UniProtKB - Q42480 (TBB1_CHOCR)
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Protein
Tubulin beta-1 chain
Gene
TUBB
Organism
Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Status
Functioni
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 142 – 148 | GTPSequence analysis | 7 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: UniProtKB-KW
- structural constituent of cytoskeleton Source: InterPro
GO - Biological processi
- microtubule-based process Source: InterPro
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin beta-1 chainAlternative name(s): Beta-1-tubulin |
Gene namesi | Name:TUBB Synonyms:TUB1 |
Organismi | Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa) |
Taxonomic identifieri | 2769 [NCBI] |
Taxonomic lineagei | Eukaryota › Rhodophyta › Florideophyceae › Rhodymeniophycidae › Gigartinales › Gigartinaceae › Chondrus |
Subcellular locationi
GO - Cellular componenti
- cytoplasm Source: UniProtKB-KW
- microtubule Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048333 | 1 – 453 | Tubulin beta-1 chainAdd BLAST | 453 |
Proteomic databases
PRIDEi | Q42480. |
Interactioni
Subunit structurei
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Structurei
3D structure databases
ProteinModelPortali | Q42480. |
SMRi | Q42480. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the tubulin family.Curated
Phylogenomic databases
KOi | K07375. |
OMAi | EVEACEC. |
PhylomeDBi | Q42480. |
Family and domain databases
Gene3Di | 1.10.287.600. 1 hit. 3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit. |
InterProi | View protein in InterPro IPR002453. Beta_tubulin. IPR008280. Tub_FtsZ_C. IPR000217. Tubulin. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR023123. Tubulin_C. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase. |
PANTHERi | PTHR11588. PTHR11588. 1 hit. PTHR11588:SF256. PTHR11588:SF256. 1 hit. |
Pfami | View protein in Pfam PF00091. Tubulin. 1 hit. PF03953. Tubulin_C. 1 hit. |
PRINTSi | PR01163. BETATUBULIN. PR01161. TUBULIN. |
SMARTi | View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit. |
SUPFAMi | SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit. |
PROSITEi | View protein in PROSITE PS00227. TUBULIN. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q42480-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRSIVSLQV GQCGNQVGLK FWEGISAEHG IDVDGKYIGD RPDQELHRIG
60 70 80 90 100
VYYNESSSGS YVPRAAMLDL EPGVLMAIKN SKRGQLFHPD NFAYGQSGAG
110 120 130 140 150
NNWAKGHYTE GAELVETALD IIRREAETCD VLQGFQVTHS LGGGTGSGMG
160 170 180 190 200
TLLVSKIREE YPDRMMCTYS VLPSPKVSDT VVEPYNCTLS IHQLIENADC
210 220 230 240 250
VFAIDNEALY NICYNTLKIE QPSYDELNSL ISSVMSGITC SLRFPGQLNA
260 270 280 290 300
DLRKLAVNLV PFPRLHFFAV GHAPLAASNS AGYRSLSVPE LAGQMFDRNN
310 320 330 340 350
MMAEIDPREG RYLTAAVYFR GKVSTKEVED EMTLMQTKNS AYFVEWIPHN
360 370 380 390 400
IKTSVCDIPA AGEKISSAFI GNTTAIEATF KRFGNQFRSM FRRKAFLHWY
410 420 430 440 450
KSEGMDELEF SEAESNLADL VSEYQQYGEA TADGVEGYEE EGYENDHPED
DEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71785 Genomic DNA. Translation: CAA50670.1. X71784 mRNA. Translation: CAA50669.1. |
PIRi | S55935. S49168. |
RefSeqi | XP_005715672.1. XM_005715615.1. |
Genome annotation databases
EnsemblPlantsi | CDF35853; CDF35853; CHC_T00004301001. |
GeneIDi | 17323383. |
Gramenei | CDF35853; CDF35853; CHC_T00004301001. |
KEGGi | ccp:CHC_T00004301001. |
Similar proteinsi
Entry informationi
Entry namei | TBB1_CHOCR | |
Accessioni | Q42480Primary (citable) accession number: Q42480 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 28, 2018 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |