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Q41709

- FRI2_VIGUN

UniProt

Q41709 - FRI2_VIGUN

Protein

Ferritin-2, chloroplastic

Gene

PFE2

Organism
Vigna unguiculata (Cowpea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi94 – 941Iron 1PROSITE-ProRule annotation
    Metal bindingi129 – 1291Iron 1PROSITE-ProRule annotation
    Metal bindingi129 – 1291Iron 2PROSITE-ProRule annotation
    Metal bindingi132 – 1321Iron 1PROSITE-ProRule annotation
    Metal bindingi178 – 1781Iron 2PROSITE-ProRule annotation
    Metal bindingi212 – 2121Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin-2, chloroplastic (EC:1.16.3.1)
    Gene namesi
    Name:PFE2
    OrganismiVigna unguiculata (Cowpea)
    Taxonomic identifieri3917 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343ChloroplastSequence AnalysisAdd
    BLAST
    Chaini44 – 250207Ferritin-2, chloroplasticPRO_0000008870Add
    BLAST

    Proteomic databases

    PRIDEiQ41709.
    ProMEXiQ41709.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ41709.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini77 – 230154Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni44 – 7633Extension peptide (EP)Add
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q41709-1 [UniParc]FASTAAdd to Basket

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    MLLRTAAASS LSLFNPNAEP SRSVPVLANN ASRLVVRAAK GSTNHRALTG    50
    VIFEPFEEVK KELDLVPTVP QASLARQKYV DESEAAVNEQ INVEYNVSYV 100
    YHALFAYFDR DNVALRGLAK FFKESSEEER EHAEKLMEYQ NRRGGKVKLQ 150
    SIVMPLSEFD HADKGDALHA MELALSLEKL TNEKLLHLHS VATKNGDVQL 200
    ADFVESEFLG EQVESIKRIS EYVAQLRRVG KGHGVWHFDQ MLLHEGGHLA 250
    Length:250
    Mass (Da):28,041
    Last modified:November 1, 1998 - v2
    Checksum:i7A5E7AE5024B0656
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF052058 mRNA. Translation: AAC06027.1.
    X67755 Genomic DNA. Translation: CAA47983.1.
    PIRiPQ0614.
    T08124.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF052058 mRNA. Translation: AAC06027.1 .
    X67755 Genomic DNA. Translation: CAA47983.1 .
    PIRi PQ0614.
    T08124.

    3D structure databases

    ProteinModelPortali Q41709.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q41709.
    ProMEXi Q41709.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Occurrence and expression of members of the ferritin gene family in cowpeas."
      Wardrop A.J., Wicks R.E., Entsch B.
      Biochem. J. 337:523-530(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. N41.
      Tissue: Leaf.
    2. "Functional genes found for three different plant ferritin subunits in the legume, Vigna unguiculata."
      Wicks R.E., Entsch B.
      Biochem. Biophys. Res. Commun. 192:813-819(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 53-123.
      Strain: cv. N41.
      Tissue: Leaf.

    Entry informationi

    Entry nameiFRI2_VIGUN
    AccessioniPrimary (citable) accession number: Q41709
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3