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Q41342 (ETR1_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ethylene receptor 1

Short name=LeETR1
EC=2.7.13.3
Gene names
Name:ETR1
OrganismSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [Reference proteome]
Taxonomic identifier4081 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway By similarity.

Catalytic activity

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactor

Binds 1 copper ion per dimer By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Leaves, flowers and fruits.

Developmental stage

Expressed at all stages.

Induction

Constitutively expressed and accumulation not affected by ethylene, silver ions or auxin.

Post-translational modification

Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain By similarity.

Sequence similarities

Belongs to the ethylene receptor family.

Contains 1 GAF domain.

Contains 1 histidine kinase domain.

Contains 1 response regulatory domain.

Ontologies

Keywords
   Biological processEthylene signaling pathway
Two-component regulatory system
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Copper
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Transferase
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to iron ion

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

cytokinin metabolic process

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

defense response by callose deposition in cell wall

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

defense response to bacterium

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

detection of ethylene stimulus

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

ethylene-activated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

hydrogen peroxide biosynthetic process

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

regulation of seedling development

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

regulation of stomatal movement

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to abscisic acid

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to auxin

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to gibberellin

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to heat

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to insect

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to molecule of bacterial origin

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to salt stress

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ethylene binding

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphorelay response regulator activity

Inferred from electronic annotation. Source: InterPro

phosphorelay sensor kinase activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 19036844. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

int106B6GVA22EBI-2407792,EBI-2407896

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 754754Ethylene receptor 1
PRO_0000081416

Regions

Transmembrane38 – 5821Helical; Potential
Transmembrane68 – 8821Helical; Potential
Transmembrane108 – 12821Helical; Potential
Domain173 – 321149GAF
Domain364 – 601238Histidine kinase
Domain629 – 746118Response regulatory

Sites

Metal binding801Copper By similarity
Metal binding841Copper By similarity

Amino acid modifications

Modified residue3671Phosphohistidine; by autocatalysis By similarity
Modified residue67714-aspartylphosphate By similarity
Disulfide bond18Interchain By similarity
Disulfide bond20Interchain By similarity

Experimental info

Sequence conflict1051P → A in AAC02213. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q41342 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D7443B6517781D0A

FASTA75484,202
        10         20         30         40         50         60 
MGSLLRMNRL LSSIVESCNC IIDPQLPADD LLMKYQYISD FFIALAYFSI PVELIYFVKK 

        70         80         90        100        110        120 
SAVFPYRWVL VQFGAFIVLC GATHLINLWT FNMHTRNVAI VMTTPKALTA LVSCITALML 

       130        140        150        160        170        180 
VHIIPDLLSV KTRELFLKKK AAQLDREMGI IRTQEETGRH VRMLTHEIRS TLDRHTILKT 

       190        200        210        220        230        240 
TLVELGRTLA LEECALWMPT RTGLELQLSY TLRHQNPVGL TVPIQLPVIN QVFGTNHVVK 

       250        260        270        280        290        300 
ISPNSPVARL RPAGKYMPGE VVAVRVPLLH LSNFQINDWP ELSTKRYALM VLMLPSDSAR 

       310        320        330        340        350        360 
QWHVHELELV EVVADQVAVA LSHAAILEES MRARDLLMEQ NVALDLARRE AEMAVRARND 

       370        380        390        400        410        420 
FLAVMNHEMR TPMHAIIALS SLLQETDLTP EQRLMVETIL KSSNLLATLI NDVLDLSRLE 

       430        440        450        460        470        480 
DGSLQLDIGT FNLHALFREV HSLIKPIASV KKLFVTLSLS SDLPEYVIGD EKRLMQILLN 

       490        500        510        520        530        540 
VVGNAVKFSK EGNVSISAFV AKSDSLRDPR APEFFAVPSE NHFYLRVQIK DTGIGITPQD 

       550        560        570        580        590        600 
IPNLFSKFTQ SQALATTNSG GTGLGLAICK RFVNLMEGHI WIESEGLGKG STAIFIIKLG 

       610        620        630        640        650        660 
IPGRANESKL PFVTKLPANH TQMSFQGLKV LVMDENGVSR MVTKGLLTHL GCDVTTVGSR 

       670        680        690        700        710        720 
DECLRVVTHE HKVVIMDVSM QGIDCYEVAV VIHERFGKRH GRPLIVALTG NTDRVTKENC 

       730        740        750 
MRVGMDGVIL KPVSVYKMRS VLSELLEHGV VLES 

« Hide

References

[1]"The mRNA for an ETR1 homologue in tomato is constitutively expressed in vegetative and reproductive tissues."
Zhou D., Kalaitzis P., Mattoo A.K., Tucker M.L.
Plant Mol. Biol. 30:1331-1338(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Rutgers.
Tissue: Abscission zone and Fruit.
[2]"Differential regulation of the tomato ETR gene family throughout plant development."
Lashbrook C.C., Tieman D.M., Klee H.J.
Plant J. 15:243-252(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Rutgers.
Tissue: Root.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U41103 mRNA. Translation: AAA85479.1.
AF043084 mRNA. Translation: AAC02213.1.
PIRS71783.
T52288.
RefSeqNP_001234149.1. NM_001247220.1.
UniGeneLes.3490.

3D structure databases

ProteinModelPortalQ41342.
SMRQ41342. Positions 624-753.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ41342. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsSolyc12g011330.2.1; Solyc12g011330.2.1; Solyc12g011330.2.
GeneID606298.
KEGGsly:606298.

Phylogenomic databases

KOK14509.

Family and domain databases

Gene3D1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR003661. EnvZ-like_dim/P.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR014525. Sig_transdc_His_kin_hyb_Et-sen.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameETR1_SOLLC
AccessionPrimary (citable) accession number: Q41342
Secondary accession number(s): O49186
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families