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Protein

Profilin-1

Gene

PRO1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • actin polymerization or depolymerization Source: TAIR
  • inflorescence development Source: TAIR
  • lateral root development Source: TAIR
  • leaf development Source: TAIR
  • sequestering of actin monomers Source: GO_Central
  • unidimensional cell growth Source: TAIR

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-1
Alternative name(s):
Allergen: Ara t 8
Gene namesi
Name:PRO1
Synonyms:PFN1, PRF1
Ordered Locus Names:At2g19760
ORF Names:F6F22.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G19760.
TAIRilocus:2051965. AT2G19760.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001996151 – 131Profilin-1Add BLAST131

Proteomic databases

PaxDbiQ42449.
PRIDEiQ42449.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ExpressionAtlasiQ42449. baseline and differential.
GenevisibleiQ42449. AT.

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1850. 1 interactor.
IntActiQ42449. 1 interactor.
STRINGi3702.AT2G19760.1.

Structurei

Secondary structure

1131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 9Combined sources7
Beta strandi21 – 27Combined sources7
Beta strandi32 – 35Combined sources4
Helixi44 – 55Combined sources12
Turni61 – 63Combined sources3
Beta strandi65 – 67Combined sources3
Beta strandi70 – 78Combined sources9
Turni79 – 81Combined sources3
Beta strandi82 – 87Combined sources6
Beta strandi90 – 96Combined sources7
Beta strandi98 – 106Combined sources9
Helixi112 – 128Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0KX-ray2.20A1-131[»]
1PLMmodel-A2-131[»]
3NULX-ray1.60A2-131[»]
ProteinModelPortaliQ42449.
SMRiQ42449.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ42449.

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755. Eukaryota.
ENOG41126PD. LUCA.
HOGENOMiHOG000171591.
InParanoidiQ42449.
KOiK05759.
OMAiMVIQGEQ.
OrthoDBiEOG09360WEB.
PhylomeDBiQ42449.

Family and domain databases

CDDicd00148. PROF. 1 hit.
InterProiView protein in InterPro
IPR005455. PFN.
IPR036140. PFN_sf.
IPR027310. Profilin_CS.
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiView protein in Pfam
PF00235. Profilin. 1 hit.
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiView protein in SMART
SM00392. PROF. 1 hit.
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiView protein in PROSITE
PS00414. PROFILIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q42449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWQSYVDDH LMCDVEGNHL TAAAILGQDG SVWAQSAKFP QLKPQEIDGI
60 70 80 90 100
KKDFEEPGFL APTGLFLGGE KYMVIQGEQG AVIRGKKGPG GVTIKKTNQA
110 120 130
LVFGFYDEPM TGGQCNLVVE RLGDYLIESE L
Length:131
Mass (Da):14,266
Last modified:November 1, 1997 - v1
Checksum:i84212D4681F83F51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43325 mRNA. Translation: AAB39480.1.
U43322 Genomic DNA. Translation: AAB39476.1.
U43593 Genomic DNA. Translation: AAG10090.1.
U43590 mRNA. Translation: AAB46750.1.
AC005169 Genomic DNA. Translation: AAC62140.1.
CP002685 Genomic DNA. Translation: AEC06923.1.
AY072427 mRNA. Translation: AAL62419.1.
BT000264 mRNA. Translation: AAN15583.1.
PIRiG84580.
RefSeqiNP_179566.1. NM_127534.3.
UniGeneiAt.23712.

Genome annotation databases

EnsemblPlantsiAT2G19760.1; AT2G19760.1; AT2G19760.
GeneIDi816495.
GrameneiAT2G19760.1; AT2G19760.1; AT2G19760.
KEGGiath:AT2G19760.

Similar proteinsi

Entry informationi

Entry nameiPROF1_ARATH
AccessioniPrimary (citable) accession number: Q42449
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 20, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families