Q41140 (PFPA_RICCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha
Short name=PFP
EC=2.7.1.90

Alternative name(s):
6-phosphofructokinase, pyrophosphate dependent
PPi-PFK
Pyrophosphate-dependent 6-phosphofructose-1-kinase

Gene names

Name:

PFP-ALPHA

Organism

Ricinus communis (Castor bean)

Taxonomic identifier

3988 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Euphorbiaceae › Acalyphoideae › Acalypheae › Ricinus

Protein attributes

Sequence length	617 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The alpha subunit may be involved in the regulation of PFP by Fru-2,6-P By similarity.
Catalytic activity	Diphosphate + D-fructose 6-phosphate = phosphate + D-fructose 1,6-bisphosphate.
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Miscellaneous	The active site might be on the beta subunit.
Sequence similarities	Belongs to the pyrophosphate-dependent phosphofructokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Allosteric enzyme
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphofructokinase activity Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW diphosphate-fructose-6-phosphate 1-phosphotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 617	617	Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha		PRO_0000112047

Sequences

	Sequence		Length	Mass (Da)
	Q41140 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1C9B2A0AF11FF3F0	FASTA	617	67,361
	10 20 30 40 50 60 MDSDFGIPRE LSDLQKLRSL YKPELPPCLQ GTTVRVELGD GTTACSEAGA HTISRSFPHT 70 80 90 100 110 120 YGQPLAHFLR ATAKVADAHI ISEHPAMRVG VVFCGRQSPG GHNVVWGLHN ALKIHNPNST 130 140 150 160 170 180 LLGFLGGSEG LFAQKTLEVT DDILSTYKNQ GGYDLLGRTK DQIRTTEQVH AALTTCKNLK 190 200 210 220 230 240 LDGLVIIGGV TSNTDAAQLA ETFAEAKCPT KVVGVPVTLN GDLKNQFVET NVGFDTICKV 250 260 270 280 290 300 NSQLISNVCT DALSAEKYYY FIRLMGRKAS HVALECTLQS HPNMVILGEE VAASKLTLFD 310 320 330 340 350 360 LTKQVCDAVQ ARAEQDKYHG VILLPEGLIE SIPEVYALLK EIHGLLRQGV SPNNISSQLS 370 380 390 400 410 420 PWASALFEFL PPFIKKQLLL YPESDDSAQL SQIETEKLLA HLVEAEMNKR LKEGTYKGKK 430 440 450 460 470 480 FNAICHFFGY QARGSLPSKF DCDYAYVLGH ICYHVLAAGL NGYMATATNL KNPVNKWRCG 490 500 510 520 530 540 AAPIAAMMTV KRWAQNPGAT SIGKPAIHPA AVDLKGKAYE LLRLNAVKFL MDDLYRNPGP 550 560 570 580 590 600 LQFEGPGADA KPITLCVEDQ DYMGRIKKLQ EYLDKVRTIV KPGCSQEVLK AALSVMASVT 610 DVLLTMSSTS LDGQKPL

References

[1]	"Structure of the genes encoding the alpha- and beta-subunits of castor pyrophosphate-dependent phosphofructokinase." Todd J.F., Blakeley S.D., Dennis D.T. Gene 152:181-186(1995) [PubMed: 7835697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z32849 Genomic DNA. Translation: CAA83682.1.
PIR	T10102.
3D structure databases
ProteinModelPortal	Q41140.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011183. PfpB_PPi_PFK. IPR000023. Phosphofructokinase_dom. IPR013981. PPi-dep_PFK_a-hlx. [Graphical view]
Gene3D	G3DSA:1.10.10.480. PPi-dep_PFK_a-hlx. 1 hit.
Pfam	PF00365. PFK. 1 hit. [Graphical view]
PIRSF	PIRSF005677. PPi_PFK_PfpB. 1 hit.
SUPFAM	SSF53784. Ppfruckinase. 1 hit.
TIGRFAMs	TIGR02477. PFKA_PPi. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PFPA_RICCO

Accession

Primary (citable) accession number: Q41140

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	September 21, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program