short name:
Chloroplast FtsZ
Short name:
CpFtsZ
Alternative name(s):
Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 10
Protein PLASTID MOVEMENT IMPAIRED4
Gene namesi
Name:FTSZ1
Synonyms:ARC10, FTSZ1-1, PMI4
Ordered Locus Names:At5g55280
ORF Names:MCO15.23
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G55280.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast stroma Source: UniProtKB
  • chloroplast thylakoid membrane Source: UniProtKB-SubCell
  • microtubule Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Thylakoid

Pathology & Biotechi

Disruption phenotypei

Highly heterogeneous chloroplast population with giant chloroplasts and some smaller. Impaired chloroplast division, some green cells with one single big chloroplast. Abnormal thylakoids.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi159D → N: Forms long filaments with impaired midplastidial localization, heterogeneous chloroplast population, one greatly enlarged with numerous smaller chloroplasts per cell. 1 Publication1
Mutagenesisi267G → R in pmi4; reduced accumulation with impaired midplastidial localization in rings and filaments, giant chloroplasts, and altered chloroplast movements in response to blue light. 2 Publications1
Mutagenesisi275D → A: Impaired GTPase activity. 1 Publication1
Mutagenesisi298R → Q: Reduced accumulation, heterogeneous chloroplast population. 1 Publication1
Mutagenesisi366G → A in arc10; forms long filaments, heterogeneous chloroplast population, one greatly enlarged with numerous smaller chloroplasts per cell. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 66ChloroplastCombined sourcesAdd BLAST66
ChainiPRO_000001030667 – 433Cell division protein FtsZ homolog 1, chloroplasticAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ42545.
PRIDEiQ42545.

Expressioni

Tissue specificityi

In pollen grain, restricted to plastids of vegetative cells. Also present in pollen tubes plastids.1 Publication

Gene expression databases

GenevisibleiQ42545. AT.

Interactioni

Subunit structurei

Aggregates to form a contractile ring-like structure. This aggregation is regulated in midchloroplast stroma by MIND1 (repressor) and MINE1 (promoter). Self-interacts and binds to FTSZ2-1 in heteropolymers to form two morphologically distinct types of filaments, termed type-I (smooth filaments) and type-II (rough filaments), in a GTP-dependent manner. Interacts with ARC3. Part of a complex made of ARC3, ARC6, FTSZ1 and FTSZ2.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-2131124,EBI-2131124
ARC6Q9FIG92EBI-2131124,EBI-2000800
FTSZ2-2Q9LXJ06EBI-2131124,EBI-2430270

GO - Molecular functioni

  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi20865. 5 interactors.
IntActiQ42545. 5 interactors.
MINTiMINT-4507116.
STRINGi3702.AT5G55280.1.

Structurei

3D structure databases

ProteinModelPortaliQ42545.
SMRiQ42545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IEJ4. Eukaryota.
COG0206. LUCA.
HOGENOMiHOG000049094.
InParanoidiQ42545.
KOiK03531.
OMAiGMAMMGI.
OrthoDBiEOG09360HE6.
PhylomeDBiQ42545.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIIPLAQLN ELTISSSSSS FLTKSISSHS LHSSCICASS RISQFRGGFS
60 70 80 90 100
KRRSDSTRSK SMRLRCSFSP MESARIKVIG VGGGGNNAVN RMISSGLQSV
110 120 130 140 150
DFYAINTDSQ ALLQSSAENP LQIGELLTRG LGTGGNPLLG EQAAEESKDA
160 170 180 190 200
IANALKGSDL VFITAGMGGG TGSGAAPVVA QISKDAGYLT VGVVTYPFSF
210 220 230 240 250
EGRKRSLQAL EAIEKLQKNV DTLIVIPNDR LLDIADEQTP LQDAFLLADD
260 270 280 290 300
VLRQGVQGIS DIITIPGLVN VDFADVKAVM KDSGTAMLGV GVSSSKNRAE
310 320 330 340 350
EAAEQATLAP LIGSSIQSAT GVVYNITGGK DITLQEVNRV SQVVTSLADP
360 370 380 390 400
SANIIFGAVV DDRYTGEIHV TIIATGFSQS FQKTLLTDPR AAKLLDKMGS
410 420 430
SGQQENKGMS LPHQKQSPST ISTKSSSPRR LFF
Length:433
Mass (Da):45,565
Last modified:July 11, 2002 - v2
Checksum:i82C942D597171EDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115S → F in AAA82068 (PubMed:7637778).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39877 mRNA. Translation: AAA82068.1.
AB010071 Genomic DNA. Translation: BAB08597.1.
CP002688 Genomic DNA. Translation: AED96609.1.
AY034992 mRNA. Translation: AAK59497.1.
AY113896 mRNA. Translation: AAM44944.1.
RefSeqiNP_200339.1. NM_124910.6.
UniGeneiAt.1538.

Genome annotation databases

EnsemblPlantsiAT5G55280.1; AT5G55280.1; AT5G55280.
GeneIDi835621.
GrameneiAT5G55280.1; AT5G55280.1; AT5G55280.
KEGGiath:AT5G55280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39877 mRNA. Translation: AAA82068.1.
AB010071 Genomic DNA. Translation: BAB08597.1.
CP002688 Genomic DNA. Translation: AED96609.1.
AY034992 mRNA. Translation: AAK59497.1.
AY113896 mRNA. Translation: AAM44944.1.
RefSeqiNP_200339.1. NM_124910.6.
UniGeneiAt.1538.

3D structure databases

ProteinModelPortaliQ42545.
SMRiQ42545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20865. 5 interactors.
IntActiQ42545. 5 interactors.
MINTiMINT-4507116.
STRINGi3702.AT5G55280.1.

Proteomic databases

PaxDbiQ42545.
PRIDEiQ42545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G55280.1; AT5G55280.1; AT5G55280.
GeneIDi835621.
GrameneiAT5G55280.1; AT5G55280.1; AT5G55280.
KEGGiath:AT5G55280.

Organism-specific databases

TAIRiAT5G55280.

Phylogenomic databases

eggNOGiENOG410IEJ4. Eukaryota.
COG0206. LUCA.
HOGENOMiHOG000049094.
InParanoidiQ42545.
KOiK03531.
OMAiGMAMMGI.
OrthoDBiEOG09360HE6.
PhylomeDBiQ42545.

Miscellaneous databases

PROiQ42545.

Gene expression databases

GenevisibleiQ42545. AT.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSZ1_ARATH
AccessioniPrimary (citable) accession number: Q42545
Secondary accession number(s): Q9FLN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2002
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.