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Q41342

- ETR1_SOLLC

UniProt

Q41342 - ETR1_SOLLC

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Protein
Ethylene receptor 1
Gene
ETR1
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway By similarity.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Cofactori

Binds 1 copper ion per dimer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Copper By similarity
Metal bindingi84 – 841Copper By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ethylene binding Source: EnsemblPlants/Gramene
  3. metal ion binding Source: UniProtKB-KW
  4. phosphorelay response regulator activity Source: InterPro
  5. phosphorelay sensor kinase activity Source: InterPro
  6. protein binding Source: IntAct

GO - Biological processi

  1. cellular response to iron ion Source: EnsemblPlants/Gramene
  2. cytokinin metabolic process Source: EnsemblPlants/Gramene
  3. defense response by callose deposition in cell wall Source: EnsemblPlants/Gramene
  4. defense response to bacterium Source: EnsemblPlants/Gramene
  5. detection of ethylene stimulus Source: EnsemblPlants/Gramene
  6. ethylene-activated signaling pathway Source: UniProtKB-KW
  7. hydrogen peroxide biosynthetic process Source: EnsemblPlants/Gramene
  8. regulation of seedling development Source: EnsemblPlants/Gramene
  9. regulation of stomatal movement Source: EnsemblPlants/Gramene
  10. response to abscisic acid Source: EnsemblPlants/Gramene
  11. response to auxin Source: EnsemblPlants/Gramene
  12. response to gibberellin Source: EnsemblPlants/Gramene
  13. response to heat Source: EnsemblPlants/Gramene
  14. response to insect Source: EnsemblPlants/Gramene
  15. response to molecule of bacterial origin Source: EnsemblPlants/Gramene
  16. response to salt stress Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase

Keywords - Biological processi

Ethylene signaling pathway, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Copper, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene receptor 1 (EC:2.7.13.3)
Short name:
LeETR1
Gene namesi
Name:ETR1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Chromosome 12

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821Helical; Reviewed prediction
Add
BLAST
Transmembranei68 – 8821Helical; Reviewed prediction
Add
BLAST
Transmembranei108 – 12821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Ethylene receptor 1
PRO_0000081416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi18 – 18Interchain By similarity
Disulfide bondi20 – 20Interchain By similarity
Modified residuei367 – 3671Phosphohistidine; by autocatalysis By similarity
Modified residuei677 – 67714-aspartylphosphate By similarity

Post-translational modificationi

Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain By similarity.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Tissue specificityi

Leaves, flowers and fruits.

Developmental stagei

Expressed at all stages.

Inductioni

Constitutively expressed and accumulation not affected by ethylene, silver ions or auxin.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
int106B6GVA22EBI-2407792,EBI-2407896

Protein-protein interaction databases

IntActiQ41342. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ41342.
SMRiQ41342. Positions 624-753.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini173 – 321149GAF
Add
BLAST
Domaini364 – 601238Histidine kinase
Add
BLAST
Domaini629 – 746118Response regulatory
Add
BLAST

Sequence similaritiesi

Belongs to the ethylene receptor family.
Contains 1 GAF domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14509.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003661. EnvZ-like_dim/P.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR014525. Sig_transdc_His_kin_hyb_Et-sen.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q41342-1 [UniParc]FASTAAdd to Basket

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MGSLLRMNRL LSSIVESCNC IIDPQLPADD LLMKYQYISD FFIALAYFSI    50
PVELIYFVKK SAVFPYRWVL VQFGAFIVLC GATHLINLWT FNMHTRNVAI 100
VMTTPKALTA LVSCITALML VHIIPDLLSV KTRELFLKKK AAQLDREMGI 150
IRTQEETGRH VRMLTHEIRS TLDRHTILKT TLVELGRTLA LEECALWMPT 200
RTGLELQLSY TLRHQNPVGL TVPIQLPVIN QVFGTNHVVK ISPNSPVARL 250
RPAGKYMPGE VVAVRVPLLH LSNFQINDWP ELSTKRYALM VLMLPSDSAR 300
QWHVHELELV EVVADQVAVA LSHAAILEES MRARDLLMEQ NVALDLARRE 350
AEMAVRARND FLAVMNHEMR TPMHAIIALS SLLQETDLTP EQRLMVETIL 400
KSSNLLATLI NDVLDLSRLE DGSLQLDIGT FNLHALFREV HSLIKPIASV 450
KKLFVTLSLS SDLPEYVIGD EKRLMQILLN VVGNAVKFSK EGNVSISAFV 500
AKSDSLRDPR APEFFAVPSE NHFYLRVQIK DTGIGITPQD IPNLFSKFTQ 550
SQALATTNSG GTGLGLAICK RFVNLMEGHI WIESEGLGKG STAIFIIKLG 600
IPGRANESKL PFVTKLPANH TQMSFQGLKV LVMDENGVSR MVTKGLLTHL 650
GCDVTTVGSR DECLRVVTHE HKVVIMDVSM QGIDCYEVAV VIHERFGKRH 700
GRPLIVALTG NTDRVTKENC MRVGMDGVIL KPVSVYKMRS VLSELLEHGV 750
VLES 754
Length:754
Mass (Da):84,202
Last modified:November 1, 1996 - v1
Checksum:iD7443B6517781D0A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051P → A in AAC02213. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41103 mRNA. Translation: AAA85479.1.
AF043084 mRNA. Translation: AAC02213.1.
PIRiS71783.
T52288.
RefSeqiNP_001234149.1. NM_001247220.1.
UniGeneiLes.3490.

Genome annotation databases

EnsemblPlantsiSolyc12g011330.2.1; Solyc12g011330.2.1; Solyc12g011330.2.
GeneIDi606298.
KEGGisly:606298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41103 mRNA. Translation: AAA85479.1 .
AF043084 mRNA. Translation: AAC02213.1 .
PIRi S71783.
T52288.
RefSeqi NP_001234149.1. NM_001247220.1.
UniGenei Les.3490.

3D structure databases

ProteinModelPortali Q41342.
SMRi Q41342. Positions 624-753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q41342. 2 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi Solyc12g011330.2.1 ; Solyc12g011330.2.1 ; Solyc12g011330.2 .
GeneIDi 606298.
KEGGi sly:606298.

Phylogenomic databases

KOi K14509.

Family and domain databases

Gene3Di 1.10.287.130. 1 hit.
3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR003661. EnvZ-like_dim/P.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR014525. Sig_transdc_His_kin_hyb_Et-sen.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view ]
Pfami PF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view ]
PIRSFi PIRSF026389. Ethyln_sen_HK. 1 hit.
PRINTSi PR00344. BCTRLSENSOR.
SMARTi SM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mRNA for an ETR1 homologue in tomato is constitutively expressed in vegetative and reproductive tissues."
    Zhou D., Kalaitzis P., Mattoo A.K., Tucker M.L.
    Plant Mol. Biol. 30:1331-1338(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Rutgers.
    Tissue: Abscission zone and Fruit.
  2. "Differential regulation of the tomato ETR gene family throughout plant development."
    Lashbrook C.C., Tieman D.M., Klee H.J.
    Plant J. 15:243-252(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Rutgers.
    Tissue: Root.

Entry informationi

Entry nameiETR1_SOLLC
AccessioniPrimary (citable) accession number: Q41342
Secondary accession number(s): O49186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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