Reviewed, UniProtKB/Swiss-Prot Q42384 (PRL1_ARATH)

Names and origin

Protein names

Recommended name:
    PP1/PP2A phosphatases pleiotropic regulator PRL1

Gene names

Name:	PRL1
Ordered Locus Names:	At4g15900
ORF Names:	dl3990w

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Pleiotropic regulator of PP1 and PP2A phosphatases.
Sequence similarities	Belongs to the WD repeat PRL1/PRL2 family. Contains 7 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cotyledon development Inferred from mutant phenotype. Source: TAIR defense response signaling pathway, resistance gene-dependent Inferred from mutant phenotype. Source: TAIR defense response signaling pathway, resistance gene-independent Inferred from mutant phenotype. Source: TAIR defense response to bacterium Inferred from mutant phenotype. Source: TAIR defense response to fungus Inferred from mutant phenotype. Source: TAIR hormone-mediated signaling Inferred from mutant phenotype. Source: TAIR leaf development Inferred from mutant phenotype. Source: TAIR negative regulation of transcription Inferred from mutant phenotype. Source: TAIR proteolysis Inferred from mutant phenotype. Source: TAIR response to glucose stimulus Inferred from mutant phenotype. Source: TAIR root development Inferred from mutant phenotype. Source: TAIR sugar mediated signaling Inferred from mutant phenotype. Source: TAIR
Cellular component	CUL4 RING ubiquitin ligase complex Inferred from physical interaction. Source: TAIR nucleus Inferred from direct assay. Source: TAIR
Molecular function	basal transcription repressor activity Inferred from mutant phenotype. Source: TAIR protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q8LGH4	1	EBI-1382964,EBI-1632927
AtCDC5	P92948	1	EBI-1382964,EBI-1382948
KAP2	O04294	3	EBI-1382964,EBI-1644689
KIN10	Q38997	1	EBI-1382964,EBI-2107143
KIN11	P92958	1	EBI-1382964,EBI-307202
PRKCB	P05771	1	EBI-1382964,EBI-706216	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	PP1/PP2A phosphatases pleiotropic regulator PRL1		PRO_0000051157
Regions
	Repeat	174 – 204	31	WD 1
	Repeat	216 – 246	31	WD 2
	Repeat	258 – 288	31	WD 3
	Repeat	300 – 330	31	WD 4
	Repeat	342 – 371	30	WD 5
	Repeat	384 – 413	30	WD 6
	Repeat	433 – 463	31	WD 7

Sequences

	Sequence		Length	Mass (Da)
	Q42384-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 604D3E6FCDA8A998	FASTA	486	54,009
	10 20 30 40 50 60 MPAPTTEIEP IEAQSLKKLS LKSLKRSLEL FSPVHGQFPP PDPEAKQIRL SHKMKVAFGG 70 80 90 100 110 120 VEPVVSQPPR QPDRINEQPG PSNALSLAAP EGSKSTQKGA TESAIVVGPT LLRPILPKGL 130 140 150 160 170 180 NYTGSSGKST TIIPANVSSY QRNLSTAALM ERIPSRWPRP EWHAPWKNYR VIQGHLGWVR 190 200 210 220 230 240 SVAFDPSNEW FCTGSADRTI KIWDVATGVL KLTLTGHIEQ VRGLAVSNRH TYMFSAGDDK 250 260 270 280 290 300 QVKCWDLEQN KVIRSYHGHL SGVYCLALHP TLDVLLTGGR DSVCRVWDIR TKMQIFALSG 310 320 330 340 350 360 HDNTVCSVFT RPTDPQVVTG SHDTTIKFWD LRYGKTMSTL THHKKSVRAM TLHPKENAFA 370 380 390 400 410 420 SASADNTKKF SLPKGEFCHN MLSQQKTIIN AMAVNEDGVM VTGGDNGSIW FWDWKSGHSF 430 440 450 460 470 480 QQSETIVQPG SLESEAGIYA ACYDNTGSRL VTCEADKTIK MWKEDENATP ETHPINFKPP KEIRRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Nemeth K., Putnoky P., Stankovic B., Bako L., Mathur J., Redei G.P., Schell J., Koncz C. Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: cv. Columbia.
[2]	"Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana." Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E. , Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N. Nature 391:485-488(1998) [PubMed: 9461215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R. Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X82825 mRNA. Translation: CAA58032.1. X82824 Genomic DNA. Translation: CAA58031.1. Z97339 Genomic DNA. Translation: CAB10369.1. AL161542 Genomic DNA. Translation: CAB78632.1.
IPI	IPI00524936.
PIR	S49820.
RefSeq	NP_193325.1.
UniGene	At.103
3D structure databases
HSSP	HSSP built from PDB template 1ERJ based on UniProtKB P16649.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q42384. 9 interactions.
Proteomic databases
PRIDE	Q42384.
Genome annotation databases
GeneID	827272.
GenomeReviews	Gene locus AT4G15900 in contig CT486007_GR.
KEGG	ath:AT4G15900.
NMPDR	fig|3702.1.peg.19342.
Organism-specific databases
GeneFarm	2847. 267.
TAIR	At4g15900.
Phylogenomic databases
OMA	Q42384. ITAEADK.
Gene expression databases
GermOnline	AT4G15900. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_region. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 6 hits. [Graphical view]
ProDom	PD000018. WD40. 4 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00320. WD40. 7 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 5 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRL1_ARATH

Accession

Primary (citable) accession number: Q42384

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)