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Q40963

- MPA5B_PHLPR

UniProt

Q40963 - MPA5B_PHLPR

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Protein
Pollen allergen Phl p 5b
Gene
N/A
Organism
Phleum pratense (Common timothy)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Has ribonuclease activity. May be involved in host-pathogen interactions.

GO - Biological processi

  1. type I hypersensitivity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pollen allergen Phl p 5b
Alternative name(s):
Allergen Phl p Vb
Allergen: Phl p 5b
OrganismiPhleum pratense (Common timothy)
Taxonomic identifieri15957 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaePoeaeAlopecurinaePhleum

Organism-specific databases

GrameneiQ40963.

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Causes grass pollen allergy.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei558. Phl p 5.
567. Phl p 5.0201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 19›19 Reviewed prediction
Add
BLAST
Chaini20 – 284265Pollen allergen Phl p 5b
PRO_0000021746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi205 – 205Interchain1 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi152 – 1554
Helixi158 – 17316
Helixi177 – 1793
Helixi180 – 19516
Turni196 – 1983
Helixi203 – 2053
Helixi207 – 21812
Turni219 – 2224
Helixi225 – 2273
Helixi228 – 25023

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L3PX-ray1.98A150-251[»]
ProteinModelPortaliQ40963.
SMRiQ40963. Positions 39-138, 150-251.

Miscellaneous databases

EvolutionaryTraceiQ40963.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.120.320. 2 hits.
InterProiIPR001778. POA_allergen.
IPR002914. POA_allergen_N.
[Graphical view]
PfamiPF01620. Pollen_allerg_2. 2 hits.
[Graphical view]
PRINTSiPR00833. POAALLERGEN.
SUPFAMiSSF81736. SSF81736. 2 hits.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q40963-1 [UniParc]FASTAAdd to Basket

« Hide

AAAAVPRRGP RGGPGRSYTA DAGYAPATPA AAGAAAGKAT TEEQKLIEDI    50
NVGFKAAVAA AASVPAADKF KTFEAAFTSS SKAAAAKAPG LVPKLDAAYS 100
VAYKAAVGAT PEAKFDSFVA SLTEALRVIA GALEVHAVKP VTEEPGMAKI 150
PAGELQIIDK IDAAFKVAAT AAATAPADDK FTVFEAAFNK AIKESTGGAY 200
DTYKCIPSLE AAVKQAYAAT VAAAPQVKYA VFEAALTKAI TAMSEVQKVS 250
QPATGAATVA AGAATTAAGA ASGAATVAAG GYKV 284
Length:284
Mass (Da):28,002
Last modified:July 15, 1998 - v2
Checksum:iE949FB3E0985295E
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z27083 mRNA. Translation: CAA81609.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z27083 mRNA. Translation: CAA81609.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1L3P X-ray 1.98 A 150-251 [» ]
ProteinModelPortali Q40963.
SMRi Q40963. Positions 39-138, 150-251.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 558. Phl p 5.
567. Phl p 5.0201.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q40963.

Miscellaneous databases

EvolutionaryTracei Q40963.

Family and domain databases

Gene3Di 1.20.120.320. 2 hits.
InterProi IPR001778. POA_allergen.
IPR002914. POA_allergen_N.
[Graphical view ]
Pfami PF01620. Pollen_allerg_2. 2 hits.
[Graphical view ]
PRINTSi PR00833. POAALLERGEN.
SUPFAMi SSF81736. SSF81736. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Major allergen Phl p Vb in timothy grass is a novel pollen RNase."
    Bufe A., Schramm G., Keown M.B., Schlaak M., Becker W.M.
    FEBS Lett. 363:6-12(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Agrostideae.
    Tissue: Pollen.
  2. Bufe A.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Structure of the functional domain of the major grass-pollen allergen Phlp 5b."
    Rajashankar K., Bufe A., Weber W., Eschenburg S., Lindner B., Betzel C.
    Acta Crystallogr. D 58:1175-1181(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 150-251, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiMPA5B_PHLPR
AccessioniPrimary (citable) accession number: Q40963
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: October 16, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi