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Q42522

- GSA2_ARATH

UniProt

Q42522 - GSA2_ARATH

Protein

Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic

Gene

GSA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Transaminase converting glutamate 1-semialdehyde (GSA) to 5-aminolevulinate (ALA). Involved in the biosynthesis of tetrapyrroles By similarity.By similarity

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciARA:AT3G48730-MONOMER.
    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic (EC:5.4.3.8)
    Short name:
    GSA 2
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase 2
    Short name:
    GSA-AT 2
    Gene namesi
    Name:GSA2
    Synonyms:HEML2
    Ordered Locus Names:At3g48730
    ORF Names:T8P19.240
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G48730.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: TAIR
    2. chloroplast envelope Source: TAIR
    3. chloroplast stroma Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3636ChloroplastBy similarityAdd
    BLAST
    Chaini37 – 472436Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplasticPRO_0000001256Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei312 – 3121N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PaxDbiQ42522.
    PRIDEiQ42522.

    Expressioni

    Gene expression databases

    GenevestigatoriQ42522.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi9352. 1 interaction.
    MINTiMINT-8069640.
    STRINGi3702.AT3G48730.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ42522.
    SMRiQ42522. Positions 50-472.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    InParanoidiQ42522.
    KOiK01845.
    OMAiRAIKPYP.
    PhylomeDBiQ42522.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q42522-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATLTGSGI ALGFSCSAKF SKRASSSSNR RCIKMSVSVE EKTKKFTLQK    50
    SEEAFNAAKN LMPGGVNSPV RAFKSVGGQP VVMDSAKGSR IRDIDGNEYI 100
    DYVGSWGPAI IGHADDEVLA ALAETMKKGT SFGAPCLLEN VLAEMVISAV 150
    PSIEMVRFVN SGTEACMGVL RLARAFTGKQ KFIKFEGCYH GHANSFLVKA 200
    GSGVATLGLP DSPGVPKAAT SDTLTAPYND IAAVEKLFEA NKGEIAAIIL 250
    EPVVGNSGFI TPKPEFIEGI RRITKDNGAL LIFDEVMTGF RLAYGGAQEY 300
    FGITPDLTTL GKIIGGGLPV GAYGGRRDIM EMVAPAGPMY QAGTLSGNPL 350
    AMTAGIHTLK RLSQPGTYEY LDKITKELTN GILEAGKKTG HAMCGGYISG 400
    MFGFFFTEGP VYDFSDAKKS DTEKFGKFFR GMLEEGVYLA PSQFEAGFTS 450
    LAHTSEDIQF TIAAAEKVLS RL 472
    Length:472
    Mass (Da):50,142
    Last modified:June 1, 2001 - v2
    Checksum:iE463699500B353FE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161C → S in AAA79123. 1 PublicationCurated
    Sequence conflicti194 – 1941N → K in AAA79123. 1 PublicationCurated
    Sequence conflicti283 – 2831F → L in AAA79123. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10278 Genomic DNA. Translation: AAA79123.1.
    AL133315 Genomic DNA. Translation: CAB62362.1.
    CP002686 Genomic DNA. Translation: AEE78450.1.
    BT025324 mRNA. Translation: ABF57280.1.
    AK229328 mRNA. Translation: BAF01191.1.
    PIRiT46217.
    RefSeqiNP_190442.1. NM_114732.4.
    UniGeneiAt.19963.

    Genome annotation databases

    EnsemblPlantsiAT3G48730.1; AT3G48730.1; AT3G48730.
    GeneIDi824034.
    KEGGiath:AT3G48730.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10278 Genomic DNA. Translation: AAA79123.1 .
    AL133315 Genomic DNA. Translation: CAB62362.1 .
    CP002686 Genomic DNA. Translation: AEE78450.1 .
    BT025324 mRNA. Translation: ABF57280.1 .
    AK229328 mRNA. Translation: BAF01191.1 .
    PIRi T46217.
    RefSeqi NP_190442.1. NM_114732.4.
    UniGenei At.19963.

    3D structure databases

    ProteinModelPortali Q42522.
    SMRi Q42522. Positions 50-472.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 9352. 1 interaction.
    MINTi MINT-8069640.
    STRINGi 3702.AT3G48730.1-P.

    Proteomic databases

    PaxDbi Q42522.
    PRIDEi Q42522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G48730.1 ; AT3G48730.1 ; AT3G48730 .
    GeneIDi 824034.
    KEGGi ath:AT3G48730.

    Organism-specific databases

    TAIRi AT3G48730.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    InParanoidi Q42522.
    KOi K01845.
    OMAi RAIKPYP.
    PhylomeDBi Q42522.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .
    BioCyci ARA:AT3G48730-MONOMER.

    Gene expression databases

    Genevestigatori Q42522.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a gene encoding glutamate 1-semialdehyde aminotransferase from Arabidopsis thaliana 'Columbia'."
      Wenzlau J.M., Berry-Lowe S.L.
      Plant Gene Register PGR95-007
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clones."
      Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiGSA2_ARATH
    AccessioniPrimary (citable) accession number: Q42522
    Secondary accession number(s): Q1JPM9, Q9SMM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3