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Protein

Zinc finger protein ZAT12

Gene

ZAT12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor involved in light acclimation, cold and oxidative stress responses. May regulate a collection of transcripts involved in response to high-light, cold and oxidative stress.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 6123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri82 – 10423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cold acclimation Source: TAIR
  • hyperosmotic salinity response Source: TAIR
  • photosynthetic acclimation Source: TAIR
  • response to chitin Source: TAIR
  • response to cold Source: TAIR
  • response to heat Source: TAIR
  • response to light stimulus Source: TAIR
  • response to oxidative stress Source: TAIR
  • response to UV-B Source: TAIR
  • response to wounding Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZAT12
Alternative name(s):
Protein RESPONSIVE TO HIGH LIGHT 41
Gene namesi
Name:ZAT12
Synonyms:RHL41
Ordered Locus Names:At5g59820
ORF Names:MMN10.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G59820.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition, but enhanced tolerance to heat stress and increased sensitivity to salt stress.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Zinc finger protein ZAT12PRO_0000409721Add
BLAST

Proteomic databases

PaxDbiQ42410.

Expressioni

Tissue specificityi

Expressed in roots, stems and flowers.1 Publication

Inductioni

By H2O2, cold, drought, cold or heat stresses, wounding, cucumber mosaic virus (CMV), exposure to high-intensity light and low-oxygen conditions in roots.6 Publications

Gene expression databases

GenevisibleiQ42410. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G59820.1.

Structurei

3D structure databases

ProteinModelPortaliQ42410.
SMRiQ42410. Positions 29-61, 76-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 6123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri82 – 10423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000238452.
InParanoidiQ42410.
OMAiQKRVFTC.
PhylomeDBiQ42410.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAISEIKST VDVTAANCLM LLSRVGQENV DGGDQKRVFT CKTCLKQFHS
60 70 80 90 100
FQALGGHRAS HKKPNNDALS SGLMKKVKTS SHPCPICGVE FPMGQALGGH
110 120 130 140 150
MRRHRNESGA AGGALVTRAL LPEPTVTTLK KSSSGKRVAC LDLSLGMVDN
160
LNLKLELGRT VY
Length:162
Mass (Da):17,332
Last modified:November 1, 1996 - v1
Checksum:i6CF61D93EE97455A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721G → R in AAM65582 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98673 mRNA. Translation: CAA67231.1.
X98674 Genomic DNA. Translation: CAA67232.1.
AB015475 Genomic DNA. Translation: BAB08349.1.
CP002688 Genomic DNA. Translation: AED97237.1.
AY050915 mRNA. Translation: AAK93592.1.
AY133818 mRNA. Translation: AAM91752.1.
AY088036 mRNA. Translation: AAM65582.1.
RefSeqiNP_200790.1. NM_125374.2.
UniGeneiAt.24260.

Genome annotation databases

EnsemblPlantsiAT5G59820.1; AT5G59820.1; AT5G59820.
GeneIDi836103.
GrameneiAT5G59820.1; AT5G59820.1; AT5G59820.
KEGGiath:AT5G59820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98673 mRNA. Translation: CAA67231.1.
X98674 Genomic DNA. Translation: CAA67232.1.
AB015475 Genomic DNA. Translation: BAB08349.1.
CP002688 Genomic DNA. Translation: AED97237.1.
AY050915 mRNA. Translation: AAK93592.1.
AY133818 mRNA. Translation: AAM91752.1.
AY088036 mRNA. Translation: AAM65582.1.
RefSeqiNP_200790.1. NM_125374.2.
UniGeneiAt.24260.

3D structure databases

ProteinModelPortaliQ42410.
SMRiQ42410. Positions 29-61, 76-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G59820.1.

Proteomic databases

PaxDbiQ42410.

Protocols and materials databases

DNASUi836103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G59820.1; AT5G59820.1; AT5G59820.
GeneIDi836103.
GrameneiAT5G59820.1; AT5G59820.1; AT5G59820.
KEGGiath:AT5G59820.

Organism-specific databases

TAIRiAT5G59820.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000238452.
InParanoidiQ42410.
OMAiQKRVFTC.
PhylomeDBiQ42410.

Miscellaneous databases

PROiQ42410.

Gene expression databases

GenevisibleiQ42410. AT.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered protein genes and cDNA's."
    Meissner R., Michael A.J.
    Plant Mol. Biol. 33:615-624(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence features of the regions of 1,013,767 bp covered by sixteen physically assigned P1 and TAC clones."
    Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N., Tabata S.
    DNA Res. 5:297-308(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "A zinc finger protein RHL41 mediates the light acclimatization response in Arabidopsis."
    Iida A., Kazuoka T., Torikai S., Kikuchi H., Oeda K.
    Plant J. 24:191-203(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Expression profile analysis of the low-oxygen response in Arabidopsis root cultures."
    Klok E.J., Wilson I.W., Wilson D., Chapman S.C., Ewing R.M., Somerville S.C., Peacock W.J., Dolferus R., Dennis E.S.
    Plant Cell 14:2481-2494(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "The zinc finger protein Zat12 is required for cytosolic ascorbate peroxidase 1 expression during oxidative stress in Arabidopsis."
    Rizhsky L., Davletova S., Liang H., Mittler R.
    J. Biol. Chem. 279:11736-11743(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
  9. "Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis."
    Vogel J.T., Zarka D.G., Van Buskirk H.A., Fowler S.G., Thomashow M.F.
    Plant J. 41:195-211(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "The zinc-finger protein Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis."
    Davletova S., Schlauch K., Coutu J., Mittler R.
    Plant Physiol. 139:847-856(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
  11. "The transcriptional co-activator MBF1c is a key regulator of thermotolerance in Arabidopsis thaliana."
    Suzuki N., Bajad S., Shuman J., Shulaev V., Mittler R.
    J. Biol. Chem. 283:9269-9275(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HEAT STRESS.
  12. "Spermine signaling plays a significant role in the defense response of Arabidopsis thaliana to cucumber mosaic virus."
    Mitsuya Y., Takahashi Y., Berberich T., Miyazaki A., Matsumura H., Takahashi H., Terauchi R., Kusano T.
    J. Plant Physiol. 166:626-643(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY CUCUMBER MOSAIC VIRUS.

Entry informationi

Entry nameiZAT12_ARATH
AccessioniPrimary (citable) accession number: Q42410
Secondary accession number(s): Q8LA47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants overexpressing ZAT12 show thick and dark-green leaves with round shape, short petiole, elevated amounts of anthocyanins and enhanced tolerance to high-light irradiation and oxidative stress.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.