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Q40963

- MPA5B_PHLPR

UniProt

Q40963 - MPA5B_PHLPR

Protein

Pollen allergen Phl p 5b

Gene
N/A
Organism
Phleum pratense (Common timothy)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Has ribonuclease activity. May be involved in host-pathogen interactions.

    GO - Biological processi

    1. type I hypersensitivity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pollen allergen Phl p 5b
    Alternative name(s):
    Allergen Phl p Vb
    Allergen: Phl p 5b
    OrganismiPhleum pratense (Common timothy)
    Taxonomic identifieri15957 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaePoeaeAlopecurinaePhleum

    Organism-specific databases

    GrameneiQ40963.

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Causes grass pollen allergy.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei558. Phl p 5.
    567. Phl p 5.0201.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei‹1 – 19›19Sequence AnalysisAdd
    BLAST
    Chaini20 – 284265Pollen allergen Phl p 5bPRO_0000021746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi205 – 205Interchain1 Publication

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    Structurei

    Secondary structure

    1
    284
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi152 – 1554
    Helixi158 – 17316
    Helixi177 – 1793
    Helixi180 – 19516
    Turni196 – 1983
    Helixi203 – 2053
    Helixi207 – 21812
    Turni219 – 2224
    Helixi225 – 2273
    Helixi228 – 25023

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1L3PX-ray1.98A150-251[»]
    ProteinModelPortaliQ40963.
    SMRiQ40963. Positions 39-138, 150-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ40963.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Poa p IX/Phl p VI allergen family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.20.120.320. 2 hits.
    InterProiIPR001778. POA_allergen.
    IPR002914. POA_allergen_N.
    [Graphical view]
    PfamiPF01620. Pollen_allerg_2. 2 hits.
    [Graphical view]
    PRINTSiPR00833. POAALLERGEN.
    SUPFAMiSSF81736. SSF81736. 2 hits.

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q40963-1 [UniParc]FASTAAdd to Basket

    « Hide

    AAAAVPRRGP RGGPGRSYTA DAGYAPATPA AAGAAAGKAT TEEQKLIEDI    50
    NVGFKAAVAA AASVPAADKF KTFEAAFTSS SKAAAAKAPG LVPKLDAAYS 100
    VAYKAAVGAT PEAKFDSFVA SLTEALRVIA GALEVHAVKP VTEEPGMAKI 150
    PAGELQIIDK IDAAFKVAAT AAATAPADDK FTVFEAAFNK AIKESTGGAY 200
    DTYKCIPSLE AAVKQAYAAT VAAAPQVKYA VFEAALTKAI TAMSEVQKVS 250
    QPATGAATVA AGAATTAAGA ASGAATVAAG GYKV 284
    Length:284
    Mass (Da):28,002
    Last modified:July 15, 1998 - v2
    Checksum:iE949FB3E0985295E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z27083 mRNA. Translation: CAA81609.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z27083 mRNA. Translation: CAA81609.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1L3P X-ray 1.98 A 150-251 [» ]
    ProteinModelPortali Q40963.
    SMRi Q40963. Positions 39-138, 150-251.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 558. Phl p 5.
    567. Phl p 5.0201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q40963.

    Miscellaneous databases

    EvolutionaryTracei Q40963.

    Family and domain databases

    Gene3Di 1.20.120.320. 2 hits.
    InterProi IPR001778. POA_allergen.
    IPR002914. POA_allergen_N.
    [Graphical view ]
    Pfami PF01620. Pollen_allerg_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00833. POAALLERGEN.
    SUPFAMi SSF81736. SSF81736. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Major allergen Phl p Vb in timothy grass is a novel pollen RNase."
      Bufe A., Schramm G., Keown M.B., Schlaak M., Becker W.M.
      FEBS Lett. 363:6-12(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Agrostideae.
      Tissue: Pollen.
    2. Bufe A.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Structure of the functional domain of the major grass-pollen allergen Phlp 5b."
      Rajashankar K., Bufe A., Weber W., Eschenburg S., Lindner B., Betzel C.
      Acta Crystallogr. D 58:1175-1181(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 150-251, SUBUNIT, DISULFIDE BOND.

    Entry informationi

    Entry nameiMPA5B_PHLPR
    AccessioniPrimary (citable) accession number: Q40963
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3