TUBB

Functionⁱ

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	142 – 148	GTPSequence analysis		7

GO - Molecular functionⁱ

GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW
structural constituent of cytoskeleton Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

microtubule-based process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tubulin beta-1 chain Alternative name(s): Beta-1-tubulin
Gene namesⁱ	Name:TUBB Synonyms:TUB1
Organismⁱ	Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Taxonomic identifierⁱ	2769 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Rhodophyta › Florideophyceae › Rhodymeniophycidae › Gigartinales › Gigartinaceae › Chondrus

Subcellular locationⁱ

cytoskeleton

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-KW
microtubule Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048333	1 – 453	Tubulin beta-1 chainAdd BLAST		453

Proteomic databases

PRIDEⁱ	Q42480.

PRIDEⁱ

Q42480.

Interactionⁱ

Subunit structureⁱ

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q42480.
SMRⁱ	Q42480.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tubulin family.Curated

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K07375.
OMAⁱ	EVEACEC.
PhylomeDBⁱ	Q42480.

Family and domain databases

Gene3Dⁱ	1.10.287.600. 1 hit. 3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
InterProⁱ	View protein in InterPro IPR002453. Beta_tubulin. IPR008280. Tub_FtsZ_C. IPR000217. Tubulin. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR023123. Tubulin_C. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase.
PANTHERⁱ	PTHR11588. PTHR11588. 1 hit. PTHR11588:SF256. PTHR11588:SF256. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00091. Tubulin. 1 hit. PF03953. Tubulin_C. 1 hit.
PRINTSⁱ	PR01163. BETATUBULIN. PR01161. TUBULIN.
SMARTⁱ	View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit.
SUPFAMⁱ	SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00227. TUBULIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q42480-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTRSIVSLQV GQCGNQVGLK FWEGISAEHG IDVDGKYIGD RPDQELHRIG 
        60         70         80         90        100
VYYNESSSGS YVPRAAMLDL EPGVLMAIKN SKRGQLFHPD NFAYGQSGAG 
       110        120        130        140        150
NNWAKGHYTE GAELVETALD IIRREAETCD VLQGFQVTHS LGGGTGSGMG 
       160        170        180        190        200
TLLVSKIREE YPDRMMCTYS VLPSPKVSDT VVEPYNCTLS IHQLIENADC 
       210        220        230        240        250
VFAIDNEALY NICYNTLKIE QPSYDELNSL ISSVMSGITC SLRFPGQLNA 
       260        270        280        290        300
DLRKLAVNLV PFPRLHFFAV GHAPLAASNS AGYRSLSVPE LAGQMFDRNN 
       310        320        330        340        350
MMAEIDPREG RYLTAAVYFR GKVSTKEVED EMTLMQTKNS AYFVEWIPHN 
       360        370        380        390        400
IKTSVCDIPA AGEKISSAFI GNTTAIEATF KRFGNQFRSM FRRKAFLHWY 
       410        420        430        440        450
KSEGMDELEF SEAESNLADL VSEYQQYGEA TADGVEGYEE EGYENDHPED 

DEE

Length:453

Mass (Da):50,346

Last modified:November 1, 1996 - v1

Checksum:ⁱ52C51FB7B1510B1A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X71785 Genomic DNA. Translation: CAA50670.1. X71784 mRNA. Translation: CAA50669.1.
PIRⁱ	S55935. S49168.
NCBI Reference Sequences More...RefSeqⁱ	XP_005715672.1. XM_005715615.1.

Genome annotation databases

EnsemblPlantsⁱ	CDF35853; CDF35853; CHC_T00004301001.
GeneIDⁱ	17323383.
Grameneⁱ	CDF35853; CDF35853; CHC_T00004301001.
KEGGⁱ	ccp:CHC_T00004301001.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q42480	R7QDJ0	Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)	453	UniRef100_Q42480	Cluster: Tubulin beta-1 chain	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q42480	R7QDJ0	Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)	453	UniRef90_Q42480	Cluster: Tubulin beta-1 chain	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q42480	P04350 Q3ZBU7 Q4R4X8 Q9D6F9 G2HGK8 E2RFV2 A0A1D5QPK0 H0XHY1 G1PSQ1 A0A2J8R6F3 +2707	Homo sapiens (Human) Bos taurus (Bovine) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Mus musculus (Mouse) Pan troglodytes (Chimpanzee) Canis lupus familiaris (Dog) (Canis familiaris) Macaca mulatta (Rhesus macaque) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) Myotis lucifugus (Little brown bat) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) And more	444	UniRef50_P04350	Cluster: Tubulin beta-4A chain	2,718

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X71785 Genomic DNA. Translation: CAA50670.1. X71784 mRNA. Translation: CAA50669.1.
PIRⁱ	S55935. S49168.
NCBI Reference Sequences More...RefSeqⁱ	XP_005715672.1. XM_005715615.1.

3D structure databases

ProteinModelPortalⁱ	Q42480.
SMRⁱ	Q42480.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q42480.

PRIDEⁱ

Q42480.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	CDF35853; CDF35853; CHC_T00004301001.
GeneIDⁱ	17323383.
Grameneⁱ	CDF35853; CDF35853; CHC_T00004301001.
KEGGⁱ	ccp:CHC_T00004301001.

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K07375.
OMAⁱ	EVEACEC.
PhylomeDBⁱ	Q42480.

Family and domain databases

Gene3Dⁱ	1.10.287.600. 1 hit. 3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
InterProⁱ	View protein in InterPro IPR002453. Beta_tubulin. IPR008280. Tub_FtsZ_C. IPR000217. Tubulin. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR037103. Tubulin/FtsZ_C_sf. IPR036525. Tubulin/FtsZ_GTPase_sf. IPR023123. Tubulin_C. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase.
PANTHERⁱ	PTHR11588. PTHR11588. 1 hit. PTHR11588:SF256. PTHR11588:SF256. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00091. Tubulin. 1 hit. PF03953. Tubulin_C. 1 hit.
PRINTSⁱ	PR01163. BETATUBULIN. PR01161. TUBULIN.
SMARTⁱ	View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit.
SUPFAMⁱ	SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00227. TUBULIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TBB1_CHOCR
Accessionⁱ	Q42480Primary (citable) accession number: Q42480
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	February 28, 2018
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)

UniProtKB - Q42480 (TBB1_CHOCR)

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Tubulin beta-1 chain

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Functionⁱ

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Proteomic databases

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q42480 (TBB1_CHOCR)

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Tubulin beta-1 chain

TUBB

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ