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Protein

LRR receptor-like serine/threonine-protein kinase ERECTA

Gene

ERECTA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor kinase that, together with ERL1 and ERL2, regulates aerial architecture, including inflorescence (e.g. shoot apical meristem-originating organ shape, elongation of the internode and pedicels, and adaxial-abaxial polarity), and stomatal patterning (e.g. density and clustering), probably by tuning cell division and expansion. Redundantly involved with ERL1 in procambial development regulation. Forms a functional ligand-receptor pair with EPF2 (AC Q8LC53) (PubMed:22241782). Modulates plant transpiration efficiency by controlling stomatal density, leaf photosynthetic capacity, epidermal cell expansion, mesophyll cell proliferation and cell-cell contact. A phloem-specific expression of ER is sufficient for proper inflorescence architecture (PubMed:22474391). Probable major trait regulating canalization (maintenance of phenotype despite varying environment) in many aspect of the plant physiology (e.g. plant morphology, light-dependent leaves number, branch number, flowering time, phytate and mineral concentrations) by transducing microenvironmental variation into phenotypic differentiation (ecological amplifier). May maintain development integrity in heat stress conditions. Regulates cell wall composition and structure. Confers resistance to the pathogenic bacteria Ralstonia solanacearum and to the necrotrophic fungi Plectosphaerella cucumerina and Pythium irregulare, and required for callose deposition upon infection. Resistance to P.cucumerina seems cell wall-mediated.21 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei676ATPPROSITE-ProRule annotation1
Active sitei773Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi654 – 662ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • peptide binding Source: TAIR
  • protein serine/threonine kinase activity Source: UniProtKB
  • transmembrane receptor protein kinase activity Source: TAIR

GO - Biological processi

  • cellular heat acclimation Source: TAIR
  • defense response to bacterium Source: UniProtKB
  • defense response to fungus Source: TAIR
  • inflorescence morphogenesis Source: UniProtKB
  • leaf morphogenesis Source: TAIR
  • plant-type cell wall organization Source: UniProtKB
  • polarity specification of adaxial/abaxial axis Source: UniProtKB
  • regulation of cell adhesion Source: TAIR
  • regulation of cell division Source: UniProtKB
  • regulation of cell growth Source: UniProtKB
  • regulation of plant organ morphogenesis Source: TAIR
  • stomatal complex morphogenesis Source: TAIR
  • transpiration Source: UniProtKB
  • vasculature development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation, Plant defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
LRR receptor-like serine/threonine-protein kinase ERECTA1 Publication (EC:2.7.11.1)
Alternative name(s):
Protein QUANTITATIVE RESISTANCE TO PLECTOSPHAERELLA 1
Protein QUANTITATIVE RESISTANCE TO RALSTONIA SOLANACEARUM 1
Protein TRANSPIRATION EFFICIENCY 1
Gene namesi
Name:ERECTA1 Publication
Synonyms:ER, QRP1, QRS1, TE1
Ordered Locus Names:At2g26330Imported
ORF Names:T1D16.31 Publication
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G26330.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 580ExtracellularSequence analysisAdd BLAST556
Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Topological domaini602 – 976CytoplasmicSequence analysisAdd BLAST375

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: TAIR
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

In er-104 and er-105, small curly leaves and compact inflorescence with short thick siliques, increased canalization of rosette leaf number during long days.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi282M → I in er-103; compact inflorescence with short siliques, but normal leaves. 2 Publications1
Mutagenesisi489G → D in er-117; compact inflorescence with short siliques and pedicels, and susceptibility to P.cucumerina. 2 Publications1
Mutagenesisi831D → N in er-114; compact inflorescence with short siliques and pedicels, and susceptibility to P.cucumerina. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000038900025 – 976LRR receptor-like serine/threonine-protein kinase ERECTAAdd BLAST952

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Glycosylationi234N-linked (GlcNAc...)Sequence analysis1
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Glycosylationi329N-linked (GlcNAc...)Sequence analysis1
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi510N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1
Glycosylationi543N-linked (GlcNAc...)Sequence analysis1
Modified residuei645PhosphothreonineBy similarity1
Modified residuei721PhosphotyrosineBy similarity1
Modified residuei760PhosphotyrosineBy similarity1
Modified residuei815PhosphotyrosineBy similarity1
Modified residuei823PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ42371.
PRIDEiQ42371.

PTM databases

iPTMnetiQ42371.

Expressioni

Tissue specificityi

Mostly expressed in shoot apical meristems (SAM), organ primordia, flowers, siliques and young rosette leaves, and, to a lower extent, in stems and cauline leaves. Expressed in growing inflorescence stems and pedicels. Detected in epidermis, phloem and xylem.3 Publications

Developmental stagei

Strongly expressed in organ primordia and immature organs but weakly in mature organs. Observed in SAM at low levels during the vegetative growth with an increase at the transition to the reproductive growth phase. At the reproductive stage, localized in the young developing flowers. Expressed in inflorescence meristem and is up-regulated during flower initiation and formation of flower organs. Also found in cells that differentiate into pedicels.2 Publications

Gene expression databases

GenevisibleiQ42371. AT.

Interactioni

Subunit structurei

Homodimer and heterodimer with ERL1. Interacts with EPF1, EPF2, EPFL4, EPFL5 and EPFL6.3 Publications

Protein-protein interaction databases

BioGridi2525. 15 interactors.
STRINGi3702.AT2G26330.1.

Structurei

3D structure databases

ProteinModelPortaliQ42371.
SMRiQ42371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati69 – 92LRR 1Add BLAST24
Repeati93 – 115LRR 2Add BLAST23
Repeati117 – 140LRR 3Add BLAST24
Repeati141 – 163LRR 4Add BLAST23
Repeati165 – 187LRR 5Add BLAST23
Repeati189 – 212LRR 6Add BLAST24
Repeati213 – 235LRR 7Add BLAST23
Repeati237 – 259LRR 8Add BLAST23
Repeati260 – 282LRR 9Add BLAST23
Repeati284 – 306LRR 10Add BLAST23
Repeati308 – 330LRR 11Add BLAST23
Repeati332 – 355LRR 12Add BLAST24
Repeati356 – 379LRR 13Add BLAST24
Repeati380 – 401LRR 14Add BLAST22
Repeati404 – 425LRR 15Add BLAST22
Repeati428 – 449LRR 16Add BLAST22
Repeati452 – 473LRR 17Add BLAST22
Repeati476 – 498LRR 18Add BLAST23
Repeati500 – 522LRR 19Add BLAST23
Repeati523 – 545LRR 20Add BLAST23
Domaini648 – 918Protein kinasePROSITE-ProRule annotationAdd BLAST271

Domaini

The kinase domain is not required for ligand binding.1 Publication

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 20 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFET. Eukaryota.
COG0515. LUCA.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiQ42371.
KOiK20718.
OMAiCANSSCT.
OrthoDBiEOG0936023X.
PhylomeDBiQ42371.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13516. LRR_6. 2 hits.
PF13855. LRR_8. 2 hits.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 17 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFRDIVLL GFLFCLSLVA TVTSEEGATL LEIKKSFKDV NNVLYDWTTS
60 70 80 90 100
PSSDYCVWRG VSCENVTFNV VALNLSDLNL DGEISPAIGD LKSLLSIDLR
110 120 130 140 150
GNRLSGQIPD EIGDCSSLQN LDLSFNELSG DIPFSISKLK QLEQLILKNN
160 170 180 190 200
QLIGPIPSTL SQIPNLKILD LAQNKLSGEI PRLIYWNEVL QYLGLRGNNL
210 220 230 240 250
VGNISPDLCQ LTGLWYFDVR NNSLTGSIPE TIGNCTAFQV LDLSYNQLTG
260 270 280 290 300
EIPFDIGFLQ VATLSLQGNQ LSGKIPSVIG LMQALAVLDL SGNLLSGSIP
310 320 330 340 350
PILGNLTFTE KLYLHSNKLT GSIPPELGNM SKLHYLELND NHLTGHIPPE
360 370 380 390 400
LGKLTDLFDL NVANNDLEGP IPDHLSSCTN LNSLNVHGNK FSGTIPRAFQ
410 420 430 440 450
KLESMTYLNL SSNNIKGPIP VELSRIGNLD TLDLSNNKIN GIIPSSLGDL
460 470 480 490 500
EHLLKMNLSR NHITGVVPGD FGNLRSIMEI DLSNNDISGP IPEELNQLQN
510 520 530 540 550
IILLRLENNN LTGNVGSLAN CLSLTVLNVS HNNLVGDIPK NNNFSRFSPD
560 570 580 590 600
SFIGNPGLCG SWLNSPCHDS RRTVRVSISR AAILGIAIGG LVILLMVLIA
610 620 630 640 650
ACRPHNPPPF LDGSLDKPVT YSTPKLVILH MNMALHVYED IMRMTENLSE
660 670 680 690 700
KYIIGHGASS TVYKCVLKNC KPVAIKRLYS HNPQSMKQFE TELEMLSSIK
710 720 730 740 750
HRNLVSLQAY SLSHLGSLLF YDYLENGSLW DLLHGPTKKK TLDWDTRLKI
760 770 780 790 800
AYGAAQGLAY LHHDCSPRII HRDVKSSNIL LDKDLEARLT DFGIAKSLCV
810 820 830 840 850
SKSHTSTYVM GTIGYIDPEY ARTSRLTEKS DVYSYGIVLL ELLTRRKAVD
860 870 880 890 900
DESNLHHLIM SKTGNNEVME MADPDITSTC KDLGVVKKVF QLALLCTKRQ
910 920 930 940 950
PNDRPTMHQV TRVLGSFMLS EQPPAATDTS ATLAGSCYVD EYANLKTPHS
960 970
VNCSSMSASD AQLFLRFGQV ISQNSE
Length:976
Mass (Da):107,334
Last modified:November 1, 1996 - v1
Checksum:i0E51D46A4AB94C8D
GO

Polymorphismi

The cultivar Landsberg erecta (cv. Ler) derives from cv. Landsberg (cv. La-0) in which ERECTA is mutated at Ile-750 (variant er).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti750I → K Er-1 in strain: cv. Landsberg erecta; round leaves, compact inflorescence, blunt fruits, short and thick siliques and petioles, susceptibility to pathogens such as R.solanacearum, P.irregulare and P.cucumerina, abnormal cell-wall composition and increased canalization of rosette leaf number during long days. In er-101 and er-102, compact inflorescence with short siliques and pedicels. 6 Publications1
Natural varianti886V → M in strain: cv. Mt-0. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83257 Genomic DNA. Translation: BAA11869.1.
U47029 mRNA. Translation: AAC49302.1.
AC004484 Genomic DNA. Translation: AAC14518.1.
CP002685 Genomic DNA. Translation: AEC07825.1.
AY035110 mRNA. Translation: AAK59615.1.
FJ708701 mRNA. Translation: ACN59296.1.
AK221886 mRNA. Translation: BAD94220.1.
EF598332 Genomic DNA. Translation: ABR08864.1.
EF598333 Genomic DNA. Translation: ABR08865.1.
EF598334 Genomic DNA. Translation: ABR08866.1.
EF598335 Genomic DNA. Translation: ABR08867.1.
EF598336 Genomic DNA. Translation: ABR08868.1.
EF598337 Genomic DNA. Translation: ABR08869.1.
EF598338 Genomic DNA. Translation: ABR08870.1.
EF598339 Genomic DNA. Translation: ABR08871.1.
EF598340 Genomic DNA. Translation: ABR08872.1.
EF598341 Genomic DNA. Translation: ABR08873.1.
EF598342 Genomic DNA. Translation: ABR08874.1.
EF598343 Genomic DNA. Translation: ABR08875.1.
EF598344 Genomic DNA. Translation: ABR08876.1.
EF598345 Genomic DNA. Translation: ABR08877.1.
EF598346 Genomic DNA. Translation: ABR08878.1.
EF598347 Genomic DNA. Translation: ABR08879.1.
EF598348 Genomic DNA. Translation: ABR08880.1.
EF598349 Genomic DNA. Translation: ABR08881.1.
EF598350 Genomic DNA. Translation: ABR08882.1.
EF598351 Genomic DNA. Translation: ABR08883.1.
EF598352 Genomic DNA. Translation: ABR08884.1.
EF598353 Genomic DNA. Translation: ABR08885.1.
EF598354 Genomic DNA. Translation: ABR08886.1.
PIRiB84659.
RefSeqiNP_180201.1. NM_128190.3.
UniGeneiAt.10804.

Genome annotation databases

EnsemblPlantsiAT2G26330.1; AT2G26330.1; AT2G26330.
GeneIDi817173.
GrameneiAT2G26330.1; AT2G26330.1; AT2G26330.
KEGGiath:AT2G26330.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC
Protein Spotlight

A complicated affair - Issue 116 of April 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83257 Genomic DNA. Translation: BAA11869.1.
U47029 mRNA. Translation: AAC49302.1.
AC004484 Genomic DNA. Translation: AAC14518.1.
CP002685 Genomic DNA. Translation: AEC07825.1.
AY035110 mRNA. Translation: AAK59615.1.
FJ708701 mRNA. Translation: ACN59296.1.
AK221886 mRNA. Translation: BAD94220.1.
EF598332 Genomic DNA. Translation: ABR08864.1.
EF598333 Genomic DNA. Translation: ABR08865.1.
EF598334 Genomic DNA. Translation: ABR08866.1.
EF598335 Genomic DNA. Translation: ABR08867.1.
EF598336 Genomic DNA. Translation: ABR08868.1.
EF598337 Genomic DNA. Translation: ABR08869.1.
EF598338 Genomic DNA. Translation: ABR08870.1.
EF598339 Genomic DNA. Translation: ABR08871.1.
EF598340 Genomic DNA. Translation: ABR08872.1.
EF598341 Genomic DNA. Translation: ABR08873.1.
EF598342 Genomic DNA. Translation: ABR08874.1.
EF598343 Genomic DNA. Translation: ABR08875.1.
EF598344 Genomic DNA. Translation: ABR08876.1.
EF598345 Genomic DNA. Translation: ABR08877.1.
EF598346 Genomic DNA. Translation: ABR08878.1.
EF598347 Genomic DNA. Translation: ABR08879.1.
EF598348 Genomic DNA. Translation: ABR08880.1.
EF598349 Genomic DNA. Translation: ABR08881.1.
EF598350 Genomic DNA. Translation: ABR08882.1.
EF598351 Genomic DNA. Translation: ABR08883.1.
EF598352 Genomic DNA. Translation: ABR08884.1.
EF598353 Genomic DNA. Translation: ABR08885.1.
EF598354 Genomic DNA. Translation: ABR08886.1.
PIRiB84659.
RefSeqiNP_180201.1. NM_128190.3.
UniGeneiAt.10804.

3D structure databases

ProteinModelPortaliQ42371.
SMRiQ42371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2525. 15 interactors.
STRINGi3702.AT2G26330.1.

PTM databases

iPTMnetiQ42371.

Proteomic databases

PaxDbiQ42371.
PRIDEiQ42371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G26330.1; AT2G26330.1; AT2G26330.
GeneIDi817173.
GrameneiAT2G26330.1; AT2G26330.1; AT2G26330.
KEGGiath:AT2G26330.

Organism-specific databases

TAIRiAT2G26330.

Phylogenomic databases

eggNOGiENOG410IFET. Eukaryota.
COG0515. LUCA.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiQ42371.
KOiK20718.
OMAiCANSSCT.
OrthoDBiEOG0936023X.
PhylomeDBiQ42371.

Miscellaneous databases

PROiQ42371.

Gene expression databases

GenevisibleiQ42371. AT.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF13516. LRR_6. 2 hits.
PF13855. LRR_8. 2 hits.
PF08263. LRRNT_2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51450. LRR. 17 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERECT_ARATH
AccessioniPrimary (citable) accession number: Q42371
Secondary accession number(s): A5YYA0, A5YYB1, Q56WZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.