Q41107 (INO1_PHAVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Inositol-3-phosphate synthase Short name=MIP synthase EC=5.5.1.4 Alternative name(s): Myo-inositol-1-phosphate synthase Short name=IPS Short name=MI-1-P synthase
Organism	Phaseolus vulgaris (Kidney bean) (French bean)
Taxonomic identifier	3885 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Phaseolus

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
Cofactor	NAD By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the myo-inositol-1-phosphate synthase family.

Ontologies

Keywords
Biological process	Inositol biosynthesis Phospholipid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	inositol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inositol-3-phosphate synthase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Inositol-3-phosphate synthase		PRO_0000195196

Sequences

	Sequence		Length	Mass (Da)
	Q41107 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 76A9558088CA58EF	FASTA	511	56,527
	10 20 30 40 50 60 MFIESFKVES PNVKYTENEI HSVYDYETTE VVHEKTVNGT YQWIVKPKTV KYDFKTDIRV 70 80 90 100 110 120 PKLGVMLVGL GGNNGSTLTA GVIANKEGIS WATKDKVQQA NYFGSLTQAS SIRVGSFNGE 130 140 150 160 170 180 EIYAPFKSLL PMVNPDDVVF GGWDISDMNL ADAMARARVL DIDLQKQLRP YMENIVPLPG 190 200 210 220 230 240 IFDPDFIAAN QGSRANHVIK GTKKEQVDHI IKDMREFKEK NKVDKVVVLW TANTERYSNE 250 260 270 280 290 300 VVGMNDTMED LMESVDRDEA EISPSTLYAI ACVLEGIPFI NGSPQHTFVP GLIDMAIRNN 310 320 330 340 350 360 VLIGGDDFKS GQTKMKSVLG DFLVGAGIKP TSIVSYNHLG NNDGMNLSAP QTFRSKEISK 370 380 390 400 410 420 SNVVDDMVAS NGILFEPGEH PDHVVVIKYV PYVADSKRAM DEYTSEIFMG GKNTIVMHNT 430 440 450 460 470 480 CEDSLLAAPI ILDLVLLAEL STRIQFKSEG EGKFHSFHPV ATILSYLTKA PLVPPGTPVI 490 500 510 NALSKQRAML ENIMRACVGL APENNMIMEF K

References

[1]	"An isoform of 1L-myo-Inositol 1-phosphate synthase (EC 5.5.1.4) from Phaseolus vulgaris." Wang X., Johnson M.D. Plant Gene Register PGR95-121 Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Taylor's horticultural. Tissue: Root.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U38920 mRNA. Translation: AAA91164.1.
PIR	T10964.
3D structure databases
ProteinModelPortal	Q41107.
SMR	Q41107. Positions 4-511.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002587. Myo-inos-1-P_Synthase. IPR013021. Myo-inos-1-P_Synthase_GAPDH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
PANTHER	PTHR11510. Inos-1-P_synth. 1 hit.
Pfam	PF01658. Inos-1-P_synth. 1 hit. PF07994. NAD_binding_5. 1 hit. [Graphical view]
PIRSF	PIRSF015578. Myoinos-ppht_syn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

INO1_PHAVU

Accession

Primary (citable) accession number: Q41107

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program