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Q42328

- DF195_ARATH

UniProt

Q42328 - DF195_ARATH

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Protein

Defensin-like protein 195

Gene

ATTI1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei48 – 492Reactive bondBy similarity

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro
  2. serine-type endopeptidase inhibitor activity Source: TAIR

GO - Biological processi

  1. defense response Source: TAIR
  2. defense response to fungus Source: TAIR
  3. killing of cells of other organism Source: UniProtKB-KW
  4. negative regulation of endopeptidase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Fungicide

Keywords - Biological processi

Plant defense

Protein family/group databases

MEROPSiI18.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-like protein 195
Alternative name(s):
ATTp
Trypsin inhibitor ATTI-1
diDi 4T-1
Gene namesi
Name:ATTI1
Ordered Locus Names:At2g43510
ORF Names:T01O24.25
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G43510.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 8962Defensin-like protein 195PRO_0000031093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 841 Publication
Disulfide bondi45 ↔ 691 Publication
Disulfide bondi54 ↔ 791 Publication
Disulfide bondi58 ↔ 811 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ42328.
PRIDEiQ42328.

Expressioni

Gene expression databases

GenevestigatoriQ42328.

Interactioni

Protein-protein interaction databases

BioGridi4288. 4 interactions.
IntActiQ42328. 7 interactions.
STRINGi3702.AT2G43510.1-P.

Structurei

Secondary structure

1
89
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni42 – 443
Helixi53 – 619
Beta strandi65 – 695
Beta strandi74 – 774
Beta strandi79 – 835

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JXCNMR-A22-89[»]
ProteinModelPortaliQ42328.
SMRiQ42328. Positions 23-89.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ42328.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG276553.
HOGENOMiHOG000090027.
InParanoidiQ42328.
OMAiHKNINTA.
PhylomeDBiQ42328.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view]
PfamiPF00537. Toxin_3. 1 hit.
[Graphical view]
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42328 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKAIVSIFV VFFIFFLVIS DVPEIEAQGN ECLKEYGGDV GFGFCAPRIF
60 70 80
PTICYTRCRE NKGAKGGRCR WGQGSNVKCL CDFCDDTPQ
Length:89
Mass (Da):9,885
Last modified:January 10, 2003 - v3
Checksum:iC4FA5D0B3ABB03D5
GO

Sequence cautioni

The sequence CAA86849.1 differs from that shown. Reason: Frameshift at positions 10, 12, 15 and 23.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851D → G in CAA86849. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61V → I in strain: cv. Goe-0.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46816 mRNA. Translation: CAA86849.1. Frameshift.
AJ249958 mRNA. Translation: CAB62548.1.
AJ632250 Genomic DNA. Translation: CAG15155.1.
AJ632251 Genomic DNA. Translation: CAG15160.1.
AJ632252 Genomic DNA. Translation: CAG15165.1.
AJ632253 Genomic DNA. Translation: CAG15170.1.
AJ632254 Genomic DNA. Translation: CAG15175.1.
AJ632255 Genomic DNA. Translation: CAG15181.1.
AJ632256 Genomic DNA. Translation: CAG15187.1.
AJ632257 Genomic DNA. Translation: CAG15193.1.
AJ632258 Genomic DNA. Translation: CAG15198.1.
AJ632259 Genomic DNA. Translation: CAG15203.1.
AJ632260 Genomic DNA. Translation: CAG15208.1.
AJ632261 Genomic DNA. Translation: CAG15213.1.
AJ632262 Genomic DNA. Translation: CAG15218.1.
AJ632263 Genomic DNA. Translation: CAG15223.1.
AJ632264 Genomic DNA. Translation: CAG15228.1.
AJ632265 Genomic DNA. Translation: CAG15233.1.
AJ632266 Genomic DNA. Translation: CAG15238.1.
AC002335 Genomic DNA. Translation: AAB64325.1.
CP002685 Genomic DNA. Translation: AEC10284.1.
AY050789 mRNA. Translation: AAK92724.1.
AY096456 mRNA. Translation: AAM20096.1.
PIRiA84867.
RefSeqiNP_181879.1. NM_129912.3.
UniGeneiAt.10318.

Genome annotation databases

EnsemblPlantsiAT2G43510.1; AT2G43510.1; AT2G43510.
GeneIDi818952.
KEGGiath:AT2G43510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46816 mRNA. Translation: CAA86849.1 . Frameshift.
AJ249958 mRNA. Translation: CAB62548.1 .
AJ632250 Genomic DNA. Translation: CAG15155.1 .
AJ632251 Genomic DNA. Translation: CAG15160.1 .
AJ632252 Genomic DNA. Translation: CAG15165.1 .
AJ632253 Genomic DNA. Translation: CAG15170.1 .
AJ632254 Genomic DNA. Translation: CAG15175.1 .
AJ632255 Genomic DNA. Translation: CAG15181.1 .
AJ632256 Genomic DNA. Translation: CAG15187.1 .
AJ632257 Genomic DNA. Translation: CAG15193.1 .
AJ632258 Genomic DNA. Translation: CAG15198.1 .
AJ632259 Genomic DNA. Translation: CAG15203.1 .
AJ632260 Genomic DNA. Translation: CAG15208.1 .
AJ632261 Genomic DNA. Translation: CAG15213.1 .
AJ632262 Genomic DNA. Translation: CAG15218.1 .
AJ632263 Genomic DNA. Translation: CAG15223.1 .
AJ632264 Genomic DNA. Translation: CAG15228.1 .
AJ632265 Genomic DNA. Translation: CAG15233.1 .
AJ632266 Genomic DNA. Translation: CAG15238.1 .
AC002335 Genomic DNA. Translation: AAB64325.1 .
CP002685 Genomic DNA. Translation: AEC10284.1 .
AY050789 mRNA. Translation: AAK92724.1 .
AY096456 mRNA. Translation: AAM20096.1 .
PIRi A84867.
RefSeqi NP_181879.1. NM_129912.3.
UniGenei At.10318.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JXC NMR - A 22-89 [» ]
ProteinModelPortali Q42328.
SMRi Q42328. Positions 23-89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 4288. 4 interactions.
IntActi Q42328. 7 interactions.
STRINGi 3702.AT2G43510.1-P.

Protein family/group databases

MEROPSi I18.001.

Proteomic databases

PaxDbi Q42328.
PRIDEi Q42328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G43510.1 ; AT2G43510.1 ; AT2G43510 .
GeneIDi 818952.
KEGGi ath:AT2G43510.

Organism-specific databases

TAIRi AT2G43510.

Phylogenomic databases

eggNOGi NOG276553.
HOGENOMi HOG000090027.
InParanoidi Q42328.
OMAi HKNINTA.
PhylomeDBi Q42328.

Miscellaneous databases

EvolutionaryTracei Q42328.

Gene expression databases

Genevestigatori Q42328.

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view ]
Pfami PF00537. Toxin_3. 1 hit.
[Graphical view ]
SMARTi SM00505. Knot1. 1 hit.
[Graphical view ]
SUPFAMi SSF57095. SSF57095. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of an Arabidopsis cDNA encoding a serine proteinase inhibitor ATTI-2."
    Herve C., Tremousaygue D., Lescure B.
    Plant Gene Register PGR95-011
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Arabidopsis thaliana genes expressed in the early compatible interaction with root-knot nematodes."
    Vercauteren I., van der Schueren E., Van Montagu M., Gheysen G.
    Mol. Plant Microbe Interact. 14:288-299(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Functional divergence in tandemly duplicated Arabidopsis thaliana trypsin inhibitor genes."
    Clauss M.J., Mitchell-Olds T.
    Genetics 166:1419-1436(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE FAMILY, NOMENCLATURE.
    Strain: cv. Col-1, cv. Cvi-1, cv. Di-0, cv. Fe-1a, cv. Goe-0, cv. Ita-0, cv. Kas-1, cv. Landsberg erecta, cv. Le-0, cv. Nd-1, cv. Nok-0, cv. Rsch-0, cv. Sah-0, cv. Ta-0, cv. Wassilewskija, cv. Wei-0 and cv. Wil-2.
    Tissue: Leaf.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  5. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  7. "Genome organization of more than 300 defensin-like genes in Arabidopsis."
    Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.
    Plant Physiol. 138:600-610(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  8. "NMR solution structure of ATTp, an Arabidopsis thaliana trypsin inhibitor."
    Zhao Q., Chae Y.K., Markley J.L.
    Biochemistry 41:12284-12296(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 23-89, DISULFIDE BONDS.

Entry informationi

Entry nameiDF195_ARATH
AccessioniPrimary (citable) accession number: Q42328
Secondary accession number(s): O22865, Q6ZZP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 10, 2003
Last modified: October 29, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Was (PubMed:11277426, PubMed:15082560 and PubMed:12369816) thought to be a protease inhibitor.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3