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Protein

Ubiquitin-conjugating enzyme E2 13

Gene

UBC13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • protein polyubiquitination Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 13 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 13
Ubiquitin carrier protein 13
Ubiquitin-protein ligase 13
Gene namesi
Name:UBC13
Ordered Locus Names:At3g46460
ORF Names:F18L15.180
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRilocus:2078231. AT3G46460.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000825872 – 166Ubiquitin-conjugating enzyme E2 13Add BLAST165

Proteomic databases

PaxDbiQ42541.

Expressioni

Inductioni

Up-regulated by syringolin, a cell death-inducing chemical.1 Publication

Gene expression databases

ExpressionAtlasiQ42541. baseline and differential.
GenevisibleiQ42541. AT.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi9116. 1 interactor.
STRINGi3702.AT3G46460.1.

Structurei

3D structure databases

ProteinModelPortaliQ42541.
SMRiQ42541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0425. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000233454.
InParanoidiQ42541.
KOiK10575.
OMAiMINDDCK.
OrthoDBiEOG09360QV1.
PhylomeDBiQ42541.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQACLLLQ KQLKDLCKHP VDGFSAGLVD EKNIFEWSVT IIGPPDTLYE
60 70 80 90 100
GGFFYAIMSF PQNYPNSPPT VRFTSDIWHP NVYPDGRVCI SILHPPGDDP
110 120 130 140 150
SGYELASERW TPVHTVESIM LSIISMLSGP NDESPANVEA AKEWREKRDE
160
FKKKVSRCVR KSQEMF
Length:166
Mass (Da):18,822
Last modified:November 1, 1996 - v1
Checksum:iDCC26424275F275B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33758 Genomic DNA. Translation: AAC49322.1.
DQ027027 mRNA. Translation: AAY44853.1.
AL133298 Genomic DNA. Translation: CAB62037.1.
CP002686 Genomic DNA. Translation: AEE78162.1.
AY050368 mRNA. Translation: AAK91385.1.
AY094040 mRNA. Translation: AAM16196.1.
PIRiT45703.
RefSeqiNP_566884.1. NM_114513.6.
UniGeneiAt.24542.

Genome annotation databases

EnsemblPlantsiAT3G46460.1; AT3G46460.1; AT3G46460.
GeneIDi823796.
GrameneiAT3G46460.1; AT3G46460.1; AT3G46460.
KEGGiath:AT3G46460.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33758 Genomic DNA. Translation: AAC49322.1.
DQ027027 mRNA. Translation: AAY44853.1.
AL133298 Genomic DNA. Translation: CAB62037.1.
CP002686 Genomic DNA. Translation: AEE78162.1.
AY050368 mRNA. Translation: AAK91385.1.
AY094040 mRNA. Translation: AAM16196.1.
PIRiT45703.
RefSeqiNP_566884.1. NM_114513.6.
UniGeneiAt.24542.

3D structure databases

ProteinModelPortaliQ42541.
SMRiQ42541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9116. 1 interactor.
STRINGi3702.AT3G46460.1.

Proteomic databases

PaxDbiQ42541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G46460.1; AT3G46460.1; AT3G46460.
GeneIDi823796.
GrameneiAT3G46460.1; AT3G46460.1; AT3G46460.
KEGGiath:AT3G46460.

Organism-specific databases

AraportiAT3G46460.
TAIRilocus:2078231. AT3G46460.

Phylogenomic databases

eggNOGiKOG0425. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000233454.
InParanoidiQ42541.
KOiK10575.
OMAiMINDDCK.
OrthoDBiEOG09360QV1.
PhylomeDBiQ42541.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiPR:Q42541.

Gene expression databases

ExpressionAtlasiQ42541. baseline and differential.
GenevisibleiQ42541. AT.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBC13_ARATH
AccessioniPrimary (citable) accession number: Q42541
Secondary accession number(s): Q4TYZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

This protein has been named UBC13 according to the nomenclature proposed in PubMed:16339806, but it is not the same as the UBC13 described in several publications that correspond to the protein named UBC35 in our nomenclature.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.