Reviewed, UniProtKB/Swiss-Prot Q41141 (PFPB_RICCO)

Names and origin

Protein names

Recommended name:
    Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta
      Short name=PFP
    EC=2.7.1.90
Alternative name(s):
    6-phosphofructokinase, pyrophosphate dependent
    Pyrophosphate-dependent 6-phosphofructose-1-kinase
    PPi-PFK

Gene names

Name:

PFP-BETA

Organism

Ricinus communis (Castor bean)

Taxonomic identifier

3988 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Malpighiales › Euphorbiaceae › Acalyphoideae › Acalypheae › Ricinus

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Diphosphate + D-fructose 6-phosphate = phosphate + D-fructose 1,6-bisphosphate.
Enzyme regulation	Fru-2,6-P is an activator of the plant enzyme.
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Miscellaneous	The active site might be on the beta subunit.
Sequence similarities	Belongs to the pyrophosphate-dependent phosphofructokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Allosteric enzyme
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphofructokinase activity Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW diphosphate-fructose-6-phosphate 1-phosphotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta		PRO_0000112049
Sites
	Active site	214	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q41141-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E4DC19ADB6317A8E	FASTA	552	60,114
	10 20 30 40 50 60 MATPNSGRAA SVYSEVQSSR IEHVLPLPSV LNHPFKIVQG PPSSAAGNPD EIAKLFPNLF 70 80 90 100 110 120 GQPSAMLVPD VADSLDSNQQ LKIGLVLSGG QAPGGHNVIS GIFDYLQDRA KGSILYGFRG 130 140 150 160 170 180 GPAGIMKCNY VQLTADYIHP YRNQGGFDMI CSGRDKIETP EQFKQAEETA GKLDLNGLVV 190 200 210 220 230 240 IGGDDSNTNA CLLAENFRSK NLKTRVIGCP KTIDGDLKCK EVPTSFGFDT ACKIYSEMIG 250 260 270 280 290 300 NVMIDARSTG KYYHFVRLMG RAASHITLEC ALQTHPNITI IGEEVAAKKL ALKDVTDYIV 310 320 330 340 350 360 DVICKRADLG YNYGVILIPE GLIDFIPEVQ NLIAELNEIL AHDVVDEGGL WKKKLTSQSL 370 380 390 400 410 420 QLFEFLPVAI QEQLMLERDP HGNVQVAKIE TEKMLIQMVE TELEKRKQQG TYKAHFKGQS 430 440 450 460 470 480 HFFGYEGRCG LPTNFDSTYC YALGYAAGAL LHSGKTGLIS SVGNLGAPVA EWTVGGTALT 490 500 510 520 530 540 SLMDVERRHG KFKPVIKKAM VELEGAPFKK FASLREEWAL KNRYVSPGPI QFMGPGSDAA 550 SHTLLLELGS VA

References

[1]	"Structure of the genes encoding the alpha- and beta-subunits of castor pyrophosphate-dependent phosphofructokinase." Todd J.F., Blakeley S.D., Dennis D.T. Gene 152:181-186(1995) [PubMed: 7835697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z32850 Genomic DNA. Translation: CAA83683.1.
PIR	T10107.
3D structure databases
HSSP	HSSP built from PDB template 1KZH based on UniProtKB P70826.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.1.90. 816.
Family and domain databases
InterPro	IPR011183. PfpB_PPi_PFK. IPR000023. Phosphofructokinase. [Graphical view]
Pfam	PF00365. PFK. 1 hit. [Graphical view]
PIRSF	PIRSF005677. PPi_PFK_PfpB. 1 hit.
PRINTS	PR00476. PHFRCTKINASE.
ProDom	PD000707. Ppfruckinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR02477. PFKA_PPi. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PFPB_RICCO

Accession

Primary (citable) accession number: Q41141

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)