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UniProtKB - Q42480 (TBB1_CHOCR)

UniProt

Q42480 - TBB1_CHOCR

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Protein

Tubulin beta-1 chain

Gene

TUBB

Organism
Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1487GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta-1 chain
Alternative name(s):
Beta-1-tubulin
Gene namesi
Name:TUBB
Synonyms:TUB1
OrganismiChondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Taxonomic identifieri2769 [NCBI]
Taxonomic lineageiEukaryota › Rhodophyta › Florideophyceae › Gigartinales › Gigartinaceae › Chondrus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Tubulin beta-1 chainPRO_0000048333Add
BLAST

Proteomic databases

PRIDEiQ42480.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Structurei

3D structure databases

ProteinModelPortaliQ42480.
SMRiQ42480. Positions 3-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

KOiK07375.
PhylomeDBiQ42480.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSIVSLQV GQCGNQVGLK FWEGISAEHG IDVDGKYIGD RPDQELHRIG 
        60         70         80         90        100
VYYNESSSGS YVPRAAMLDL EPGVLMAIKN SKRGQLFHPD NFAYGQSGAG 
       110        120        130        140        150
NNWAKGHYTE GAELVETALD IIRREAETCD VLQGFQVTHS LGGGTGSGMG 
       160        170        180        190        200
TLLVSKIREE YPDRMMCTYS VLPSPKVSDT VVEPYNCTLS IHQLIENADC 
       210        220        230        240        250
VFAIDNEALY NICYNTLKIE QPSYDELNSL ISSVMSGITC SLRFPGQLNA 
       260        270        280        290        300
DLRKLAVNLV PFPRLHFFAV GHAPLAASNS AGYRSLSVPE LAGQMFDRNN 
       310        320        330        340        350
MMAEIDPREG RYLTAAVYFR GKVSTKEVED EMTLMQTKNS AYFVEWIPHN 
       360        370        380        390        400
IKTSVCDIPA AGEKISSAFI GNTTAIEATF KRFGNQFRSM FRRKAFLHWY 
       410        420        430        440        450
KSEGMDELEF SEAESNLADL VSEYQQYGEA TADGVEGYEE EGYENDHPED 

DEE
Length:453
Mass (Da):50,346
Last modified:November 1, 1996 - v1
Checksum:i52C51FB7B1510B1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71785 Genomic DNA. Translation: CAA50670.1.
X71784 mRNA. Translation: CAA50669.1.
PIRiS55935. S49168.
RefSeqiXP_005715672.1. XM_005715615.1.

Genome annotation databases

GeneIDi17323383.
KEGGiccp:CHC_T00004301001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71785 Genomic DNA. Translation: CAA50670.1.
X71784 mRNA. Translation: CAA50669.1.
PIRiS55935. S49168.
RefSeqiXP_005715672.1. XM_005715615.1.

3D structure databases

ProteinModelPortaliQ42480.
SMRiQ42480. Positions 3-427.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ42480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17323383.
KEGGiccp:CHC_T00004301001.

Phylogenomic databases

KOiK07375.
PhylomeDBiQ42480.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBB1_CHOCR
AccessioniPrimary (citable) accession number: Q42480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.