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Q42434 (BIP_SPIOL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Luminal-binding protein

Short name=BiP
Alternative name(s):
78 kDa glucose-regulated protein homolog
Short name=GRP-78
Gene names
Name:HSC70
OrganismSpinacia oleracea (Spinach)
Taxonomic identifier3562 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeChenopodioideaeAnserineaeSpinacia

Protein attributes

Sequence length668 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular location

Endoplasmic reticulum lumen.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 668640Luminal-binding protein
PRO_0000013593

Regions

Motif665 – 6684Prevents secretion from ER Potential

Amino acid modifications

Glycosylation6171N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q42434 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 68043D93B56196A8

FASTA66873,592
        10         20         30         40         50         60 
MAVAWKSRAS SIAFGIVLLG SLFAFVSAKD EAPKLGTVIG IDLGTTYSCV GVYKDGKVEI 

        70         80         90        100        110        120 
IANDQGNRIT PSWVAFTNDE RLIGEAAKNQ AAANPERTIF DVKRLIGRKF EDKEVQKDMK 

       130        140        150        160        170        180 
LVPYKIVNRD GKPYIQVKVQ EGETKVFSPE EISAMILTKM KETAETFLGK KIKDAVVTVP 

       190        200        210        220        230        240 
AYFNDAQRQA TKDAGVIAGL NVARIINEPT AAAIAYGLDK RGGEKNILVF DLGGGTFDVS 

       250        260        270        280        290        300 
VLTIDNGVFE VLATNGDTHL GGEDFDQRLM EYFIKLIKKK HTKDISKDNR ALGKLRRECE 

       310        320        330        340        350        360 
RAKRALSSQH QVRVEIESLF DGVDFSEPLT RARFEELNND LFRKTMGPVK KAMDDAGLEK 

       370        380        390        400        410        420 
NQIDEIVLVG GSTRIPKVQQ LLKEFFNGKE PSKGVNPDEA VAFGAAVQGS ILSGEGGEET 

       430        440        450        460        470        480 
KEILLLDVAP LTLGIETVGG VMTKLIPRNT VIPTKKSQVF TTYQDQQTTV TIQVFEGERS 

       490        500        510        520        530        540 
LTKDCRLLGK FDLTGIAPAP RGTPQIEVTF EVDANGILNV KAEDKASGKS EKITITNDKG 

       550        560        570        580        590        600 
RLSQEEIERM VREAEEFAEE DKKVKEKIDA RNSLETYIYN MKNQISDADK LADKLESDEK 

       610        620        630        640        650        660 
EKIEGAVKEA LEWLDDNQSA EKEDYDEKLK EVEAVCNPII TAVYQRSGGP SGESGADSED 


SEEGHDEL 

« Hide

References

[1]"A cDNA encoding the endoplasmic reticulum-luminal heat-shock protein from spinach (Spinacia oleracea L.)."
Anderson J.V., Neven L.G., Li Q.B., Haskell D.W., Guy C.L.
Plant Physiol. 104:303-304(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Bloomsdale.
Tissue: Leaf.
[2]"Structural organization of the spinach endoplasmic reticulum-luminal 70-kilodalton heat-shock cognate gene and expression of 70-kilodalton heat-shock genes during cold acclimation."
Anderson J.V., Li Q.B., Haskell D.W., Guy C.L.
Plant Physiol. 104:1359-1370(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Bloomsdale.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L23551 mRNA. Translation: AAA21808.1.
L23552 Genomic DNA. Translation: AAA21806.1.

3D structure databases

ProteinModelPortalQ42434.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ42434.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBIP_SPIOL
AccessionPrimary (citable) accession number: Q42434
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families