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Q42540

- UBC7_ARATH

UniProt

Q42540 - UBC7_ARATH

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Protein
Ubiquitin-conjugating enzyme E2 7
Gene
UBC7, At5g59300, MNC17.21
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation.1 Publication

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G59300-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 7 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein 7
Ubiquitin-protein ligase 7
Gene namesi
Name:UBC7
Ordered Locus Names:At5g59300
ORF Names:MNC17.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G59300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Ubiquitin-conjugating enzyme E2 7
PRO_0000082586Add
BLAST

Proteomic databases

PaxDbiQ42540.
PRIDEiQ42540.

Expressioni

Gene expression databases

GenevestigatoriQ42540.

Structurei

3D structure databases

ProteinModelPortaliQ42540.
SMRiQ42540. Positions 5-164.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000233454.
InParanoidiQ42540.
KOiK10575.
PhylomeDBiQ42540.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42540-1 [UniParc]FASTAAdd to Basket

« Hide

MASQASLLLQ KQLKDLCKHP VDGFSAGLVD EKNIFEWSVT IIGPPDTLYE    50
GGFFNAIMTF PQNYPNSPPT VRFTSDMWHP NVYSDGRVCI SILHPPGDDP 100
SGYELASERW TPVHTVESIM LSIISMLSGP NDESPANVEA AKEWRDKRDE 150
FKKKVSRCVR KSQEMF 166
Length:166
Mass (Da):18,722
Last modified:November 1, 1996 - v1
Checksum:i967EF672ADBD6891
GO

Sequence cautioni

The sequence AAL86003.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAO64200.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AED97168.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33757 Genomic DNA. Translation: AAC49321.1.
AB016890 Genomic DNA. Translation: BAB09775.1.
CP002688 Genomic DNA. Translation: AED97168.1. Different initiation.
AY080733 mRNA. Translation: AAL86003.1. Different initiation.
BT005798 mRNA. Translation: AAO64200.1. Different initiation.
PIRiS71209.
RefSeqiNP_568902.2. NM_125320.2.
UniGeneiAt.43359.

Genome annotation databases

EnsemblPlantsiAT5G59300.1; AT5G59300.1; AT5G59300.
GeneIDi836048.
KEGGiath:AT5G59300.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33757 Genomic DNA. Translation: AAC49321.1 .
AB016890 Genomic DNA. Translation: BAB09775.1 .
CP002688 Genomic DNA. Translation: AED97168.1 . Different initiation.
AY080733 mRNA. Translation: AAL86003.1 . Different initiation.
BT005798 mRNA. Translation: AAO64200.1 . Different initiation.
PIRi S71209.
RefSeqi NP_568902.2. NM_125320.2.
UniGenei At.43359.

3D structure databases

ProteinModelPortali Q42540.
SMRi Q42540. Positions 5-164.
ModBasei Search...

Proteomic databases

PaxDbi Q42540.
PRIDEi Q42540.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G59300.1 ; AT5G59300.1 ; AT5G59300 .
GeneIDi 836048.
KEGGi ath:AT5G59300.

Organism-specific databases

TAIRi AT5G59300.

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000233454.
InParanoidi Q42540.
KOi K10575.
PhylomeDBi Q42540.

Enzyme and pathway databases

UniPathwayi UPA00143 .
BioCyci ARA:AT5G59300-MONOMER.

Gene expression databases

Genevestigatori Q42540.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Arabidopsis thaliana UBC7/13/14 genes encode a family of multiubiquitin chain-forming E2 enzymes."
    van Nocker S., Walker J.M., Vierstra R.D.
    J. Biol. Chem. 271:12150-12158(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: cv. Columbia.
    Tissue: Seedling.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones."
    Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:379-391(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiUBC7_ARATH
AccessioniPrimary (citable) accession number: Q42540
Secondary accession number(s): F4KHV0, Q8RXQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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