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Q41342

- ETR1_SOLLC

UniProt

Q41342 - ETR1_SOLLC

Protein

Ethylene receptor 1

Gene

ETR1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May act early in the ethylene signal transduction pathway, possibly as an ethylene receptor, or as a regulator of the pathway.By similarity

    Catalytic activityi

    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

    Cofactori

    Binds 1 copper ion per dimer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801CopperBy similarity
    Metal bindingi84 – 841CopperBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ethylene binding Source: EnsemblPlants/Gramene
    3. metal ion binding Source: UniProtKB-KW
    4. phosphorelay response regulator activity Source: InterPro
    5. phosphorelay sensor kinase activity Source: InterPro
    6. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to iron ion Source: EnsemblPlants/Gramene
    2. cytokinin metabolic process Source: EnsemblPlants/Gramene
    3. defense response by callose deposition in cell wall Source: EnsemblPlants/Gramene
    4. defense response to bacterium Source: EnsemblPlants/Gramene
    5. detection of ethylene stimulus Source: EnsemblPlants/Gramene
    6. ethylene-activated signaling pathway Source: UniProtKB-KW
    7. hydrogen peroxide biosynthetic process Source: EnsemblPlants/Gramene
    8. regulation of seedling development Source: EnsemblPlants/Gramene
    9. regulation of stomatal movement Source: EnsemblPlants/Gramene
    10. response to abscisic acid Source: EnsemblPlants/Gramene
    11. response to auxin Source: EnsemblPlants/Gramene
    12. response to gibberellin Source: EnsemblPlants/Gramene
    13. response to heat Source: EnsemblPlants/Gramene
    14. response to insect Source: EnsemblPlants/Gramene
    15. response to molecule of bacterial origin Source: EnsemblPlants/Gramene
    16. response to salt stress Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase

    Keywords - Biological processi

    Ethylene signaling pathway, Two-component regulatory system

    Keywords - Ligandi

    ATP-binding, Copper, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethylene receptor 1 (EC:2.7.13.3)
    Short name:
    LeETR1
    Gene namesi
    Name:ETR1
    OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
    Taxonomic identifieri4081 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
    ProteomesiUP000004994: Chromosome 12

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 754754Ethylene receptor 1PRO_0000081416Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi18 – 18InterchainBy similarity
    Disulfide bondi20 – 20InterchainBy similarity
    Modified residuei367 – 3671Phosphohistidine; by autocatalysisPROSITE-ProRule annotation
    Modified residuei677 – 67714-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Activation probably requires a transfer of a phosphate group between a His in the transmitter domain and an Asp of the receiver domain.By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Expressioni

    Tissue specificityi

    Leaves, flowers and fruits.

    Developmental stagei

    Expressed at all stages.

    Inductioni

    Constitutively expressed and accumulation not affected by ethylene, silver ions or auxin.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    int106B6GVA22EBI-2407792,EBI-2407896

    Protein-protein interaction databases

    IntActiQ41342. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ41342.
    SMRiQ41342. Positions 624-753.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini173 – 321149GAFAdd
    BLAST
    Domaini364 – 601238Histidine kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini629 – 746118Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ethylene receptor family.Curated
    Contains 1 GAF domain.Curated
    Contains 1 histidine kinase domain.PROSITE-ProRule annotation
    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK14509.

    Family and domain databases

    Gene3Di1.10.287.130. 1 hit.
    3.30.450.40. 1 hit.
    3.30.565.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR003661. EnvZ-like_dim/P.
    IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003594. HATPase_ATP-bd.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR014525. Sig_transdc_His_kin_hyb_Et-sen.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view]
    PfamiPF01590. GAF. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view]
    PIRSFiPIRSF026389. Ethyln_sen_HK. 1 hit.
    PRINTSiPR00344. BCTRLSENSOR.
    SMARTiSM00065. GAF. 1 hit.
    SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    SM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF47384. SSF47384. 1 hit.
    SSF52172. SSF52172. 1 hit.
    SSF55781. SSF55781. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS50109. HIS_KIN. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q41342-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLLRMNRL LSSIVESCNC IIDPQLPADD LLMKYQYISD FFIALAYFSI    50
    PVELIYFVKK SAVFPYRWVL VQFGAFIVLC GATHLINLWT FNMHTRNVAI 100
    VMTTPKALTA LVSCITALML VHIIPDLLSV KTRELFLKKK AAQLDREMGI 150
    IRTQEETGRH VRMLTHEIRS TLDRHTILKT TLVELGRTLA LEECALWMPT 200
    RTGLELQLSY TLRHQNPVGL TVPIQLPVIN QVFGTNHVVK ISPNSPVARL 250
    RPAGKYMPGE VVAVRVPLLH LSNFQINDWP ELSTKRYALM VLMLPSDSAR 300
    QWHVHELELV EVVADQVAVA LSHAAILEES MRARDLLMEQ NVALDLARRE 350
    AEMAVRARND FLAVMNHEMR TPMHAIIALS SLLQETDLTP EQRLMVETIL 400
    KSSNLLATLI NDVLDLSRLE DGSLQLDIGT FNLHALFREV HSLIKPIASV 450
    KKLFVTLSLS SDLPEYVIGD EKRLMQILLN VVGNAVKFSK EGNVSISAFV 500
    AKSDSLRDPR APEFFAVPSE NHFYLRVQIK DTGIGITPQD IPNLFSKFTQ 550
    SQALATTNSG GTGLGLAICK RFVNLMEGHI WIESEGLGKG STAIFIIKLG 600
    IPGRANESKL PFVTKLPANH TQMSFQGLKV LVMDENGVSR MVTKGLLTHL 650
    GCDVTTVGSR DECLRVVTHE HKVVIMDVSM QGIDCYEVAV VIHERFGKRH 700
    GRPLIVALTG NTDRVTKENC MRVGMDGVIL KPVSVYKMRS VLSELLEHGV 750
    VLES 754
    Length:754
    Mass (Da):84,202
    Last modified:November 1, 1996 - v1
    Checksum:iD7443B6517781D0A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051P → A in AAC02213. (PubMed:9721682)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41103 mRNA. Translation: AAA85479.1.
    AF043084 mRNA. Translation: AAC02213.1.
    PIRiS71783.
    T52288.
    RefSeqiNP_001234149.1. NM_001247220.1.
    UniGeneiLes.3490.

    Genome annotation databases

    EnsemblPlantsiSolyc12g011330.2.1; Solyc12g011330.2.1; Solyc12g011330.2.
    GeneIDi606298.
    KEGGisly:606298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41103 mRNA. Translation: AAA85479.1 .
    AF043084 mRNA. Translation: AAC02213.1 .
    PIRi S71783.
    T52288.
    RefSeqi NP_001234149.1. NM_001247220.1.
    UniGenei Les.3490.

    3D structure databases

    ProteinModelPortali Q41342.
    SMRi Q41342. Positions 624-753.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q41342. 2 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi Solyc12g011330.2.1 ; Solyc12g011330.2.1 ; Solyc12g011330.2 .
    GeneIDi 606298.
    KEGGi sly:606298.

    Phylogenomic databases

    KOi K14509.

    Family and domain databases

    Gene3Di 1.10.287.130. 1 hit.
    3.30.450.40. 1 hit.
    3.30.565.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR003661. EnvZ-like_dim/P.
    IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003594. HATPase_ATP-bd.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR014525. Sig_transdc_His_kin_hyb_Et-sen.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view ]
    Pfami PF01590. GAF. 1 hit.
    PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF026389. Ethyln_sen_HK. 1 hit.
    PRINTSi PR00344. BCTRLSENSOR.
    SMARTi SM00065. GAF. 1 hit.
    SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47384. SSF47384. 1 hit.
    SSF52172. SSF52172. 1 hit.
    SSF55781. SSF55781. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS50109. HIS_KIN. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mRNA for an ETR1 homologue in tomato is constitutively expressed in vegetative and reproductive tissues."
      Zhou D., Kalaitzis P., Mattoo A.K., Tucker M.L.
      Plant Mol. Biol. 30:1331-1338(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Rutgers.
      Tissue: Abscission zone and Fruit.
    2. "Differential regulation of the tomato ETR gene family throughout plant development."
      Lashbrook C.C., Tieman D.M., Klee H.J.
      Plant J. 15:243-252(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Rutgers.
      Tissue: Root.

    Entry informationi

    Entry nameiETR1_SOLLC
    AccessioniPrimary (citable) accession number: Q41342
    Secondary accession number(s): O49186
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 2, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3