Q40905 (NLT13_PARJU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Probable non-specific lipid-transfer protein 1 Short name=LTP Alternative name(s): Allergen Par j I Major pollen allergen Par j 1.0201 Protein P1 Allergen=Par j 1.0201
Organism	Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa)
Taxonomic identifier	33127 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Urticaceae › Parietaria

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE and induces histamine release from basophils of Pj-pollen-allergic subjects.
Sequence similarities	Belongs to the plant LTP family.

Ontologies

Keywords
Biological process	Transport
Disease	Allergen
Domain	Signal
Ligand	Lipid-binding
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	lipid transport Inferred from electronic annotation. Source: InterPro
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 36	36	Potential
	Chain	37 – 138	102	Probable non-specific lipid-transfer protein 1		PRO_0000018397
Amino acid modifications
	Disulfide bond	40 ↔ 88		By similarity
	Disulfide bond	50 ↔ 65		By similarity
	Disulfide bond	66 ↔ 111		By similarity
	Disulfide bond	86 ↔ 127		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q40905 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A4E66230FEC0B6EE	FASTA	138	14,414
	10 20 30 40 50 60 MRTVSARSSV ALVVIVAAVL VWTSSASVAP APAPGSEETC GTVVGALMPC LPFVQGKEKE 70 80 90 100 110 120 PSKGCCSGAK RLDGETKTGP QRVHACECIQ TAMKTYSDID GKLVSEVPKH CGIVDSKLPP 130 IDVNMDCKTL GVLHYKGN

References

[1]

"Isolation and characterization of two cDNA clones coding for isoforms of the Parietaria judaica major allergen Par j 1.0101." Duro G., Colombo P., Costa M.A., Izzo V., Porcasi R., di Fiore R., Locorotondo G., Cocchiara R., Geraci D. Int. Arch. Allergy Immunol. 112:348-355(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pollen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85012 mRNA. Translation: CAA59370.1.
PIR	S52933.
3D structure databases
ProteinModelPortal	Q40905.
ModBase	Search...
Protein family/group databases
Allergome	503. Par j 1. 506. Par j 1.0201.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016140. Bifunc_inhib/LTP/seed_store. IPR000528. Plant_LTP. [Graphical view]
Pfam	PF00234. Tryp_alpha_amyl. 1 hit. [Graphical view]
PRINTS	PR00382. LIPIDTRNSFER.
SMART	SM00499. AAI. 1 hit. [Graphical view]
SUPFAM	SSF47699. Bifunc_inhib/LTP/seed_store. 1 hit.
PROSITE	PS00597. PLANT_LTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NLT13_PARJU

Accession

Primary (citable) accession number: Q40905

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program