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Protein

Cytochrome b5 isoform E

Gene

CYTB5-E

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases, including fatty acid desaturases.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi64Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-196836 Vitamin C (ascorbate) metabolism
R-ATH-211945 Phase I - Functionalization of compounds

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b5 isoform E1 Publication
Short name:
AtCb5-E1 Publication
Alternative name(s):
Cytochrome b5 isoform 1
Cytochrome b5 isoform A1 Publication
Short name:
AtCb5-A1 Publication
Gene namesi
Name:CYTB5-E
Synonyms:B5-A, CB5-A1 Publication, CB5-E1 Publication
Ordered Locus Names:At5g53560
ORF Names:MNC6.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G53560
TAIRilocus:2168666 AT5G53560

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660201 – 134Cytochrome b5 isoform EAdd BLAST134

Proteomic databases

PaxDbiQ42342
PRIDEiQ42342

PTM databases

SwissPalmiQ42342

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ42342 baseline and differential
GenevisibleiQ42342 AT

Interactioni

Subunit structurei

Interacts with CER1, BI-1, FAH1 and FAH2. Interacts with AKR2A (PubMed:20215589).3 Publications

Protein-protein interaction databases

BioGridi20682, 12 interactors
IntActiQ42342, 9 interactors
STRINGi3702.AT5G53560.1

Structurei

3D structure databases

ProteinModelPortaliQ42342
SMRiQ42342
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 81Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi128 – 134AKR2A-binding sequence (ABS) required for endoplasmic reticulum membrane targeting1 Publication7

Sequence similaritiesi

Belongs to the cytochrome b5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0537 Eukaryota
COG5274 LUCA
HOGENOMiHOG000039853
InParanoidiQ42342
OMAiYHIGQID
OrthoDBiEOG09360S13
PhylomeDBiQ42342

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q42342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDRKVLSF EEVSKHNKTK DCWLIISGKV YDVTPFMDDH PGGDEVLLSS
60 70 80 90 100
TGKDATNDFE DVGHSDTARD MMDKYFIGEI DSSSVPATRT YVAPQQPAYN
110 120 130
QDKTPEFIIK ILQFLVPILI LGLALVVRHY TKKD
Length:134
Mass (Da):15,084
Last modified:January 11, 2001 - v2
Checksum:i9CC01C60F7C873FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 3MSS → ARA in CAA23377 (PubMed:8580968).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007801 mRNA Translation: BAA74839.1
AB015476 Genomic DNA Translation: BAB09732.1
CP002688 Genomic DNA Translation: AED96377.1
AY080878 mRNA Translation: AAL87348.1
AY114045 mRNA Translation: AAM45093.1
AY087070 mRNA Translation: AAM64631.1
F20001 mRNA Translation: CAA23377.1
PIRiT52469
RefSeqiNP_200168.1, NM_124736.4
UniGeneiAt.20842

Genome annotation databases

EnsemblPlantsiAT5G53560.1; AT5G53560.1; AT5G53560
GeneIDi835438
GrameneiAT5G53560.1; AT5G53560.1; AT5G53560
KEGGiath:AT5G53560

Similar proteinsi

Entry informationi

Entry nameiCYB5E_ARATH
AccessioniPrimary (citable) accession number: Q42342
Secondary accession number(s): Q9SB05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health