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Protein

Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplastic

Gene

BCCP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

  • acetyl-CoA carboxylase activity Source: TAIR

GO - Biological processi

  • fatty acid biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Biotin

Enzyme and pathway databases

BioCyciARA:AT5G16390-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplastic
Short name:
AtBCCP1
Short name:
BCCP-1
Gene namesi
Name:BCCP1
Synonyms:CAC1
Ordered Locus Names:At5g16390
ORF Names:MQK4.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G16390.

Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: InterPro
  • chloroplast Source: TAIR
  • chloroplast envelope Source: TAIR
  • chloroplast stroma Source: TAIR
  • plastid Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 82ChloroplastSequence analysisAdd BLAST82
ChainiPRO_000000283183 – 280Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplasticAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

PaxDbiQ42533.

Expressioni

Tissue specificityi

Present in developing tissues from roots, leaves, flowers, siliques and seeds (at protein level).2 Publications

Gene expression databases

ExpressionAtlasiQ42533. baseline and differential.
GenevisibleiQ42533. AT.

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).

Protein-protein interaction databases

BioGridi16776. 1 interactor.
DIPiDIP-58514N.
MINTiMINT-8062366.
STRINGi3702.AT5G16390.1.

Structurei

3D structure databases

ProteinModelPortaliQ42533.
SMRiQ42533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 279Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Contains 1 biotinyl-binding domain.PROSITE-ProRule annotationCurated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IXUZ. Eukaryota.
COG0511. LUCA.
HOGENOMiHOG000008876.
InParanoidiQ42533.
KOiK02160.
OMAiTSSHFPI.
OrthoDBiEOG09360PRH.
PhylomeDBiQ42533.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q42533-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSSFSVTS PAAAASVYAV TQTSSHFPIQ NRSRRVSFRL SAKPKLRFLS
60 70 80 90 100
KPSRSSYPVV KAQSNKVSTG ASSNAAKVDG PSSAEGKEKN SLKESSASSP
110 120 130 140 150
ELATEESISE FLTQVTTLVK LVDSRDIVEL QLKQLDCELV IRKKEALPQP
160 170 180 190 200
QAPASYVMMQ QPNQPSYAQQ MAPPAAPAAA APAPSTPASL PPPSPPTPAK
210 220 230 240 250
SSLPTVKSPM AGTFYRSPAP GEPPFIKVGD KVQKGQVLCI VEAMKLMNEI
260 270 280
ESDHTGTVVD IVAEDGKPVS LDTPLFVVQP
Length:280
Mass (Da):29,613
Last modified:November 2, 2001 - v2
Checksum:iF2580372B92A257A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267 – 280KPVSL…FVVQP → SLSASTLLCLWFN (PubMed:9046589).CuratedAdd BLAST14
Sequence conflicti280P → PVESAP in AAC49114 (PubMed:7480350).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23155 mRNA. Translation: AAC49114.1.
U62029 Genomic DNA. Translation: AAB51193.1.
AF236873 mRNA. Translation: AAF80594.1.
AB005242 Genomic DNA. Translation: BAB09606.1.
CP002688 Genomic DNA. Translation: AED92286.1.
AY054617 mRNA. Translation: AAK96808.1.
AY072460 mRNA. Translation: AAL66875.1.
AY087857 mRNA. Translation: AAM65409.1.
RefSeqiNP_197143.1. NM_121644.4. [Q42533-1]
UniGeneiAt.22338.

Genome annotation databases

EnsemblPlantsiAT5G16390.1; AT5G16390.1; AT5G16390. [Q42533-1]
GeneIDi831500.
GrameneiAT5G16390.1; AT5G16390.1; AT5G16390.
KEGGiath:AT5G16390.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23155 mRNA. Translation: AAC49114.1.
U62029 Genomic DNA. Translation: AAB51193.1.
AF236873 mRNA. Translation: AAF80594.1.
AB005242 Genomic DNA. Translation: BAB09606.1.
CP002688 Genomic DNA. Translation: AED92286.1.
AY054617 mRNA. Translation: AAK96808.1.
AY072460 mRNA. Translation: AAL66875.1.
AY087857 mRNA. Translation: AAM65409.1.
RefSeqiNP_197143.1. NM_121644.4. [Q42533-1]
UniGeneiAt.22338.

3D structure databases

ProteinModelPortaliQ42533.
SMRiQ42533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16776. 1 interactor.
DIPiDIP-58514N.
MINTiMINT-8062366.
STRINGi3702.AT5G16390.1.

Proteomic databases

PaxDbiQ42533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G16390.1; AT5G16390.1; AT5G16390. [Q42533-1]
GeneIDi831500.
GrameneiAT5G16390.1; AT5G16390.1; AT5G16390.
KEGGiath:AT5G16390.

Organism-specific databases

TAIRiAT5G16390.

Phylogenomic databases

eggNOGiENOG410IXUZ. Eukaryota.
COG0511. LUCA.
HOGENOMiHOG000008876.
InParanoidiQ42533.
KOiK02160.
OMAiTSSHFPI.
OrthoDBiEOG09360PRH.
PhylomeDBiQ42533.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciARA:AT5G16390-MONOMER.

Miscellaneous databases

PROiQ42533.

Gene expression databases

ExpressionAtlasiQ42533. baseline and differential.
GenevisibleiQ42533. AT.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCCP1_ARATH
AccessioniPrimary (citable) accession number: Q42533
Secondary accession number(s): O04845, Q9LL78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 2, 2001
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.