Reviewed, UniProtKB/Swiss-Prot Q41247 (AL7A1_BRANA)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase family 7 member A1
    EC=1.2.1.3
Alternative name(s):
    Antiquitin-1
    Brassica turgor-responsive/drought-induced gene 26 protein
      Short name=Btg-26

Gene names

Name:

BTG-26

Organism

Brassica napus (Rape)

Taxonomic identifier

3708 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Brassica

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH. UniProtKB P83402
Subunit structure	Homotetramer By similarity. UniProtKB P83402
Induction	By water stress, low temperature, heat shock, high salt and abscisic acid. Ref.1
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Stress response
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Non-traceable author statement. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 494	493	Aldehyde dehydrogenase family 7 member A1		PRO_0000056496
Regions
	Nucleotide binding	247 – 252	6	NAD By similarity UniProtKB Q56694
Sites
	Active site	269	1	Proton acceptor By similarity UniProtKB Q56694
	Active site	303	1	Nucleophile By similarity UniProtKB Q56694
	Site	168	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q41247-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 13ED0096563BAE13	FASTA	494	52,688
	10 20 30 40 50 60 MGSASKEYEF LSEIGLSSSH NLGNYVGGKW LGNGPLVSTL NPANNQVLPI AQVVEASLED 70 80 90 100 110 120 YEIGLKACEE AAKTWMQVPA PKRGDIVRQI GDALRSKLDY LGRLLSLEMG KILAEGIGEV 130 140 150 160 170 180 QEVIDMCDFA VGLSRQLNGS VIPSERPNHM MLEMWNPLGI VGVITAFNFP CAVLGWNACI 190 200 210 220 230 240 ALVCGNCVVW KGAPTTPLIT IAMTKLVAEV LEKNHLPGAI FTAMCGGAEI GEAIAKDTRI 250 260 270 280 290 300 PLVSFTGSSK VGLTVQQTVS ARSGKTLLEL SGNNAIIVMD DADIQLAARS VLFAAVGTAG 310 320 330 340 350 360 QRCTTCRRLL LHESVYDKVL EQLLTSYKQV KIGDPLEKGT LLGPLHTPES KKNFEKGIEV 370 380 390 400 410 420 IKSQGGKVLT GGKAVEGEGN FVEPTIIEIS SDAAVVKEEL FAPVLYALKF KTFEEAVAIN 430 440 450 460 470 480 NSVPQGLSSS IFTRSPDNIF KWIGPMGSDC GIVNVNIPTN GAEIGGAFGG EKATGGGREA 490 GSDSWKQYMR RSTW

References

[1]	"Molecular cloning and expression of a turgor-responsive gene in Brassica napus." Stroeher V.L., Boothe J.G., Good A.G. Plant Mol. Biol. 27:541-551(1995) [PubMed: 7894018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION. Strain: cv. Bridger. Tissue: Leaf.
[2]	"First purification of the antiquitin protein and demonstration of its enzymatic activity." Tang W.-K., Cheng C.H.K., Fong W.-P. FEBS Lett. 516:183-186(2002) [PubMed: 11959129] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-16.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S77096 Genomic DNA. Translation: AAB33843.1.
PIR	S53503.
3D structure databases
HSSP	HSSP built from PDB template 1O04 based on UniProtKB P05091.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.3. 393.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7A1_BRANA

Accession

Primary (citable) accession number: Q41247

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)