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Protein

Profilin-1

Gene

PRO1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Biological processi

  1. actin polymerization or depolymerization Source: TAIR
  2. unidimensional cell growth Source: TAIR
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-1
Alternative name(s):
Allergen: Ara t 8
Gene namesi
Name:PRO1
Synonyms:PFN1, PRF1
Ordered Locus Names:At2g19760
ORF Names:F6F22.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G19760.

Subcellular locationi

  1. Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. cell wall Source: TAIR
  3. cytoplasm Source: TAIR
  4. cytosol Source: TAIR
  5. nucleolus Source: TAIR
  6. nucleus Source: TAIR
  7. phragmoplast Source: TAIR
  8. plasma membrane Source: TAIR
  9. plasmodesma Source: TAIR
  10. spindle Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Profilin-1PRO_0000199615Add
BLAST

Proteomic databases

PaxDbiQ42449.
PRIDEiQ42449.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevestigatoriQ42449.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Protein-protein interaction databases

BioGridi1850. 1 interaction.
IntActiQ42449. 1 interaction.
STRINGi3702.AT2G19760.1-P.

Structurei

Secondary structure

1
131
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97Combined sources
Beta strandi21 – 277Combined sources
Beta strandi32 – 354Combined sources
Helixi44 – 5512Combined sources
Turni61 – 633Combined sources
Beta strandi65 – 673Combined sources
Beta strandi70 – 789Combined sources
Turni79 – 813Combined sources
Beta strandi82 – 876Combined sources
Beta strandi90 – 967Combined sources
Beta strandi98 – 1069Combined sources
Helixi112 – 12817Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A0KX-ray2.20A1-131[»]
1PLMmodel-A2-131[»]
3NULX-ray1.60A2-131[»]
ProteinModelPortaliQ42449.
SMRiQ42449. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ42449.

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiNOG277929.
HOGENOMiHOG000171591.
InParanoidiQ42449.
KOiK05759.
OMAiMVIQGEQ.
PhylomeDBiQ42449.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQSYVDDH LMCDVEGNHL TAAAILGQDG SVWAQSAKFP QLKPQEIDGI
60 70 80 90 100
KKDFEEPGFL APTGLFLGGE KYMVIQGEQG AVIRGKKGPG GVTIKKTNQA
110 120 130
LVFGFYDEPM TGGQCNLVVE RLGDYLIESE L
Length:131
Mass (Da):14,266
Last modified:November 1, 1997 - v1
Checksum:i84212D4681F83F51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43325 mRNA. Translation: AAB39480.1.
U43322 Genomic DNA. Translation: AAB39476.1.
U43593 Genomic DNA. Translation: AAG10090.1.
U43590 mRNA. Translation: AAB46750.1.
AC005169 Genomic DNA. Translation: AAC62140.1.
CP002685 Genomic DNA. Translation: AEC06923.1.
AY072427 mRNA. Translation: AAL62419.1.
BT000264 mRNA. Translation: AAN15583.1.
PIRiG84580.
RefSeqiNP_179566.1. NM_127534.2.
UniGeneiAt.23712.

Genome annotation databases

EnsemblPlantsiAT2G19760.1; AT2G19760.1; AT2G19760.
GeneIDi816495.
KEGGiath:AT2G19760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43325 mRNA. Translation: AAB39480.1.
U43322 Genomic DNA. Translation: AAB39476.1.
U43593 Genomic DNA. Translation: AAG10090.1.
U43590 mRNA. Translation: AAB46750.1.
AC005169 Genomic DNA. Translation: AAC62140.1.
CP002685 Genomic DNA. Translation: AEC06923.1.
AY072427 mRNA. Translation: AAL62419.1.
BT000264 mRNA. Translation: AAN15583.1.
PIRiG84580.
RefSeqiNP_179566.1. NM_127534.2.
UniGeneiAt.23712.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A0KX-ray2.20A1-131[»]
1PLMmodel-A2-131[»]
3NULX-ray1.60A2-131[»]
ProteinModelPortaliQ42449.
SMRiQ42449. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1850. 1 interaction.
IntActiQ42449. 1 interaction.
STRINGi3702.AT2G19760.1-P.

Proteomic databases

PaxDbiQ42449.
PRIDEiQ42449.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G19760.1; AT2G19760.1; AT2G19760.
GeneIDi816495.
KEGGiath:AT2G19760.

Organism-specific databases

TAIRiAT2G19760.

Phylogenomic databases

eggNOGiNOG277929.
HOGENOMiHOG000171591.
InParanoidiQ42449.
KOiK05759.
OMAiMVIQGEQ.
PhylomeDBiQ42449.

Miscellaneous databases

EvolutionaryTraceiQ42449.
PROiQ42449.

Gene expression databases

GenevestigatoriQ42449.

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Arabidopsis profilins are functionally similar to yeast profilins: identification of a vascular bundle-specific profilin and a pollen-specific profilin."
    Christensen H.E.M., Ramachandran S., Tan C.T., Surana U., Dong C.H., Chua N.-H.
    Plant J. 10:269-279(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Columbia.
  2. "The Arabidopsis profilin gene family. Evidence for an ancient split between constitutive and pollen-specific profilin genes."
    Huang S., McDowell J.M., Weise M.J., Meagher R.B.
    Plant Physiol. 111:115-126(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiPROF1_ARATH
AccessioniPrimary (citable) accession number: Q42449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 29, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.