SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q42449

- PROF1_ARATH

UniProt

Q42449 - PROF1_ARATH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Profilin-1

Gene
PRO1, PFN1, PRF1, At2g19760, F6F22.21
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.

GO - Biological processi

  1. actin polymerization or depolymerization Source: TAIR
  2. unidimensional cell growth Source: TAIR
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-1
Alternative name(s):
Allergen: Ara t 8
Gene namesi
Name:PRO1
Synonyms:PFN1, PRF1
Ordered Locus Names:At2g19760
ORF Names:F6F22.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G19760.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. apoplast Source: TAIR
  2. cell wall Source: TAIR
  3. cytoplasm Source: TAIR
  4. cytosol Source: TAIR
  5. nucleolus Source: TAIR
  6. nucleus Source: TAIR
  7. phragmoplast Source: TAIR
  8. plasma membrane Source: TAIR
  9. plasmodesma Source: TAIR
  10. spindle Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Profilin-1PRO_0000199615Add
BLAST

Proteomic databases

PaxDbiQ42449.
PRIDEiQ42449.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevestigatoriQ42449.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Protein-protein interaction databases

BioGridi1850. 1 interaction.
IntActiQ42449. 1 interaction.
STRINGi3702.AT2G19760.1-P.

Structurei

Secondary structure

1
131
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 97
Beta strandi21 – 277
Beta strandi32 – 354
Helixi44 – 5512
Turni61 – 633
Beta strandi65 – 673
Beta strandi70 – 789
Turni79 – 813
Beta strandi82 – 876
Beta strandi90 – 967
Beta strandi98 – 1069
Helixi112 – 12817

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A0KX-ray2.20A1-131[»]
1PLMmodel-A2-131[»]
3NULX-ray1.60A2-131[»]
ProteinModelPortaliQ42449.
SMRiQ42449. Positions 2-131.

Miscellaneous databases

EvolutionaryTraceiQ42449.

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.

Phylogenomic databases

eggNOGiNOG277929.
HOGENOMiHOG000171591.
InParanoidiQ42449.
KOiK05759.
OMAiKKDFEEP.
PhylomeDBiQ42449.

Family and domain databases

InterProiIPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42449-1 [UniParc]FASTAAdd to Basket

« Hide

MSWQSYVDDH LMCDVEGNHL TAAAILGQDG SVWAQSAKFP QLKPQEIDGI    50
KKDFEEPGFL APTGLFLGGE KYMVIQGEQG AVIRGKKGPG GVTIKKTNQA 100
LVFGFYDEPM TGGQCNLVVE RLGDYLIESE L 131
Length:131
Mass (Da):14,266
Last modified:November 1, 1997 - v1
Checksum:i84212D4681F83F51
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43325 mRNA. Translation: AAB39480.1.
U43322 Genomic DNA. Translation: AAB39476.1.
U43593 Genomic DNA. Translation: AAG10090.1.
U43590 mRNA. Translation: AAB46750.1.
AC005169 Genomic DNA. Translation: AAC62140.1.
CP002685 Genomic DNA. Translation: AEC06923.1.
AY072427 mRNA. Translation: AAL62419.1.
BT000264 mRNA. Translation: AAN15583.1.
PIRiG84580.
RefSeqiNP_179566.1. NM_127534.2.
UniGeneiAt.23712.

Genome annotation databases

EnsemblPlantsiAT2G19760.1; AT2G19760.1; AT2G19760.
GeneIDi816495.
KEGGiath:AT2G19760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43325 mRNA. Translation: AAB39480.1 .
U43322 Genomic DNA. Translation: AAB39476.1 .
U43593 Genomic DNA. Translation: AAG10090.1 .
U43590 mRNA. Translation: AAB46750.1 .
AC005169 Genomic DNA. Translation: AAC62140.1 .
CP002685 Genomic DNA. Translation: AEC06923.1 .
AY072427 mRNA. Translation: AAL62419.1 .
BT000264 mRNA. Translation: AAN15583.1 .
PIRi G84580.
RefSeqi NP_179566.1. NM_127534.2.
UniGenei At.23712.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A0K X-ray 2.20 A 1-131 [» ]
1PLM model - A 2-131 [» ]
3NUL X-ray 1.60 A 2-131 [» ]
ProteinModelPortali Q42449.
SMRi Q42449. Positions 2-131.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1850. 1 interaction.
IntActi Q42449. 1 interaction.
STRINGi 3702.AT2G19760.1-P.

Proteomic databases

PaxDbi Q42449.
PRIDEi Q42449.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G19760.1 ; AT2G19760.1 ; AT2G19760 .
GeneIDi 816495.
KEGGi ath:AT2G19760.

Organism-specific databases

TAIRi AT2G19760.

Phylogenomic databases

eggNOGi NOG277929.
HOGENOMi HOG000171591.
InParanoidi Q42449.
KOi K05759.
OMAi KKDFEEP.
PhylomeDBi Q42449.

Miscellaneous databases

EvolutionaryTracei Q42449.

Gene expression databases

Genevestigatori Q42449.

Family and domain databases

InterProi IPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view ]
PANTHERi PTHR11604. PTHR11604. 1 hit.
Pfami PF00235. Profilin. 1 hit.
[Graphical view ]
PRINTSi PR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTi SM00392. PROF. 1 hit.
[Graphical view ]
SUPFAMi SSF55770. SSF55770. 1 hit.
PROSITEi PS00414. PROFILIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Arabidopsis profilins are functionally similar to yeast profilins: identification of a vascular bundle-specific profilin and a pollen-specific profilin."
    Christensen H.E.M., Ramachandran S., Tan C.T., Surana U., Dong C.H., Chua N.-H.
    Plant J. 10:269-279(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Columbia.
  2. "The Arabidopsis profilin gene family. Evidence for an ancient split between constitutive and pollen-specific profilin genes."
    Huang S., McDowell J.M., Weise M.J., Meagher R.B.
    Plant Physiol. 111:115-126(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiPROF1_ARATH
AccessioniPrimary (citable) accession number: Q42449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi