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Q41233

- ALLN2_ALLSA

UniProt

Q41233 - ALLN2_ALLSA

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Protein
Alliin lyase 2
Gene
N/A
Organism
Allium sativum (Garlic)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Able to cleave the C-S bond of sulfoxide derivatives of Cys to produce allicin, thus giving rise to all sulfur compounds which are responsible for most of the properties of garlic, such as the specific smell and flavor as well as the health benefits like blood lipid or blood pressure lowering.

Catalytic activityi

An S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate.

Cofactori

Pyridoxal phosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191Chloride By similarity
Binding sitei123 – 1231Chloride By similarity
Binding sitei125 – 1251Chloride By similarity

GO - Molecular functioni

  1. alliin lyase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Chloride, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13491.

Names & Taxonomyi

Protein namesi
Recommended name:
Alliin lyase 2 (EC:4.4.1.4)
Short name:
Alliinase-2
Alternative name(s):
Cysteine sulphoxide lyase 2
OrganismiAllium sativum (Garlic)
Taxonomic identifieri4682 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesAmaryllidaceaeAllioideaeAllieaeAllium

Subcellular locationi

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

Pathology & Biotechi

Protein family/group databases

Allergomei843. All s Alliin lyase.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Propeptidei16 – 2510 By similarity
PRO_0000020679
Chaini26 – 473448Alliin lyase 2
PRO_0000020680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi45 ↔ 64 By similarity
Disulfide bondi66 ↔ 75 By similarity
Disulfide bondi69 ↔ 82 By similarity
Glycosylationi171 – 1711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Modified residuei276 – 2761N6-(pyridoxal phosphate)lysine By similarity
Glycosylationi353 – 3531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi393 ↔ 401 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

High expression in bulbs, lower expression in leaves, and no expression in roots.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ41233.
SMRiQ41233. Positions 26-452.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 8447EGF-like; atypical
Add
BLAST

Domaini

The 6 Cys residues of the EGF-like domain are arranged in a disulfide pattern different from the one found in the canonical EGFs. The function of this domain is unclear. It may be a binding site for other proteins or the docking site for a putative alliinase receptor By similarity.

Sequence similaritiesi

Belongs to the alliinase family.
Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal

Family and domain databases

Gene3Di2.10.25.30. 1 hit.
3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR006948. Alliinase_C.
IPR006947. EGF_alliinase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF04864. Alliinase_C. 1 hit.
PF04863. EGF_alliinase. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q41233-1 [UniParc]FASTAAdd to Basket

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MICLVILTCI IMSNSFVNNN NMVQAKMTWT MKAAEEAEAV ANINCSEHGR    50
AFLDGIISEG SPKCECNTCY TGPDCSEKIQ GCSADVASGD GLFLEEYWKQ 100
HKEASAVLVS PWHRMSYFFN PVSNFISFEL EKTIKELHEV VGNAAAKDRY 150
IVFGVGVTQL IHGLVISLSP NMTATPDAPE SKVVAHAPFY PVFREQTKYF 200
DKKGYVWAGN AANYVNVSNP EQYIEMVTSP NNPEGLLRHA VIKGCKSIYD 250
MVYYWPHYTP IKYKADEDIL LFTMSKFTGH SGSRFGWALI KDESVYNNLL 300
NYMTKNTEGT PRETQLRSLK VLKEIVAMVK TQKGTMRDLN TFGFKKLRER 350
WVNITALLDQ SDRFSYQELP QSEYCNYFRR MRPPSPSYAW VNCEWEEDKD 400
CYQTFQNGRI NTQSGVGFEA SSRYVRLSLI KTQDDFDQLM YYLKDMVKAK 450
RKTPLIKQLF TDETETASRR PFI 473
Length:473
Mass (Da):54,183
Last modified:November 1, 1996 - v1
Checksum:i19F08669BA95A047
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S73324 mRNA. Translation: AAB32477.1.

Cross-referencesi

Web resourcesi

Protein Spotlight

What's that smell? - Issue 39 of October 2003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S73324 mRNA. Translation: AAB32477.1 .

3D structure databases

ProteinModelPortali Q41233.
SMRi Q41233. Positions 26-452.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 843. All s Alliin lyase.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-13491.

Family and domain databases

Gene3Di 2.10.25.30. 1 hit.
3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR006948. Alliinase_C.
IPR006947. EGF_alliinase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF04864. Alliinase_C. 1 hit.
PF04863. EGF_alliinase. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Alliin lyase (Alliinase) from garlic (Allium sativum). Biochemical characterization and cDNA cloning."
    Rabinkov A., Zhu X.Z., Grafi G., Galili G., Mirelman D.
    Appl. Biochem. Biotechnol. 48:149-171(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Tissue: Bulb.

Entry informationi

Entry nameiALLN2_ALLSA
AccessioniPrimary (citable) accession number: Q41233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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