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Protein

Leghemoglobin reductase

Gene

FLBR

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduces ferric leghemoglobin (Lb) to ferrous Lb.1 Publication

Catalytic activityi

NAD(P)H + 2 ferrileghemoglobin = NAD(P)+ + 2 ferroleghemoglobin.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84FADBy similarity1
Binding sitei148FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei237NADBy similarity1
Binding sitei271NAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei306NAD; via amide nitrogenBy similarity1
Binding sitei347FADBy similarity1
Active sitei479Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 75FADBy similarity10
Nucleotide bindingi177 – 179FADBy similarity3
Nucleotide bindingi214 – 221NADBy similarity8
Nucleotide bindingi353 – 356FADBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Leghemoglobin reductase (EC:1.6.2.6)
Alternative name(s):
Ferric leghemoglobin reductase
Short name:
FLbR
Gene namesi
Name:FLBR
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30Mitochondrion1 PublicationAdd BLAST30
ChainiPRO_000042413731 – 523Leghemoglobin reductaseAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 80Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

ProMEXiQ41219

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher level in leaf and nodules.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ41219
SMRiQ41219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

KOiK00382

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01350 lipoamide_DH, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q41219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMANLARRK GYAVVLSSRS SLCLTRWRGF ASGSDENDVV VIGGGPGGYV
60 70 80 90 100
AAIKAAQLGL KTTCIEKRGT LGGTCLNVGC IPSKALLHSS HMYHEAKHAF
110 120 130 140 150
ANHGVKFSSV EVALPAMMGQ KDKAVSNLTQ GIDGLFQKNK VTYVKGYGKL
160 170 180 190 200
VSPSEISVDT TEGENTVVKG KHIIIATGSD VKSLPGVTID EKKIVSSTGA
210 220 230 240 250
LALSEIPKKL VVIGAGYIGL EMGSVWGRIG SEVTVVEFAS EIVPTMDADI
260 270 280 290 300
RKQFQRSLEK QGMKFKLKTK VVGVDTSGDG VKLTVEPSAG GEQTIIEADV
310 320 330 340 350
VLVSAGRTPF TSGLNLDKIG VETDKLGRIL VNERFSTNVS GVYAIGDVIP
360 370 380 390 400
GPMLAHKAEE DGVACVEYLT GKVGHVDYDK VPGVVYTNPE VASVGKTEEQ
410 420 430 440 450
VKETGVEYRV GKFPFLANSR AKAIDNAEGL VKIIAEKETD KILGVHIMAP
460 470 480 490 500
NAGELIHEAA IALQYDASSE DIARVCHAHP TMSEAVKEAA MATYDKPHSH
510 520
LKSWLLLSSL VFIFVQEFTM TWR
Length:523
Mass (Da):55,804
Last modified:November 1, 1996 - v1
Checksum:i4281E1412358673F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70187 mRNA Translation: AAB30526.1
PIRiT08854
RefSeqiNP_001238628.1, NM_001251699.1
UniGeneiGma.37081

Genome annotation databases

GeneIDi547832
KEGGigmx:547832

Similar proteinsi

Entry informationi

Entry nameiLEGRE_SOYBN
AccessioniPrimary (citable) accession number: Q41219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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