Q41452 (FLS_SOLTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 71.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Flavonol synthase/flavanone 3-hydroxylase Short name=FLS EC=1.14.11.23 EC=1.14.11.9 |
| Organism | Solanum tuberosum (Potato) [Reference proteome] |
| Taxonomic identifier | 4113 [NCBI] |
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum![]() |
Protein attributes
| Sequence length | 349 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. |
| Catalytic activity | A dihydroflavonol + 2-oxoglutarate + O2 = a flavonol + succinate + CO2 + H2O. A flavanone + 2-oxoglutarate + O2 = a dihydroflavonol + succinate + CO2. |
| Cofactor | Binds 1 iron ion per subunit By similarity. Binds 1 ascorbate molecule per subunit By similarity. |
| Pathway | |
| Subcellular location | |
| Developmental stage | Temporally expressed during flower development. |
| Sequence similarities | Belongs to the iron/ascorbate-dependent oxidoreductase family. Contains 1 Fe2OG dioxygenase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Flavonoid biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Iron Metal-binding Vitamin C |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | flavonol biosynthetic process Inferred from electronic annotation. Source: GOC |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | L-ascorbic acid binding Inferred from electronic annotation. Source: UniProtKB-KW flavonol synthase activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW naringenin 3-dioxygenase activityInferred from electronic annotation. Source: EC oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 349 | 349 | Flavonol synthase/flavanone 3-hydroxylase | PRO_0000067297 | |||||
Regions | |||||||||
| Domain | 213 – 310 | 98 | Fe2OG dioxygenase | ||||||
Sites | |||||||||
| Metal binding | 238 | 1 | Iron By similarity | ||||||
| Metal binding | 240 | 1 | Iron By similarity | ||||||
| Metal binding | 291 | 1 | Iron By similarity | ||||||
Sequences
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References
| [1] | "Regulation of flavonol biosynthesis during anther and pistil development, and during pollen tube growth in Solanum tuberosum." van Eldik G.J., Ruiter R.K., Reijnen W.H., van Herpen M.M.A., Schrauwen J.A.M., Wullems G.J. Plant J. 11:105-113(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pistil. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X92178 mRNA. Translation: CAA63092.1. |
| PIR | T07373. |
3D structure databases | |
| ProteinModelPortal | Q41452. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Enzyme and pathway databases | |
| UniPathway | UPA00154. |
Family and domain databases | |
| InterPro | IPR026992. DIOX_N. IPR005123. Oxoglu/Fe-dep_dioxygenase. [Graphical view] |
| Pfam | PF03171. 2OG-FeII_Oxy. 1 hit. PF14226. DIOX_N. 1 hit. [Graphical view] |
| PROSITE | PS51471. FE2OG_OXY. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FLS_SOLTU | ||||||||
| Accession | Primary (citable) accession number: Q41452 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
