Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ethylene receptor 1

Gene

ETR1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactori

Cu cationBy similarityNote: Binds 1 copper ion per dimer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80CopperBy similarity1
Metal bindingi84CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase

Keywords - Biological processi

Ethylene signaling pathway, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Copper, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 3101.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene receptor 1 (EC:2.7.13.3)
Short name:
LeETR1
Gene namesi
Name:ETR1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814161 – 754Ethylene receptor 1Add BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18InterchainBy similarity
Disulfide bondi20InterchainBy similarity
Modified residuei367Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei6774-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ41342.

Expressioni

Tissue specificityi

Leaves, flowers and fruits.

Developmental stagei

Expressed at all stages.

Inductioni

Constitutively expressed and accumulation not affected by ethylene, silver ions or auxin.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
int106B6GVA22EBI-2407792,EBI-2407896

Protein-protein interaction databases

IntActiQ41342. 2 interactors.
STRINGi4081.Solyc12g011330.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ41342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 321GAFAdd BLAST149
Domaini364 – 601Histidine kinasePROSITE-ProRule annotationAdd BLAST238
Domaini629 – 746Response regulatoryPROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Belongs to the ethylene receptor family.Curated
Contains 1 GAF domain.Curated
Contains 1 histidine kinase domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0519. Eukaryota.
COG0642. LUCA.
InParanoidiQ41342.
KOiK14509.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q41342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLLRMNRL LSSIVESCNC IIDPQLPADD LLMKYQYISD FFIALAYFSI
60 70 80 90 100
PVELIYFVKK SAVFPYRWVL VQFGAFIVLC GATHLINLWT FNMHTRNVAI
110 120 130 140 150
VMTTPKALTA LVSCITALML VHIIPDLLSV KTRELFLKKK AAQLDREMGI
160 170 180 190 200
IRTQEETGRH VRMLTHEIRS TLDRHTILKT TLVELGRTLA LEECALWMPT
210 220 230 240 250
RTGLELQLSY TLRHQNPVGL TVPIQLPVIN QVFGTNHVVK ISPNSPVARL
260 270 280 290 300
RPAGKYMPGE VVAVRVPLLH LSNFQINDWP ELSTKRYALM VLMLPSDSAR
310 320 330 340 350
QWHVHELELV EVVADQVAVA LSHAAILEES MRARDLLMEQ NVALDLARRE
360 370 380 390 400
AEMAVRARND FLAVMNHEMR TPMHAIIALS SLLQETDLTP EQRLMVETIL
410 420 430 440 450
KSSNLLATLI NDVLDLSRLE DGSLQLDIGT FNLHALFREV HSLIKPIASV
460 470 480 490 500
KKLFVTLSLS SDLPEYVIGD EKRLMQILLN VVGNAVKFSK EGNVSISAFV
510 520 530 540 550
AKSDSLRDPR APEFFAVPSE NHFYLRVQIK DTGIGITPQD IPNLFSKFTQ
560 570 580 590 600
SQALATTNSG GTGLGLAICK RFVNLMEGHI WIESEGLGKG STAIFIIKLG
610 620 630 640 650
IPGRANESKL PFVTKLPANH TQMSFQGLKV LVMDENGVSR MVTKGLLTHL
660 670 680 690 700
GCDVTTVGSR DECLRVVTHE HKVVIMDVSM QGIDCYEVAV VIHERFGKRH
710 720 730 740 750
GRPLIVALTG NTDRVTKENC MRVGMDGVIL KPVSVYKMRS VLSELLEHGV

VLES
Length:754
Mass (Da):84,202
Last modified:November 1, 1996 - v1
Checksum:iD7443B6517781D0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105P → A in AAC02213 (PubMed:9721682).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41103 mRNA. Translation: AAA85479.1.
AF043084 mRNA. Translation: AAC02213.1.
PIRiS71783.
T52288.
RefSeqiNP_001234149.1. NM_001247220.2.
UniGeneiLes.3490.

Genome annotation databases

GeneIDi606298.
KEGGisly:606298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41103 mRNA. Translation: AAA85479.1.
AF043084 mRNA. Translation: AAC02213.1.
PIRiS71783.
T52288.
RefSeqiNP_001234149.1. NM_001247220.2.
UniGeneiLes.3490.

3D structure databases

ProteinModelPortaliQ41342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ41342. 2 interactors.
STRINGi4081.Solyc12g011330.2.1.

Proteomic databases

PaxDbiQ41342.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi606298.
KEGGisly:606298.

Phylogenomic databases

eggNOGiKOG0519. Eukaryota.
COG0642. LUCA.
InParanoidiQ41342.
KOiK14509.

Enzyme and pathway databases

BRENDAi2.7.13.3. 3101.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR014525. ETR.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETR1_SOLLC
AccessioniPrimary (citable) accession number: Q41342
Secondary accession number(s): O49186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.