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Protein

Ubiquitin-conjugating enzyme E2 13

Gene

UBC13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation.1 Publication

Caution

This protein has been named UBC13 according to the nomenclature proposed in PubMed:16339806, but it is not the same as the UBC13 described in several publications that correspond to the protein named UBC35 in our nomenclature.Curated

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • protein polyubiquitination Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 13 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 13
Ubiquitin carrier protein 13
Ubiquitin-protein ligase 13
Gene namesi
Name:UBC13
Ordered Locus Names:At3g46460
ORF Names:F18L15.180
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G46460
TAIRilocus:2078231 AT3G46460

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825871 – 166Ubiquitin-conjugating enzyme E2 13Add BLAST166

Proteomic databases

PaxDbiQ42541
PRIDEiQ42541

Expressioni

Inductioni

Up-regulated by syringolin, a cell death-inducing chemical.1 Publication

Gene expression databases

ExpressionAtlasiQ42541 baseline and differential
GenevisibleiQ42541 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi9116, 1 interactor
STRINGi3702.AT3G46460.1

Structurei

3D structure databases

ProteinModelPortaliQ42541
SMRiQ42541
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0425 Eukaryota
COG5078 LUCA
HOGENOMiHOG000233454
InParanoidiQ42541
KOiK10575
OMAiPKMQFTC
OrthoDBiEOG09360QV1
PhylomeDBiQ42541

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q42541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQACLLLQ KQLKDLCKHP VDGFSAGLVD EKNIFEWSVT IIGPPDTLYE
60 70 80 90 100
GGFFYAIMSF PQNYPNSPPT VRFTSDIWHP NVYPDGRVCI SILHPPGDDP
110 120 130 140 150
SGYELASERW TPVHTVESIM LSIISMLSGP NDESPANVEA AKEWREKRDE
160
FKKKVSRCVR KSQEMF
Length:166
Mass (Da):18,822
Last modified:November 1, 1996 - v1
Checksum:iDCC26424275F275B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33758 Genomic DNA Translation: AAC49322.1
DQ027027 mRNA Translation: AAY44853.1
AL133298 Genomic DNA Translation: CAB62037.1
CP002686 Genomic DNA Translation: AEE78162.1
AY050368 mRNA Translation: AAK91385.1
AY094040 mRNA Translation: AAM16196.1
PIRiT45703
RefSeqiNP_566884.1, NM_114513.6
UniGeneiAt.24542

Genome annotation databases

EnsemblPlantsiAT3G46460.1; AT3G46460.1; AT3G46460
GeneIDi823796
GrameneiAT3G46460.1; AT3G46460.1; AT3G46460
KEGGiath:AT3G46460

Similar proteinsi

Entry informationi

Entry nameiUBC13_ARATH
AccessioniPrimary (citable) accession number: Q42541
Secondary accession number(s): Q4TYZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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