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Q41709 (FRI2_VIGUN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin-2, chloroplastic

EC=1.16.3.1
Gene names
Name:PFE2
OrganismVigna unguiculata (Cowpea)
Taxonomic identifier3917 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Subcellular location

Plastidchloroplast.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4343Chloroplast Potential
Chain44 – 250207Ferritin-2, chloroplastic
PRO_0000008870

Regions

Domain77 – 230154Ferritin-like diiron
Region44 – 7633Extension peptide (EP)

Sites

Metal binding941Iron 1 By similarity
Metal binding1291Iron 1 By similarity
Metal binding1291Iron 2 By similarity
Metal binding1321Iron 1 By similarity
Metal binding1781Iron 2 By similarity
Metal binding2121Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q41709 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: 7A5E7AE5024B0656

FASTA25028,041
        10         20         30         40         50         60 
MLLRTAAASS LSLFNPNAEP SRSVPVLANN ASRLVVRAAK GSTNHRALTG VIFEPFEEVK 

        70         80         90        100        110        120 
KELDLVPTVP QASLARQKYV DESEAAVNEQ INVEYNVSYV YHALFAYFDR DNVALRGLAK 

       130        140        150        160        170        180 
FFKESSEEER EHAEKLMEYQ NRRGGKVKLQ SIVMPLSEFD HADKGDALHA MELALSLEKL 

       190        200        210        220        230        240 
TNEKLLHLHS VATKNGDVQL ADFVESEFLG EQVESIKRIS EYVAQLRRVG KGHGVWHFDQ 

       250 
MLLHEGGHLA 

« Hide

References

[1]"Occurrence and expression of members of the ferritin gene family in cowpeas."
Wardrop A.J., Wicks R.E., Entsch B.
Biochem. J. 337:523-530(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. N41.
Tissue: Leaf.
[2]"Functional genes found for three different plant ferritin subunits in the legume, Vigna unguiculata."
Wicks R.E., Entsch B.
Biochem. Biophys. Res. Commun. 192:813-819(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 53-123.
Strain: cv. N41.
Tissue: Leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF052058 mRNA. Translation: AAC06027.1.
X67755 Genomic DNA. Translation: CAA47983.1.
PIRPQ0614.
T08124.

3D structure databases

ProteinModelPortalQ41709.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ41709.
ProMEXQ41709.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRI2_VIGUN
AccessionPrimary (citable) accession number: Q41709
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families