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Q42434

- BIP_SPIOL

UniProt

Q42434 - BIP_SPIOL

Protein

Luminal-binding protein

Gene

HSC70

Organism
Spinacia oleracea (Spinach)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Luminal-binding protein
    Short name:
    BiP
    Alternative name(s):
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    Gene namesi
    Name:HSC70
    OrganismiSpinacia oleracea (Spinach)
    Taxonomic identifieri3562 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeChenopodioideaeAnserineaeSpinacia

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 668640Luminal-binding proteinPRO_0000013593Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ42434.

    Structurei

    3D structure databases

    ProteinModelPortaliQ42434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi665 – 6684Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q42434-1 [UniParc]FASTAAdd to Basket

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    MAVAWKSRAS SIAFGIVLLG SLFAFVSAKD EAPKLGTVIG IDLGTTYSCV    50
    GVYKDGKVEI IANDQGNRIT PSWVAFTNDE RLIGEAAKNQ AAANPERTIF 100
    DVKRLIGRKF EDKEVQKDMK LVPYKIVNRD GKPYIQVKVQ EGETKVFSPE 150
    EISAMILTKM KETAETFLGK KIKDAVVTVP AYFNDAQRQA TKDAGVIAGL 200
    NVARIINEPT AAAIAYGLDK RGGEKNILVF DLGGGTFDVS VLTIDNGVFE 250
    VLATNGDTHL GGEDFDQRLM EYFIKLIKKK HTKDISKDNR ALGKLRRECE 300
    RAKRALSSQH QVRVEIESLF DGVDFSEPLT RARFEELNND LFRKTMGPVK 350
    KAMDDAGLEK NQIDEIVLVG GSTRIPKVQQ LLKEFFNGKE PSKGVNPDEA 400
    VAFGAAVQGS ILSGEGGEET KEILLLDVAP LTLGIETVGG VMTKLIPRNT 450
    VIPTKKSQVF TTYQDQQTTV TIQVFEGERS LTKDCRLLGK FDLTGIAPAP 500
    RGTPQIEVTF EVDANGILNV KAEDKASGKS EKITITNDKG RLSQEEIERM 550
    VREAEEFAEE DKKVKEKIDA RNSLETYIYN MKNQISDADK LADKLESDEK 600
    EKIEGAVKEA LEWLDDNQSA EKEDYDEKLK EVEAVCNPII TAVYQRSGGP 650
    SGESGADSED SEEGHDEL 668
    Length:668
    Mass (Da):73,592
    Last modified:November 1, 1996 - v1
    Checksum:i68043D93B56196A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23551 mRNA. Translation: AAA21808.1.
    L23552 Genomic DNA. Translation: AAA21806.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23551 mRNA. Translation: AAA21808.1 .
    L23552 Genomic DNA. Translation: AAA21806.1 .

    3D structure databases

    ProteinModelPortali Q42434.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q42434.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cDNA encoding the endoplasmic reticulum-luminal heat-shock protein from spinach (Spinacia oleracea L.)."
      Anderson J.V., Neven L.G., Li Q.B., Haskell D.W., Guy C.L.
      Plant Physiol. 104:303-304(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Bloomsdale.
      Tissue: Leaf.
    2. "Structural organization of the spinach endoplasmic reticulum-luminal 70-kilodalton heat-shock cognate gene and expression of 70-kilodalton heat-shock genes during cold acclimation."
      Anderson J.V., Li Q.B., Haskell D.W., Guy C.L.
      Plant Physiol. 104:1359-1370(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Bloomsdale.
      Tissue: Leaf.

    Entry informationi

    Entry nameiBIP_SPIOL
    AccessioniPrimary (citable) accession number: Q42434
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3