Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot Q41639 (CDC2_VIGAC)

Last modified June 16, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cell division control protein 2 homolog
    EC=2.7.11.22
    EC=2.7.11.23
Alternative name(s):
    p34cdc2
Gene names
Name: CDC2
OrganismVigna aconitifolia (Mothbean)
Taxonomic identifier3918 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonscore eudicotyledonsrosidseurosids IFabalesFabaceaePapilionoideaePhaseoleaeVigna

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Cell division control protein 2 homolog
PRO_0000085760

Regions

Domain4 – 287284Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site331ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1611Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
Q41639-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C8AF96B32389E312

FASTA29433,983
        10         20         30         40         50         60 
MEQYEKVEKI GEGTYGVVYK ARDRVTNETI ALKKIRLEQE DEGVPSTAIR EISLLKEMQH 

        70         80         90        100        110        120 
RNIVRLQDVV HSEKRLYLVF EYLDLDLKKH MDSSPEFVKD PRQVKMFLYQ ILCGIAYCHS 

       130        140        150        160        170        180 
HRVLHRDLKP QNLLIDRRTN SLKLADFGLA RAFGIPVRTF THEVVTLWYR APEILLGSRH 

       190        200        210        220        230        240 
YSTPVDVWSV GCIFAEMVNR RPLFPGDSEI DELFKIFRIL GTPNEETWPG VTALPDFKST 

       250        260        270        280        290 
FPKWPPKDLA TVVPNLDAAG LNLLSSMLCL DPSKRITARI AVEHEYFKDI KFVP 

« Hide

References

[1]"p34cdc2 protein kinase homolog from mothbean (Vigna aconitifolia)."
Hong Z., Miao G.-H., Verma D.P.S.
Plant Physiol. 101:1399-1400(1993) [PubMed: 8310070] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Root nodule.

Cross-references

Sequence databases

M99497 mRNA. Translation: AAA34241.1.
PIRJQ2243.

3D structure databases

HSSPHSSP built from PDB template 1H06 based on UniProtKB P24941.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.7.11.22. 18771.
2.7.11.23. 18771.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC2_VIGAC
AccessionPrimary (citable) accession number: Q41639
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents