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Protein

Peptidyl-prolyl cis-trans isomerase CYP18-4

Gene

CYP18-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase (By similarity).By similarity

GO - Molecular functioni

  • peptide binding Source: UniProtKB-KW
  • peptidyl-prolyl cis-trans isomerase activity Source: TAIR

GO - Biological processi

  • protein folding Source: InterPro
  • signal transduction Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Enzyme and pathway databases

BioCyciARA:AT4G34870-MONOMER.
ReactomeiR-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP18-4 (EC:5.2.1.8)
Short name:
PPIase CYP18-4
Alternative name(s):
Cyclophilin of 18 kDa 4
Short name:
Cyclophilin-1
Rotamase cyclophilin-5
Gene namesi
Name:CYP18-4
Synonyms:43H1, CYP1, CYPA, ROC5
Ordered Locus Names:At4g34870
ORF Names:T11I11.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G34870.

Subcellular locationi

GO - Cellular componenti

  • apoplast Source: TAIR
  • chloroplast Source: TAIR
  • cytosol Source: TAIR
  • Golgi apparatus Source: TAIR
  • plasma membrane Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Peptidyl-prolyl cis-trans isomerase CYP18-4PRO_0000064134Add
BLAST

Proteomic databases

PaxDbiQ42406.
PRIDEiQ42406.

Expressioni

Tissue specificityi

Ubiquitous, with higher levels in roots and flowers. Confined to vascular tissues. Also detected in stigmas, base of siliques and anthers.3 Publications

Inductioni

Down-regulated by salt and cytokinin treatment.1 Publication

Gene expression databases

GenevisibleiQ42406. AT.

Interactioni

Subunit structurei

Interacts with A.tumefaciens VirD2.1 Publication

Protein-protein interaction databases

BioGridi14921. 4 interactions.
IntActiQ42406. 1 interaction.
STRINGi3702.AT4G34870.1.

Structurei

3D structure databases

ProteinModelPortaliQ42406.
SMRiQ42406. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 170164PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiQ42406.
KOiK01802.
OMAiHVERITM.
OrthoDBiEOG09360PV0.
PhylomeDBiQ42406.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q42406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPRVFFDM SLSGTPIGRI EMELFADTTP NTAENFRALC TGEKGMGKLG
60 70 80 90 100
KPLHFKGSIF HRVIPGFMCQ GGDFTAKNGT GGESIYGAKF KDENFIKKHT
110 120 130 140 150
GAGILSMANS GPNTNGSQFF ICTDKTSWLD GKHVVFGQVV KGLDVVKAIE
160 170
KVGSDSGKTS KVVTITDCGQ LS
Length:172
Mass (Da):18,378
Last modified:November 1, 1996 - v1
Checksum:iC6E082F594E73913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07276 mRNA. Translation: AAA66197.1.
U32186 Genomic DNA. Translation: AAA75512.1.
AL079347 Genomic DNA. Translation: CAB45448.1.
AL161586 Genomic DNA. Translation: CAB80204.1.
CP002687 Genomic DNA. Translation: AEE86431.1.
AY054468 mRNA. Translation: AAK96660.1.
BT006560 mRNA. Translation: AAP21368.1.
AK228231 mRNA. Translation: BAF00180.1.
AY087606 mRNA. Translation: AAM65147.1.
PIRiS50141.
RefSeqiNP_195213.1. NM_119653.3.
UniGeneiAt.1582.
At.421.

Genome annotation databases

EnsemblPlantsiAT4G34870.1; AT4G34870.1; AT4G34870.
GeneIDi829639.
GrameneiAT4G34870.1; AT4G34870.1; AT4G34870.
KEGGiath:AT4G34870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07276 mRNA. Translation: AAA66197.1.
U32186 Genomic DNA. Translation: AAA75512.1.
AL079347 Genomic DNA. Translation: CAB45448.1.
AL161586 Genomic DNA. Translation: CAB80204.1.
CP002687 Genomic DNA. Translation: AEE86431.1.
AY054468 mRNA. Translation: AAK96660.1.
BT006560 mRNA. Translation: AAP21368.1.
AK228231 mRNA. Translation: BAF00180.1.
AY087606 mRNA. Translation: AAM65147.1.
PIRiS50141.
RefSeqiNP_195213.1. NM_119653.3.
UniGeneiAt.1582.
At.421.

3D structure databases

ProteinModelPortaliQ42406.
SMRiQ42406. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14921. 4 interactions.
IntActiQ42406. 1 interaction.
STRINGi3702.AT4G34870.1.

Proteomic databases

PaxDbiQ42406.
PRIDEiQ42406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G34870.1; AT4G34870.1; AT4G34870.
GeneIDi829639.
GrameneiAT4G34870.1; AT4G34870.1; AT4G34870.
KEGGiath:AT4G34870.

Organism-specific databases

TAIRiAT4G34870.

Phylogenomic databases

eggNOGiKOG0865. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065981.
InParanoidiQ42406.
KOiK01802.
OMAiHVERITM.
OrthoDBiEOG09360PV0.
PhylomeDBiQ42406.

Enzyme and pathway databases

BioCyciARA:AT4G34870-MONOMER.
ReactomeiR-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Miscellaneous databases

PROiQ42406.

Gene expression databases

GenevisibleiQ42406. AT.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP18D_ARATH
AccessioniPrimary (citable) accession number: Q42406
Secondary accession number(s): Q0WRR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.