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Protein

Tubulin beta-1 chain

Gene

TUBB

Organism
Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta-1 chain
Alternative name(s):
Beta-1-tubulin
Gene namesi
Name:TUBB
Synonyms:TUB1
OrganismiChondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Taxonomic identifieri2769 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaFlorideophyceaeGigartinalesGigartinaceaeChondrus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000483331 – 453Tubulin beta-1 chainAdd BLAST453

Proteomic databases

PRIDEiQ42480.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Structurei

3D structure databases

ProteinModelPortaliQ42480.
SMRiQ42480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

KOiK07375.
OMAiEVEACEC.
PhylomeDBiQ42480.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q42480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSIVSLQV GQCGNQVGLK FWEGISAEHG IDVDGKYIGD RPDQELHRIG
60 70 80 90 100
VYYNESSSGS YVPRAAMLDL EPGVLMAIKN SKRGQLFHPD NFAYGQSGAG
110 120 130 140 150
NNWAKGHYTE GAELVETALD IIRREAETCD VLQGFQVTHS LGGGTGSGMG
160 170 180 190 200
TLLVSKIREE YPDRMMCTYS VLPSPKVSDT VVEPYNCTLS IHQLIENADC
210 220 230 240 250
VFAIDNEALY NICYNTLKIE QPSYDELNSL ISSVMSGITC SLRFPGQLNA
260 270 280 290 300
DLRKLAVNLV PFPRLHFFAV GHAPLAASNS AGYRSLSVPE LAGQMFDRNN
310 320 330 340 350
MMAEIDPREG RYLTAAVYFR GKVSTKEVED EMTLMQTKNS AYFVEWIPHN
360 370 380 390 400
IKTSVCDIPA AGEKISSAFI GNTTAIEATF KRFGNQFRSM FRRKAFLHWY
410 420 430 440 450
KSEGMDELEF SEAESNLADL VSEYQQYGEA TADGVEGYEE EGYENDHPED

DEE
Length:453
Mass (Da):50,346
Last modified:November 1, 1996 - v1
Checksum:i52C51FB7B1510B1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71785 Genomic DNA. Translation: CAA50670.1.
X71784 mRNA. Translation: CAA50669.1.
PIRiS55935. S49168.
RefSeqiXP_005715672.1. XM_005715615.1.

Genome annotation databases

EnsemblPlantsiCDF35853; CDF35853; CHC_T00004301001.
GeneIDi17323383.
GrameneiCDF35853; CDF35853; CHC_T00004301001.
KEGGiccp:CHC_T00004301001.

Similar proteinsi

Entry informationi

Entry nameiTBB1_CHOCR
AccessioniPrimary (citable) accession number: Q42480
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families