ID   PRL1_ARATH              Reviewed;         486 AA.
AC   Q42384;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 68.
DE   RecName: Full=PP1/PP2A phosphatases pleiotropic regulator PRL1;
GN   Name=PRL1; OrderedLocusNames=At4g15900; ORFNames=dl3990w;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. Columbia;
RA   Nemeth K., Putnoky P., Stankovic B., Bako L., Mathur J., Redei G.P.,
RA   Schell J., Koncz C.;
RL   Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=98121113; PubMed=9461215; DOI=10.1038/35140;
RA   Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA   Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L.,
RA   Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P.,
RA   Wedler H., Wedler E., Wambutt R., Weitzenegger T., Pohl T., Terryn N.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A.,
RA   Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S.,
RA   Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B.,
RA   Mueller-Auer S., Silvey M., James R., Monfort A., Pons A.,
RA   Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P.,
RA   Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T.,
RA   Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W.,
RA   Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W.,
RA   Klosterman S., Schueller C., Chalwatzis N.;
RT   "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of
RT   Arabidopsis thaliana.";
RL   Nature 391:485-488(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=20083488; PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
RA   Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
RA   Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
RA   Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
RA   Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
RA   Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
RA   Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
RA   Langham S.-A., McCullagh B., Bilham L., Robben J.,
RA   van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
RA   Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA   Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
RA   Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
RA   De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
RA   van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
RA   Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
RA   Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
RA   Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
RA   Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA   Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
RA   Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
RA   Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
RA   Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
RA   Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
RA   Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
RA   Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
RA   Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
RA   Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
RA   Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
RA   Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
RA   Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
RA   Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
RA   Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
RA   Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
RA   Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
RA   Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
RA   Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
RA   Chen E., Marra M.A., Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:769-777(1999).
CC   -!- FUNCTION: Pleiotropic regulator of PP1 and PP2A phosphatases.
CC   -!- INTERACTION:
CC       Q8LGH4:-; NbExp=1; IntAct=EBI-1382964, EBI-1632927;
CC       P92948:AtCDC5; NbExp=1; IntAct=EBI-1382964, EBI-1382948;
CC       O04294:KAP2; NbExp=3; IntAct=EBI-1382964, EBI-1644689;
CC       Q38997:KIN10; NbExp=1; IntAct=EBI-1382964, EBI-2107143;
CC       P92958:KIN11; NbExp=1; IntAct=EBI-1382964, EBI-307202;
CC       P05771:PRKCB (xeno); NbExp=1; IntAct=EBI-1382964, EBI-706216;
CC   -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family.
CC   -!- SIMILARITY: Contains 7 WD repeats.
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DR   EMBL; X82825; CAA58032.1; -; mRNA.
DR   EMBL; X82824; CAA58031.1; -; Genomic_DNA.
DR   EMBL; Z97339; CAB10369.1; -; Genomic_DNA.
DR   EMBL; AL161542; CAB78632.1; -; Genomic_DNA.
DR   IPI; IPI00524936; -.
DR   PIR; S49820; S49820.
DR   RefSeq; NP_193325.1; -.
DR   UniGene; At.103; -.
DR   HSSP; P16649; 1ERJ.
DR   IntAct; Q42384; 9.
DR   PRIDE; Q42384; -.
DR   GeneID; 827272; -.
DR   GenomeReviews; CT486007_GR; AT4G15900.
DR   KEGG; ath:AT4G15900; -.
DR   NMPDR; fig|3702.1.peg.19342; -.
DR   GeneFarm; 2847; 267.
DR   TAIR; At4g15900; -.
DR   OMA; Q42384; ITAEADK.
DR   GermOnline; AT4G15900; Arabidopsis thaliana.
DR   GO; GO:0080008; C:CUL4 RING ubiquitin ligase complex; IPI:TAIR.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0017163; F:basal transcription repressor activity; IMP:TAIR.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0048825; P:cotyledon development; IMP:TAIR.
DR   GO; GO:0009870; P:defense response signaling pathway, resista...; IMP:TAIR.
DR   GO; GO:0010204; P:defense response signaling pathway, resista...; IMP:TAIR.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
DR   GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR   GO; GO:0009755; P:hormone-mediated signaling; IMP:TAIR.
DR   GO; GO:0048366; P:leaf development; IMP:TAIR.
DR   GO; GO:0016481; P:negative regulation of transcription; IMP:TAIR.
DR   GO; GO:0006508; P:proteolysis; IMP:TAIR.
DR   GO; GO:0009749; P:response to glucose stimulus; IMP:TAIR.
DR   GO; GO:0048364; P:root development; IMP:TAIR.
DR   GO; GO:0010182; P:sugar mediated signaling; IMP:TAIR.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019782; WD40_repeat_2.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_region.
DR   InterPro; IPR019781; WD40_repeat_sg.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   Pfam; PF00400; WD40; 6.
DR   ProDom; PD000018; WD40; 4.
DR   SMART; SM00320; WD40; 7.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Repeat; WD repeat.
FT   CHAIN         1    486       PP1/PP2A phosphatases pleiotropic
FT                                regulator PRL1.
FT                                /FTId=PRO_0000051157.
FT   REPEAT      174    204       WD 1.
FT   REPEAT      216    246       WD 2.
FT   REPEAT      258    288       WD 3.
FT   REPEAT      300    330       WD 4.
FT   REPEAT      342    371       WD 5.
FT   REPEAT      384    413       WD 6.
FT   REPEAT      433    463       WD 7.
SQ   SEQUENCE   486 AA;  54009 MW;  604D3E6FCDA8A998 CRC64;
     MPAPTTEIEP IEAQSLKKLS LKSLKRSLEL FSPVHGQFPP PDPEAKQIRL SHKMKVAFGG
     VEPVVSQPPR QPDRINEQPG PSNALSLAAP EGSKSTQKGA TESAIVVGPT LLRPILPKGL
     NYTGSSGKST TIIPANVSSY QRNLSTAALM ERIPSRWPRP EWHAPWKNYR VIQGHLGWVR
     SVAFDPSNEW FCTGSADRTI KIWDVATGVL KLTLTGHIEQ VRGLAVSNRH TYMFSAGDDK
     QVKCWDLEQN KVIRSYHGHL SGVYCLALHP TLDVLLTGGR DSVCRVWDIR TKMQIFALSG
     HDNTVCSVFT RPTDPQVVTG SHDTTIKFWD LRYGKTMSTL THHKKSVRAM TLHPKENAFA
     SASADNTKKF SLPKGEFCHN MLSQQKTIIN AMAVNEDGVM VTGGDNGSIW FWDWKSGHSF
     QQSETIVQPG SLESEAGIYA ACYDNTGSRL VTCEADKTIK MWKEDENATP ETHPINFKPP
     KEIRRF
//