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Protein

Cell division protein FtsZ homolog 1, chloroplastic

Gene

FTSZ1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits GTPase activity. Component of the plastid division machinery that forms a contractile ring at the division site. Required for plastid division in a dose-dependent manner. Involved in blue light-induced chloroplast movements. May regulate thylakoid development.9 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei201GTPBy similarity1
Binding sitei205GTPBy similarity1
Binding sitei249GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 87GTPBy similarity5
Nucleotide bindingi170 – 172GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chloroplast fission Source: TAIR
  • chloroplast organization Source: UniProtKB
  • chloroplast relocation Source: UniProtKB
  • microtubule-based process Source: InterPro
  • plastid fission Source: TAIR
  • response to blue light Source: UniProtKB

Keywordsi

Biological processCell cycle
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ homolog 1, chloroplastic
Short name:
AtFtsZ1
Short name:
AtFtsZ1-1
Short name:
Chloroplast FtsZ
Short name:
CpFtsZ
Alternative name(s):
Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 10
Protein PLASTID MOVEMENT IMPAIRED4
Gene namesi
Name:FTSZ1
Synonyms:ARC10, FTSZ1-1, PMI4
Ordered Locus Names:At5g55280
ORF Names:MCO15.23
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G55280
TAIRilocus:2161610 AT5G55280

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Thylakoid

Pathology & Biotechi

Disruption phenotypei

Highly heterogeneous chloroplast population with giant chloroplasts and some smaller. Impaired chloroplast division, some green cells with one single big chloroplast. Abnormal thylakoids.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi159D → N: Forms long filaments with impaired midplastidial localization, heterogeneous chloroplast population, one greatly enlarged with numerous smaller chloroplasts per cell. 1 Publication1
Mutagenesisi267G → R in pmi4; reduced accumulation with impaired midplastidial localization in rings and filaments, giant chloroplasts, and altered chloroplast movements in response to blue light. 2 Publications1
Mutagenesisi275D → A: Impaired GTPase activity. 1 Publication1
Mutagenesisi298R → Q: Reduced accumulation, heterogeneous chloroplast population. 1 Publication1
Mutagenesisi366G → A in arc10; forms long filaments, heterogeneous chloroplast population, one greatly enlarged with numerous smaller chloroplasts per cell. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 66ChloroplastCombined sourcesAdd BLAST66
ChainiPRO_000001030667 – 433Cell division protein FtsZ homolog 1, chloroplasticAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ42545
PRIDEiQ42545

PTM databases

iPTMnetiQ42545

Expressioni

Tissue specificityi

In pollen grain, restricted to plastids of vegetative cells. Also present in pollen tubes plastids.1 Publication

Gene expression databases

ExpressionAtlasiQ42545 baseline and differential
GenevisibleiQ42545 AT

Interactioni

Subunit structurei

Aggregates to form a contractile ring-like structure. This aggregation is regulated in midchloroplast stroma by MIND1 (repressor) and MINE1 (promoter). Self-interacts and binds to FTSZ2-1 in heteropolymers to form two morphologically distinct types of filaments, termed type-I (smooth filaments) and type-II (rough filaments), in a GTP-dependent manner. Interacts with ARC3. Part of a complex made of ARC3, ARC6, FTSZ1 and FTSZ2.8 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi20865, 5 interactors
IntActiQ42545, 5 interactors
MINTiQ42545
STRINGi3702.AT5G55280.1

Structurei

3D structure databases

ProteinModelPortaliQ42545
SMRiQ42545
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IEJ4 Eukaryota
COG0206 LUCA
HOGENOMiHOG000049094
InParanoidiQ42545
KOiK03531
OMAiMRAVKGI
OrthoDBiEOG09360HE6
PhylomeDBiQ42545

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIIPLAQLN ELTISSSSSS FLTKSISSHS LHSSCICASS RISQFRGGFS
60 70 80 90 100
KRRSDSTRSK SMRLRCSFSP MESARIKVIG VGGGGNNAVN RMISSGLQSV
110 120 130 140 150
DFYAINTDSQ ALLQSSAENP LQIGELLTRG LGTGGNPLLG EQAAEESKDA
160 170 180 190 200
IANALKGSDL VFITAGMGGG TGSGAAPVVA QISKDAGYLT VGVVTYPFSF
210 220 230 240 250
EGRKRSLQAL EAIEKLQKNV DTLIVIPNDR LLDIADEQTP LQDAFLLADD
260 270 280 290 300
VLRQGVQGIS DIITIPGLVN VDFADVKAVM KDSGTAMLGV GVSSSKNRAE
310 320 330 340 350
EAAEQATLAP LIGSSIQSAT GVVYNITGGK DITLQEVNRV SQVVTSLADP
360 370 380 390 400
SANIIFGAVV DDRYTGEIHV TIIATGFSQS FQKTLLTDPR AAKLLDKMGS
410 420 430
SGQQENKGMS LPHQKQSPST ISTKSSSPRR LFF
Length:433
Mass (Da):45,565
Last modified:July 11, 2002 - v2
Checksum:i82C942D597171EDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115S → F in AAA82068 (PubMed:7637778).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39877 mRNA Translation: AAA82068.1
AB010071 Genomic DNA Translation: BAB08597.1
CP002688 Genomic DNA Translation: AED96609.1
AY034992 mRNA Translation: AAK59497.1
AY113896 mRNA Translation: AAM44944.1
RefSeqiNP_200339.1, NM_124910.6
UniGeneiAt.1538

Genome annotation databases

EnsemblPlantsiAT5G55280.1; AT5G55280.1; AT5G55280
GeneIDi835621
GrameneiAT5G55280.1; AT5G55280.1; AT5G55280
KEGGiath:AT5G55280

Similar proteinsi

Entry informationi

Entry nameiFTSZ1_ARATH
AccessioniPrimary (citable) accession number: Q42545
Secondary accession number(s): Q9FLN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2002
Last modified: April 25, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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