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Q42449

- PROF1_ARATH

UniProt

Q42449 - PROF1_ARATH

Protein

Profilin-1

Gene

PRO1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.By similarity

    GO - Biological processi

    1. actin polymerization or depolymerization Source: TAIR
    2. unidimensional cell growth Source: TAIR

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin-1
    Alternative name(s):
    Allergen: Ara t 8
    Gene namesi
    Name:PRO1
    Synonyms:PFN1, PRF1
    Ordered Locus Names:At2g19760
    ORF Names:F6F22.21
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G19760.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. apoplast Source: TAIR
    2. cell wall Source: TAIR
    3. cytoplasm Source: TAIR
    4. cytosol Source: TAIR
    5. nucleolus Source: TAIR
    6. nucleus Source: TAIR
    7. phragmoplast Source: TAIR
    8. plasma membrane Source: TAIR
    9. plasmodesma Source: TAIR
    10. spindle Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 131131Profilin-1PRO_0000199615Add
    BLAST

    Proteomic databases

    PaxDbiQ42449.
    PRIDEiQ42449.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    GenevestigatoriQ42449.

    Interactioni

    Subunit structurei

    Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

    Protein-protein interaction databases

    BioGridi1850. 1 interaction.
    IntActiQ42449. 1 interaction.
    STRINGi3702.AT2G19760.1-P.

    Structurei

    Secondary structure

    1
    131
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 97
    Beta strandi21 – 277
    Beta strandi32 – 354
    Helixi44 – 5512
    Turni61 – 633
    Beta strandi65 – 673
    Beta strandi70 – 789
    Turni79 – 813
    Beta strandi82 – 876
    Beta strandi90 – 967
    Beta strandi98 – 1069
    Helixi112 – 12817

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A0KX-ray2.20A1-131[»]
    1PLMmodel-A2-131[»]
    3NULX-ray1.60A2-131[»]
    ProteinModelPortaliQ42449.
    SMRiQ42449. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ42449.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Phylogenomic databases

    eggNOGiNOG277929.
    HOGENOMiHOG000171591.
    InParanoidiQ42449.
    KOiK05759.
    OMAiKKDFEEP.
    PhylomeDBiQ42449.

    Family and domain databases

    InterProiIPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PANTHERiPTHR11604. PTHR11604. 1 hit.
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTiSM00392. PROF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55770. SSF55770. 1 hit.
    PROSITEiPS00414. PROFILIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q42449-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWQSYVDDH LMCDVEGNHL TAAAILGQDG SVWAQSAKFP QLKPQEIDGI    50
    KKDFEEPGFL APTGLFLGGE KYMVIQGEQG AVIRGKKGPG GVTIKKTNQA 100
    LVFGFYDEPM TGGQCNLVVE RLGDYLIESE L 131
    Length:131
    Mass (Da):14,266
    Last modified:November 1, 1997 - v1
    Checksum:i84212D4681F83F51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43325 mRNA. Translation: AAB39480.1.
    U43322 Genomic DNA. Translation: AAB39476.1.
    U43593 Genomic DNA. Translation: AAG10090.1.
    U43590 mRNA. Translation: AAB46750.1.
    AC005169 Genomic DNA. Translation: AAC62140.1.
    CP002685 Genomic DNA. Translation: AEC06923.1.
    AY072427 mRNA. Translation: AAL62419.1.
    BT000264 mRNA. Translation: AAN15583.1.
    PIRiG84580.
    RefSeqiNP_179566.1. NM_127534.2.
    UniGeneiAt.23712.

    Genome annotation databases

    EnsemblPlantsiAT2G19760.1; AT2G19760.1; AT2G19760.
    GeneIDi816495.
    KEGGiath:AT2G19760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43325 mRNA. Translation: AAB39480.1 .
    U43322 Genomic DNA. Translation: AAB39476.1 .
    U43593 Genomic DNA. Translation: AAG10090.1 .
    U43590 mRNA. Translation: AAB46750.1 .
    AC005169 Genomic DNA. Translation: AAC62140.1 .
    CP002685 Genomic DNA. Translation: AEC06923.1 .
    AY072427 mRNA. Translation: AAL62419.1 .
    BT000264 mRNA. Translation: AAN15583.1 .
    PIRi G84580.
    RefSeqi NP_179566.1. NM_127534.2.
    UniGenei At.23712.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A0K X-ray 2.20 A 1-131 [» ]
    1PLM model - A 2-131 [» ]
    3NUL X-ray 1.60 A 2-131 [» ]
    ProteinModelPortali Q42449.
    SMRi Q42449. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1850. 1 interaction.
    IntActi Q42449. 1 interaction.
    STRINGi 3702.AT2G19760.1-P.

    Proteomic databases

    PaxDbi Q42449.
    PRIDEi Q42449.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G19760.1 ; AT2G19760.1 ; AT2G19760 .
    GeneIDi 816495.
    KEGGi ath:AT2G19760.

    Organism-specific databases

    TAIRi AT2G19760.

    Phylogenomic databases

    eggNOGi NOG277929.
    HOGENOMi HOG000171591.
    InParanoidi Q42449.
    KOi K05759.
    OMAi KKDFEEP.
    PhylomeDBi Q42449.

    Miscellaneous databases

    EvolutionaryTracei Q42449.

    Gene expression databases

    Genevestigatori Q42449.

    Family and domain databases

    InterProi IPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    PANTHERi PTHR11604. PTHR11604. 1 hit.
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTi SM00392. PROF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55770. SSF55770. 1 hit.
    PROSITEi PS00414. PROFILIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Arabidopsis profilins are functionally similar to yeast profilins: identification of a vascular bundle-specific profilin and a pollen-specific profilin."
      Christensen H.E.M., Ramachandran S., Tan C.T., Surana U., Dong C.H., Chua N.-H.
      Plant J. 10:269-279(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: cv. Columbia.
    2. "The Arabidopsis profilin gene family. Evidence for an ancient split between constitutive and pollen-specific profilin genes."
      Huang S., McDowell J.M., Weise M.J., Meagher R.B.
      Plant Physiol. 111:115-126(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

    Entry informationi

    Entry nameiPROF1_ARATH
    AccessioniPrimary (citable) accession number: Q42449
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3