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Q40963 (MPA5B_PHLPR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pollen allergen Phl p 5b
Alternative name(s):
Allergen Phl p Vb
Allergen=Phl p 5b
OrganismPhleum pratense (Common timothy)
Taxonomic identifier15957 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaePoeaeAlopecurinaePhleum

Protein attributes

Sequence length284 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has ribonuclease activity. May be involved in host-pathogen interactions.

Subunit structure

Homodimer; disulfide-linked. Ref.3

Allergenic properties

Causes an allergic reaction in human. Causes grass pollen allergy.

Sequence similarities

Belongs to the Poa p IX/Phl p VI allergen family.

Ontologies

Keywords
   DiseaseAllergen
   DomainSignal
   PTMDisulfide bond
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processtype I hypersensitivity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – 19›19 Potential
Chain20 – 284265Pollen allergen Phl p 5b
PRO_0000021746

Amino acid modifications

Disulfide bond205Interchain Ref.3

Experimental info

Non-terminal residue11

Secondary structure

................. 284
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q40963 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: E949FB3E0985295E

FASTA28428,002
        10         20         30         40         50         60 
AAAAVPRRGP RGGPGRSYTA DAGYAPATPA AAGAAAGKAT TEEQKLIEDI NVGFKAAVAA 

        70         80         90        100        110        120 
AASVPAADKF KTFEAAFTSS SKAAAAKAPG LVPKLDAAYS VAYKAAVGAT PEAKFDSFVA 

       130        140        150        160        170        180 
SLTEALRVIA GALEVHAVKP VTEEPGMAKI PAGELQIIDK IDAAFKVAAT AAATAPADDK 

       190        200        210        220        230        240 
FTVFEAAFNK AIKESTGGAY DTYKCIPSLE AAVKQAYAAT VAAAPQVKYA VFEAALTKAI 

       250        260        270        280 
TAMSEVQKVS QPATGAATVA AGAATTAAGA ASGAATVAAG GYKV 

« Hide

References

[1]"Major allergen Phl p Vb in timothy grass is a novel pollen RNase."
Bufe A., Schramm G., Keown M.B., Schlaak M., Becker W.M.
FEBS Lett. 363:6-12(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Agrostideae.
Tissue: Pollen.
[2]Bufe A.
Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Structure of the functional domain of the major grass-pollen allergen Phlp 5b."
Rajashankar K., Bufe A., Weber W., Eschenburg S., Lindner B., Betzel C.
Acta Crystallogr. D 58:1175-1181(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 150-251, SUBUNIT, DISULFIDE BOND.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z27083 mRNA. Translation: CAA81609.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1L3PX-ray1.98A150-251[»]
ProteinModelPortalQ40963.
SMRQ40963. Positions 39-138, 150-251.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome558. Phl p 5.
567. Phl p 5.0201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneQ40963.

Family and domain databases

Gene3D1.20.120.320. 2 hits.
InterProIPR001778. POA_allergen.
IPR002914. POA_allergen_N.
[Graphical view]
PfamPF01620. Pollen_allerg_2. 2 hits.
[Graphical view]
PRINTSPR00833. POAALLERGEN.
SUPFAMSSF81736. SSF81736. 2 hits.
ProtoNetSearch...

Other

EvolutionaryTraceQ40963.

Entry information

Entry nameMPA5B_PHLPR
AccessionPrimary (citable) accession number: Q40963
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: October 16, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Allergens

Nomenclature of allergens and list of entries