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Protein

Pollen allergen Phl p 5b

Gene
N/A
Organism
Phleum pratense (Common timothy)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has ribonuclease activity. May be involved in host-pathogen interactions.

GO - Molecular functioni

  • ribonuclease activity Source: CACAO
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pollen allergen Phl p 5b
Alternative name(s):
Allergen Phl p Vb
Allergen: Phl p 5b
OrganismiPhleum pratense (Common timothy)
Taxonomic identifieri15957 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaePoodaePoeaePoeae Chloroplast Group 2 (Poeae type)PoinaePhleum

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Causes grass pollen allergy.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei558. Phl p 5.
567. Phl p 5.0201.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 19Sequence analysisAdd BLAST›19
ChainiPRO_000002174620 – 284Pollen allergen Phl p 5bAdd BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi205Interchain1 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi152 – 155Combined sources4
Helixi158 – 173Combined sources16
Helixi177 – 179Combined sources3
Helixi180 – 195Combined sources16
Turni196 – 198Combined sources3
Helixi203 – 205Combined sources3
Helixi207 – 218Combined sources12
Turni219 – 222Combined sources4
Helixi225 – 227Combined sources3
Helixi228 – 250Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L3PX-ray1.98A150-251[»]
ProteinModelPortaliQ40963.
SMRiQ40963.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ40963.

Family & Domainsi

Sequence similaritiesi

Belongs to the Poa p IX/Phl p VI allergen family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.120.320. 2 hits.
InterProiIPR002914. Poa_pIX/Phl_pVI.
[Graphical view]
PfamiPF01620. Pollen_allerg_2. 2 hits.
[Graphical view]
SUPFAMiSSF81736. SSF81736. 2 hits.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q40963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AAAAVPRRGP RGGPGRSYTA DAGYAPATPA AAGAAAGKAT TEEQKLIEDI
60 70 80 90 100
NVGFKAAVAA AASVPAADKF KTFEAAFTSS SKAAAAKAPG LVPKLDAAYS
110 120 130 140 150
VAYKAAVGAT PEAKFDSFVA SLTEALRVIA GALEVHAVKP VTEEPGMAKI
160 170 180 190 200
PAGELQIIDK IDAAFKVAAT AAATAPADDK FTVFEAAFNK AIKESTGGAY
210 220 230 240 250
DTYKCIPSLE AAVKQAYAAT VAAAPQVKYA VFEAALTKAI TAMSEVQKVS
260 270 280
QPATGAATVA AGAATTAAGA ASGAATVAAG GYKV
Length:284
Mass (Da):28,002
Last modified:July 15, 1998 - v2
Checksum:iE949FB3E0985295E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27083 mRNA. Translation: CAA81609.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27083 mRNA. Translation: CAA81609.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L3PX-ray1.98A150-251[»]
ProteinModelPortaliQ40963.
SMRiQ40963.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei558. Phl p 5.
567. Phl p 5.0201.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ40963.

Family and domain databases

Gene3Di1.20.120.320. 2 hits.
InterProiIPR002914. Poa_pIX/Phl_pVI.
[Graphical view]
PfamiPF01620. Pollen_allerg_2. 2 hits.
[Graphical view]
SUPFAMiSSF81736. SSF81736. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMPA5B_PHLPR
AccessioniPrimary (citable) accession number: Q40963
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.