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Q42434

- BIP_SPIOL

UniProt

Q42434 - BIP_SPIOL

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Protein

Luminal-binding protein

Gene

HSC70

Organism
Spinacia oleracea (Spinach)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Luminal-binding protein
Short name:
BiP
Alternative name(s):
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Gene namesi
Name:HSC70
OrganismiSpinacia oleracea (Spinach)
Taxonomic identifieri3562 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeChenopodioideaeAnserineaeSpinacia

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 668640Luminal-binding proteinPRO_0000013593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ42434.

Structurei

3D structure databases

ProteinModelPortaliQ42434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi665 – 6684Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42434-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVAWKSRAS SIAFGIVLLG SLFAFVSAKD EAPKLGTVIG IDLGTTYSCV
60 70 80 90 100
GVYKDGKVEI IANDQGNRIT PSWVAFTNDE RLIGEAAKNQ AAANPERTIF
110 120 130 140 150
DVKRLIGRKF EDKEVQKDMK LVPYKIVNRD GKPYIQVKVQ EGETKVFSPE
160 170 180 190 200
EISAMILTKM KETAETFLGK KIKDAVVTVP AYFNDAQRQA TKDAGVIAGL
210 220 230 240 250
NVARIINEPT AAAIAYGLDK RGGEKNILVF DLGGGTFDVS VLTIDNGVFE
260 270 280 290 300
VLATNGDTHL GGEDFDQRLM EYFIKLIKKK HTKDISKDNR ALGKLRRECE
310 320 330 340 350
RAKRALSSQH QVRVEIESLF DGVDFSEPLT RARFEELNND LFRKTMGPVK
360 370 380 390 400
KAMDDAGLEK NQIDEIVLVG GSTRIPKVQQ LLKEFFNGKE PSKGVNPDEA
410 420 430 440 450
VAFGAAVQGS ILSGEGGEET KEILLLDVAP LTLGIETVGG VMTKLIPRNT
460 470 480 490 500
VIPTKKSQVF TTYQDQQTTV TIQVFEGERS LTKDCRLLGK FDLTGIAPAP
510 520 530 540 550
RGTPQIEVTF EVDANGILNV KAEDKASGKS EKITITNDKG RLSQEEIERM
560 570 580 590 600
VREAEEFAEE DKKVKEKIDA RNSLETYIYN MKNQISDADK LADKLESDEK
610 620 630 640 650
EKIEGAVKEA LEWLDDNQSA EKEDYDEKLK EVEAVCNPII TAVYQRSGGP
660
SGESGADSED SEEGHDEL
Length:668
Mass (Da):73,592
Last modified:November 1, 1996 - v1
Checksum:i68043D93B56196A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23551 mRNA. Translation: AAA21808.1.
L23552 Genomic DNA. Translation: AAA21806.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23551 mRNA. Translation: AAA21808.1 .
L23552 Genomic DNA. Translation: AAA21806.1 .

3D structure databases

ProteinModelPortali Q42434.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q42434.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A cDNA encoding the endoplasmic reticulum-luminal heat-shock protein from spinach (Spinacia oleracea L.)."
    Anderson J.V., Neven L.G., Li Q.B., Haskell D.W., Guy C.L.
    Plant Physiol. 104:303-304(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Bloomsdale.
    Tissue: Leaf.
  2. "Structural organization of the spinach endoplasmic reticulum-luminal 70-kilodalton heat-shock cognate gene and expression of 70-kilodalton heat-shock genes during cold acclimation."
    Anderson J.V., Li Q.B., Haskell D.W., Guy C.L.
    Plant Physiol. 104:1359-1370(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Bloomsdale.
    Tissue: Leaf.

Entry informationi

Entry nameiBIP_SPIOL
AccessioniPrimary (citable) accession number: Q42434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3