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Protein

Histone H4.3

Gene

H4

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4.3
Alternative name(s):
HM4
Gene namesi
Name:H4
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001583252 – 103Histone H4.3Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei6N6-acetyllysineBy similarity1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei13N6-acetyllysineBy similarity1
Modified residuei17N6-acetyllysineBy similarity1
Modified residuei21N6-acetyllysine; alternateBy similarity1
Modified residuei21N6-methyllysine; alternate1 Publication1

Post-translational modificationi

Lys-21Me2 and Lys-21Me3 not detected.

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ41811.
PRIDEiQ41811.

PTM databases

iPTMnetiQ41811.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ41811.
SMRiQ41811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.

Family and domain databases

CDDicd00076. H4. 1 hit.
InterProiView protein in InterPro
IPR035425. CENP-T/H4_C.
IPR009072. Histone-fold.
IPR001951. Histone_H4.
PfamiView protein in Pfam
PF15511. CENP-T_C. 1 hit.
PRINTSiPR00623. HISTONEH4.
SMARTiView protein in SMART
SM00417. H4. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q41811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGARKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVRK IFLENVIRDA VTYTEHARRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,552
Last modified:January 23, 2007 - v3
Checksum:i1C8960313676F401
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84376 Genomic DNA. Translation: CAA59110.1.

Similar proteinsi

Entry informationi

Entry nameiH43_MAIZE
AccessioniPrimary (citable) accession number: Q41811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 94 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families