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Q41709

- FRI2_VIGUN

UniProt

Q41709 - FRI2_VIGUN

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Protein

Ferritin-2, chloroplastic

Gene

PFE2

Organism
Vigna unguiculata (Cowpea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Iron 1PROSITE-ProRule annotation
Metal bindingi129 – 1291Iron 1PROSITE-ProRule annotation
Metal bindingi129 – 1291Iron 2PROSITE-ProRule annotation
Metal bindingi132 – 1321Iron 1PROSITE-ProRule annotation
Metal bindingi178 – 1781Iron 2PROSITE-ProRule annotation
Metal bindingi212 – 2121Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-2, chloroplastic (EC:1.16.3.1)
Gene namesi
Name:PFE2
OrganismiVigna unguiculata (Cowpea)
Taxonomic identifieri3917 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343ChloroplastSequence AnalysisAdd
BLAST
Chaini44 – 250207Ferritin-2, chloroplasticPRO_0000008870Add
BLAST

Proteomic databases

PRIDEiQ41709.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ41709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 230154Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni44 – 7633Extension peptide (EP)Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q41709-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLRTAAASS LSLFNPNAEP SRSVPVLANN ASRLVVRAAK GSTNHRALTG
60 70 80 90 100
VIFEPFEEVK KELDLVPTVP QASLARQKYV DESEAAVNEQ INVEYNVSYV
110 120 130 140 150
YHALFAYFDR DNVALRGLAK FFKESSEEER EHAEKLMEYQ NRRGGKVKLQ
160 170 180 190 200
SIVMPLSEFD HADKGDALHA MELALSLEKL TNEKLLHLHS VATKNGDVQL
210 220 230 240 250
ADFVESEFLG EQVESIKRIS EYVAQLRRVG KGHGVWHFDQ MLLHEGGHLA
Length:250
Mass (Da):28,041
Last modified:November 1, 1998 - v2
Checksum:i7A5E7AE5024B0656
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052058 mRNA. Translation: AAC06027.1.
X67755 Genomic DNA. Translation: CAA47983.1.
PIRiPQ0614.
T08124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052058 mRNA. Translation: AAC06027.1 .
X67755 Genomic DNA. Translation: CAA47983.1 .
PIRi PQ0614.
T08124.

3D structure databases

ProteinModelPortali Q41709.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q41709.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Occurrence and expression of members of the ferritin gene family in cowpeas."
    Wardrop A.J., Wicks R.E., Entsch B.
    Biochem. J. 337:523-530(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. N41.
    Tissue: Leaf.
  2. "Functional genes found for three different plant ferritin subunits in the legume, Vigna unguiculata."
    Wicks R.E., Entsch B.
    Biochem. Biophys. Res. Commun. 192:813-819(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 53-123.
    Strain: cv. N41.
    Tissue: Leaf.

Entry informationi

Entry nameiFRI2_VIGUN
AccessioniPrimary (citable) accession number: Q41709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3