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Protein

Defensin-like protein 195

Gene

ATTI1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Was (Ref. 1, PubMed:15082560 and PubMed:12369816) thought to be a protease inhibitor.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48 – 49Reactive bondBy similarity2

GO - Molecular functioni

  • ion channel inhibitor activity Source: InterPro
  • serine-type endopeptidase inhibitor activity Source: TAIR

GO - Biological processi

  • defense response Source: TAIR
  • defense response to fungus Source: TAIR
  • killing of cells of other organism Source: UniProtKB-KW

Keywordsi

Molecular functionAntimicrobial, Fungicide
Biological processPlant defense

Protein family/group databases

MEROPSiI18.001

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-like protein 195
Alternative name(s):
ATTp
Trypsin inhibitor ATTI-1
diDi 4T-1
Gene namesi
Name:ATTI1
Ordered Locus Names:At2g43510
ORF Names:T01O24.25
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G43510
TAIRilocus:2058250 AT2G43510

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000003109328 – 89Defensin-like protein 195Add BLAST62

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 841 Publication
Disulfide bondi45 ↔ 691 Publication
Disulfide bondi54 ↔ 791 Publication
Disulfide bondi58 ↔ 811 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ42328

Expressioni

Gene expression databases

ExpressionAtlasiQ42328 baseline and differential
GenevisibleiQ42328 AT

Interactioni

Protein-protein interaction databases

BioGridi4288, 4 interactors
IntActiQ42328, 7 interactors
STRINGi3702.AT2G43510.1

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni42 – 44Combined sources3
Helixi53 – 61Combined sources9
Beta strandi65 – 69Combined sources5
Beta strandi74 – 77Combined sources4
Beta strandi79 – 83Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JXCNMR-A22-89[»]
ProteinModelPortaliQ42328
SMRiQ42328
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ42328

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JS1T Eukaryota
ENOG4111CSI LUCA
HOGENOMiHOG000090027
InParanoidiQ42328
OMAiFCAPRIL
OrthoDBiEOG09360WS9
PhylomeDBiQ42328

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q42328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAIVSIFV VFFIFFLVIS DVPEIEAQGN ECLKEYGGDV GFGFCAPRIF
60 70 80
PTICYTRCRE NKGAKGGRCR WGQGSNVKCL CDFCDDTPQ
Length:89
Mass (Da):9,885
Last modified:January 10, 2003 - v3
Checksum:iC4FA5D0B3ABB03D5
GO

Sequence cautioni

The sequence CAA86849 differs from that shown. Reason: Frameshift at positions 10, 12, 15 and 23.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85D → G in CAA86849 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti6V → I in strain: cv. Goe-0. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46816 mRNA Translation: CAA86849.1 Frameshift.
AJ249958 mRNA Translation: CAB62548.1
AJ632250 Genomic DNA Translation: CAG15155.1
AJ632251 Genomic DNA Translation: CAG15160.1
AJ632252 Genomic DNA Translation: CAG15165.1
AJ632253 Genomic DNA Translation: CAG15170.1
AJ632254 Genomic DNA Translation: CAG15175.1
AJ632255 Genomic DNA Translation: CAG15181.1
AJ632256 Genomic DNA Translation: CAG15187.1
AJ632257 Genomic DNA Translation: CAG15193.1
AJ632258 Genomic DNA Translation: CAG15198.1
AJ632259 Genomic DNA Translation: CAG15203.1
AJ632260 Genomic DNA Translation: CAG15208.1
AJ632261 Genomic DNA Translation: CAG15213.1
AJ632262 Genomic DNA Translation: CAG15218.1
AJ632263 Genomic DNA Translation: CAG15223.1
AJ632264 Genomic DNA Translation: CAG15228.1
AJ632265 Genomic DNA Translation: CAG15233.1
AJ632266 Genomic DNA Translation: CAG15238.1
AC002335 Genomic DNA Translation: AAB64325.1
CP002685 Genomic DNA Translation: AEC10284.1
AY050789 mRNA Translation: AAK92724.1
AY096456 mRNA Translation: AAM20096.1
PIRiA84867
RefSeqiNP_181879.1, NM_129912.4
UniGeneiAt.10318

Genome annotation databases

EnsemblPlantsiAT2G43510.1; AT2G43510.1; AT2G43510
GeneIDi818952
GrameneiAT2G43510.1; AT2G43510.1; AT2G43510
KEGGiath:AT2G43510

Similar proteinsi

Entry informationi

Entry nameiDF195_ARATH
AccessioniPrimary (citable) accession number: Q42328
Secondary accession number(s): O22865, Q6ZZP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 10, 2003
Last modified: April 25, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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