Reviewed,
UniProtKB/Swiss-Prot Q41452 (FLS_SOLTU)
Last modified
November 25, 2008.
Version 49.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Flavonol synthase/flavanone 3-hydroxylase Short name=FLS EC=1.14.11.23 EC=1.14.11.9 |
| Organism | Solanum tuberosum (Potato) |
| Taxonomic identifier | 4113 [NCBI] |
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum |
Protein attributes
| Sequence length | 349 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. |
| Catalytic activity | A dihydroflavonol + 2-oxoglutarate + O(2) = a flavonol + succinate + CO(2) + H(2)O. A flavanone + 2-oxoglutarate + O(2) = a dihydroflavonol + succinate + CO(2). |
| Cofactor | Binds 1 iron ion per subunit By similarity. Binds 1 ascorbate molecule per subunit By similarity. |
| Pathway | |
| Subcellular location | |
| Developmental stage | Temporally expressed during flower development. |
| Sequence similarities | Belongs to the iron/ascorbate-dependent oxidoreductase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Flavonoid biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Iron Metal-binding Vitamin C |
| Molecular function | Dioxygenase Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | flavonoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | L-ascorbic acid binding Inferred from electronic annotation. Source: UniProtKB-KW flavonol synthase activityInferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: InterPro naringenin 3-dioxygenase activityInferred from electronic annotation. Source: EC oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Regulation of flavonol biosynthesis during anther and pistil development, and during pollen tube growth in Solanum tuberosum." van Eldik G.J., Ruiter R.K., Reijnen W.H., van Herpen M.M.A., Schrauwen J.A.M., Wullems G.J. Plant J. 11:105-113(1997) [PubMed: 9025306] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pistil. |
Cross-references
Sequence databases | |
|---|---|
| X92178 mRNA. Translation: CAA63092.1. | |
| PIR | T07373. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GP6 based on UniProtKB Q96323. |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR005123. 2OG-FeII_Oase. IPR002283. Isopenicillin-N_synthase. [Graphical view] |
| Pfam | PF03171. 2OG-FeII_Oxy. 1 hit. [Graphical view] |
| PRINTS | PR00682. IPNSYNTHASE. |
| ProtoNet | Search... |
Entry information
| Entry name | FLS_SOLTU | ||||||||
| Accession | Primary (citable) accession number: Q41452 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


