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Protein

Zinc finger protein ZAT12

Gene

ZAT12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor involved in light acclimation, cold and oxidative stress responses. May regulate a collection of transcripts involved in response to high-light, cold and oxidative stress.4 Publications

Miscellaneous

Plants overexpressing ZAT12 show thick and dark-green leaves with round shape, short petiole, elevated amounts of anthocyanins and enhanced tolerance to high-light irradiation and oxidative stress.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 61C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri82 – 104C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cold acclimation Source: TAIR
  • hyperosmotic salinity response Source: TAIR
  • photosynthetic acclimation Source: TAIR
  • response to chitin Source: TAIR
  • response to cold Source: TAIR
  • response to heat Source: TAIR
  • response to light stimulus Source: TAIR
  • response to oxidative stress Source: TAIR
  • response to UV-B Source: TAIR
  • response to wounding Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZAT12
Alternative name(s):
Protein RESPONSIVE TO HIGH LIGHT 41
Gene namesi
Name:ZAT12
Synonyms:RHL41
Ordered Locus Names:At5g59820
ORF Names:MMN10.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G59820.
TAIRilocus:2168073. AT5G59820.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition, but enhanced tolerance to heat stress and increased sensitivity to salt stress.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004097211 – 162Zinc finger protein ZAT12Add BLAST162

Proteomic databases

PaxDbiQ42410.

Expressioni

Tissue specificityi

Expressed in roots, stems and flowers.1 Publication

Inductioni

By H2O2, cold, drought, cold or heat stresses, wounding, cucumber mosaic virus (CMV), exposure to high-intensity light and low-oxygen conditions in roots.6 Publications

Gene expression databases

ExpressionAtlasiQ42410. baseline and differential.
GenevisibleiQ42410. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G59820.1.

Structurei

3D structure databases

ProteinModelPortaliQ42410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 61C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri82 – 104C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000238452.
InParanoidiQ42410.
OMAiGMVDNLN.
OrthoDBiEOG09360QH3.
PhylomeDBiQ42410.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 2 hits.
SUPFAMiSSF57667. SSF57667. 1 hit.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q42410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAISEIKST VDVTAANCLM LLSRVGQENV DGGDQKRVFT CKTCLKQFHS
60 70 80 90 100
FQALGGHRAS HKKPNNDALS SGLMKKVKTS SHPCPICGVE FPMGQALGGH
110 120 130 140 150
MRRHRNESGA AGGALVTRAL LPEPTVTTLK KSSSGKRVAC LDLSLGMVDN
160
LNLKLELGRT VY
Length:162
Mass (Da):17,332
Last modified:November 1, 1996 - v1
Checksum:i6CF61D93EE97455A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72G → R in AAM65582 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98673 mRNA. Translation: CAA67231.1.
X98674 Genomic DNA. Translation: CAA67232.1.
AB015475 Genomic DNA. Translation: BAB08349.1.
CP002688 Genomic DNA. Translation: AED97237.1.
AY050915 mRNA. Translation: AAK93592.1.
AY133818 mRNA. Translation: AAM91752.1.
AY088036 mRNA. Translation: AAM65582.1.
RefSeqiNP_200790.1. NM_125374.3.
UniGeneiAt.24260.

Genome annotation databases

EnsemblPlantsiAT5G59820.1; AT5G59820.1; AT5G59820.
GeneIDi836103.
GrameneiAT5G59820.1; AT5G59820.1; AT5G59820.
KEGGiath:AT5G59820.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZAT12_ARATH
AccessioniPrimary (citable) accession number: Q42410
Secondary accession number(s): Q8LA47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names