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Protein

Peptidyl-prolyl cis-trans isomerase CYP18-4

Gene

CYP18-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase (By similarity).By similarity

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: TAIR

GO - Biological processi

  • protein folding Source: InterPro
  • signal transduction Source: TAIR

Keywordsi

Molecular functionChaperone, Isomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-ATH-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP18-4 (EC:5.2.1.8)
Short name:
PPIase CYP18-4
Alternative name(s):
Cyclophilin of 18 kDa 4
Short name:
Cyclophilin-1
Rotamase cyclophilin-5
Gene namesi
Name:CYP18-4
Synonyms:43H1, CYP1, CYPA, ROC5
Ordered Locus Names:At4g34870
ORF Names:T11I11.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G34870
TAIRilocus:2116880 AT4G34870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641341 – 172Peptidyl-prolyl cis-trans isomerase CYP18-4Add BLAST172

Proteomic databases

PaxDbiQ42406
PRIDEiQ42406

Expressioni

Tissue specificityi

Ubiquitous, with higher levels in roots and flowers. Confined to vascular tissues. Also detected in stigmas, base of siliques and anthers.3 Publications

Inductioni

Down-regulated by salt and cytokinin treatment.1 Publication

Gene expression databases

ExpressionAtlasiQ42406 baseline and differential
GenevisibleiQ42406 AT

Interactioni

Subunit structurei

Interacts with A.tumefaciens VirD2.1 Publication

Protein-protein interaction databases

BioGridi149214 interactors.
IntActiQ42406 1 interactor.
STRINGi3702.AT4G34870.1

Structurei

3D structure databases

ProteinModelPortaliQ42406
SMRiQ42406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 170PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
HOGENOMiHOG000065981
InParanoidiQ42406
KOiK01802
OMAiFADTTPN
OrthoDBiEOG09360PV0
PhylomeDBiQ42406

Family and domain databases

Gene3Di2.40.100.101 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q42406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPRVFFDM SLSGTPIGRI EMELFADTTP NTAENFRALC TGEKGMGKLG
60 70 80 90 100
KPLHFKGSIF HRVIPGFMCQ GGDFTAKNGT GGESIYGAKF KDENFIKKHT
110 120 130 140 150
GAGILSMANS GPNTNGSQFF ICTDKTSWLD GKHVVFGQVV KGLDVVKAIE
160 170
KVGSDSGKTS KVVTITDCGQ LS
Length:172
Mass (Da):18,378
Last modified:November 1, 1996 - v1
Checksum:iC6E082F594E73913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07276 mRNA Translation: AAA66197.1
U32186 Genomic DNA Translation: AAA75512.1
AL079347 Genomic DNA Translation: CAB45448.1
AL161586 Genomic DNA Translation: CAB80204.1
CP002687 Genomic DNA Translation: AEE86431.1
AY054468 mRNA Translation: AAK96660.1
BT006560 mRNA Translation: AAP21368.1
AK228231 mRNA Translation: BAF00180.1
AY087606 mRNA Translation: AAM65147.1
PIRiS50141
RefSeqiNP_195213.1, NM_119653.4
UniGeneiAt.1582
At.421

Genome annotation databases

EnsemblPlantsiAT4G34870.1; AT4G34870.1; AT4G34870
GeneIDi829639
GrameneiAT4G34870.1; AT4G34870.1; AT4G34870
KEGGiath:AT4G34870

Similar proteinsi

Entry informationi

Entry nameiCP18D_ARATH
AccessioniPrimary (citable) accession number: Q42406
Secondary accession number(s): Q0WRR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome