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Protein

Aquaporin PIP1-1

Gene

PIP1-1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Water channel required to facilitate the transport of water across cell membrane. Active as heteromers with PIP1-2, but not as homomers.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin PIP1-1
Alternative name(s):
Plasma membrane intrinsic protein 1-1
ZmPIP1-1
ZmPIP1;1
ZmPIP1a
Gene namesi
Name:PIP1-1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7721Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei92 – 11423Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi245 – 2451V → I: Active as heteromers with PIP2-5; when associated with R-249; D-250 and N-254. 1 Publication
Mutagenesisi249 – 2491Q → R: Active as heteromers with PIP2-5; when associated with V-245; D-250 and N-254. 1 Publication
Mutagenesisi250 – 2501H → D: Active as heteromers with PIP2-5; when associated with V-245; R-249; and N-254. 1 Publication
Mutagenesisi254 – 2541A → N: Active as heteromers with PIP2-5; when associated with V-245; R-249 and D-250. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Aquaporin PIP1-1PRO_0000286013Add
BLAST

Proteomic databases

PaxDbiQ41870.
PRIDEiQ41870.

Expressioni

Tissue specificityi

Highly expressed in roots, shoots and developing tassels, and at lower levels in leaves.1 Publication

Inductioni

Expressed in roots with a circadian rhythm showing an increase at the end of the night period, a peak during the first part of the light period and then a decrease.1 Publication

Interactioni

Subunit structurei

May interact with PIP1-2 to form heteromers.1 Publication

Protein-protein interaction databases

STRINGi4577.GRMZM2G174807_P01.

Structurei

3D structure databases

ProteinModelPortaliQ41870.
SMRiQ41870. Positions 39-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi115 – 1173NPA 1By similarity
Motifi236 – 2383NPA 2By similarity

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q41870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKEEDVRL GANKFSERHA IGTAAQGTDD KDYKEPPPAP LFEPGELKSW
60 70 80 90 100
SFYRPGIAEF VATFLFLYIS ILTVMGVSKS TSKCATVGIQ GIAWSFGGMI
110 120 130 140 150
LALVYCTAGI SGHINPAVTF GLFLARKLSL TRAVFYIIMQ CLGAICGRGV
160 170 180 190 200
VKGFQQGLYM GNGGRRNVVA PGYTKGDGLG AEIVGTFILV YTVFSATDAK
210 220 230 240 250
RRARDSHVPI LAPLPIGFAV FLVHLATMGI TGTGINPARS LGAAVIYNQH
260 270 280
HAWADHWIFW VGPFIGAALA AIYHQVIIRA IPFKSRS
Length:287
Mass (Da):30,885
Last modified:November 1, 1996 - v1
Checksum:i0F46696F5D64FA47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82633 mRNA. Translation: CAA57955.1.
PIRiS60455.
UniGeneiZm.160910.
Zm.181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82633 mRNA. Translation: CAA57955.1.
PIRiS60455.
UniGeneiZm.160910.
Zm.181.

3D structure databases

ProteinModelPortaliQ41870.
SMRiQ41870. Positions 39-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G174807_P01.

Proteomic databases

PaxDbiQ41870.
PRIDEiQ41870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIP11_MAIZE
AccessioniPrimary (citable) accession number: Q41870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.