ALDP

Functionⁱ

Plays a key role in glycolysis and gluconeogenesis.By similarity

Catalytic activityⁱ

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.By similarity

Pathwayⁱ: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.Curated
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	72	SubstrateBy similarity	1
Active siteⁱ	215	Proton acceptorBy similarity	1
Active siteⁱ	257	Schiff-base intermediate with dihydroxyacetone-PBy similarity	1
Binding siteⁱ	329	SubstrateBy similarity	1
Siteⁱ	388	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity	1

GO - Molecular functionⁱ

fructose-bisphosphate aldolase activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 21782461

Complete GO annotation...

GO - Biological processⁱ

gluconeogenesis
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 21782461
glycolytic process
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 21782461

Complete GO annotation...

Keywordsⁱ

Molecular function	Lyase
Biological process	Glycolysis
Ligand	Schiff base

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00183.

UniPathwayⁱ

UPA00109; UER00183.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fructose-bisphosphate aldolase, chloroplasticCurated (EC:4.1.2.13Curated) Alternative name(s): Chloroplastic aldolase1 Publication Short name: AldP1 Publication
Gene namesⁱ	Name:ALDPCurated Ordered Locus Names:Os11g0171300Imported, LOC_Os11g07020Imported ORF Names:OsJ_33121Imported
Organismⁱ	Oryza sativa subsp. japonica (Rice)
Taxonomic identifierⁱ	39947 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › Liliopsida › Petrosaviidae › commelinids › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
Proteomesⁱ	UP000059680 Componentⁱ: Chromosome 11

Subcellular locationⁱ

Plastid › chloroplast › plastoglobule
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:Q9SJU4 (ALFP1_ARATH)

GO - Cellular componentⁱ

cytoplasm
Source: Gramene
Inferred from sequence or structural similarityⁱ
- 8163192
plastoglobule Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Chloroplast, Plastid

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 38	Chloroplast1 PublicationAdd BLAST		38
ChainⁱPRO_0000001112	39 – 388	Fructose-bisphosphate aldolase, chloroplasticAdd BLAST		350

Proteomic databases

PaxDbⁱ	Q40677.
PRIDEⁱ	Q40677.

Expressionⁱ

Tissue specificityⁱ

Expressed in leaf mesophyll cells.1 Publication

Inductionⁱ

By exposure to light.1 Publication

Gene expression databases

ExpressionAtlasⁱ	Q40677. baseline and differential.
Genevisibleⁱ	Q40677. OS.

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Protein-protein interaction databases

IntActⁱ	Q40677. 1 interactor.
STRINGⁱ	39947.LOC_Os11g07020.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q40677.
SMRⁱ	Q40677.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	299 – 301	Substrate bindingBy similarity		3

Sequence similaritiesⁱ

Belongs to the class I fructose-bisphosphate aldolase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1557. Eukaryota. COG3588. LUCA.
HOGENOMⁱ	HOG000220876.
InParanoidⁱ	Q40677.
KEGG Orthology (KO) More...KOⁱ	K01623.
OMAⁱ	LKTWQGK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360CPA.

Family and domain databases

Gene3Dⁱ	3.20.20.70. 1 hit.
InterProⁱ	View protein in InterPro IPR029768. Aldolase_I_AS. IPR013785. Aldolase_TIM. IPR000741. FBA_I.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00274. Glycolytic. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00158. ALDOLASE_CLASS_I. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q40677-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASATLLKSS FLPKKSEWGA TRQAAAPKPV TVSMVVRAGA YDDELVKTAK 
        60         70         80         90        100
TIASPGRGIL AMDESNATCG KRLASIGLEN TEANRQAYRT LLVTAPGLGQ 
       110        120        130        140        150
YISGAILFEE TLYQSTVDGK KIVDILTEQK IVPGIKVDKG LVPLAGSNNE 
       160        170        180        190        200
SWCQGLDGLA SREAAYYQQG ARFAKWRTVV SIPNGPSELA VKEAAWGLAR 
       210        220        230        240        250
YAAISQDNGL VPIVEPEILL DGEHGIDRTF EVAQKVWAET FFYMAENNVM 
       260        270        280        290        300
FEGILLKPSM VTPGAECKDR ATPEQVSDYT LKLLHRRIPP AVPGIMFLSG 
       310        320        330        340        350
GQSEVEATQN LNAMNQGPNP WHVSFSYARA LQNTCLKTWG GQPENVKAAQ 
       360        370        380 
DALLLRAKAN SLAQLGKYTS DGEAAEAKEG MFVKNYVY

Length:388

Mass (Da):42,006

Last modified:October 25, 2005 - v2

Checksum:ⁱ4FFF6FAE1F6619E0

GO

Sequence cautionⁱ

The sequence AAX95073 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence ABA91631 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence ABA91632 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	156	L → R in BAA02730 (PubMed:8163192).Curated	1
Sequence conflictⁱ	294	G → A in BAA02730 (PubMed:8163192).Curated	1
Sequence conflictⁱ	352	A → R in BAA02730 (PubMed:8163192).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D13513 Genomic DNA. Translation: BAA02730.1. JX972166 mRNA. Translation: AGT38460.1. AC128643 Genomic DNA. Translation: AAX95072.1. AC128643 Genomic DNA. Translation: AAX95073.1. Sequence problems. DP000010 Genomic DNA. Translation: ABA91630.2. DP000010 Genomic DNA. Translation: ABA91631.2. Sequence problems. DP000010 Genomic DNA. Translation: ABA91632.2. Sequence problems. AP008217 Genomic DNA. Translation: BAF27707.1. AP014967 Genomic DNA. Translation: BAT12868.1. CM000148 Genomic DNA. Translation: EAZ17583.1. AK104899 mRNA. Translation: BAG97016.1.
PIRⁱ	T03679.
NCBI Reference Sequences More...RefSeqⁱ	XP_015616895.1. XM_015761409.1.
UniGeneⁱ	Os.7988.

Genome annotation databases

EnsemblPlantsⁱ	OS11T0171300-01; OS11T0171300-01; OS11G0171300.
GeneIDⁱ	4349897.
Grameneⁱ	OS11T0171300-01; OS11T0171300-01; OS11G0171300.
KEGGⁱ	osa:4349897.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q40677	I1QY31 A0A0E0IYS5 A2ZBX1 A0A1L2JN36 A0A0E0F2Z1 A0A0D3HIR1 A0A0E0R4S0 Q53P93	Oryza sativa subsp. japonica (Rice) Oryza glaberrima (African rice) Oryza nivara (Indian wild rice) Oryza sativa subsp. indica (Rice) Oryza sativa (Rice) Oryza meridionalis Oryza barthii Oryza rufipogon (Brownbeard rice) (Asian wild rice)	388	UniRef100_Q40677	Cluster: Fructose-bisphosphate aldolase, chloroplastic	9

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q40677	I1QY31 A0A0E0IYS5 A2ZBX1 A0A1L2JN36 A0A0E0F2Z1 A0A0D3HIR1 A0A0E0R4S0 Q53P93 A0A0A9P7M5 C5YSP7 +25	Oryza sativa subsp. japonica (Rice) Oryza glaberrima (African rice) Oryza nivara (Indian wild rice) Oryza sativa subsp. indica (Rice) Oryza sativa (Rice) Oryza meridionalis Oryza barthii Oryza rufipogon (Brownbeard rice) (Asian wild rice) Arundo donax (Giant reed) (Donax arundinaceus) Sorghum bicolor (Sorghum) (Sorghum vulgare) And more	388	UniRef90_Q40677	Cluster: Fructose-bisphosphate aldolase, chloroplastic	36

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q40677	Q944G9 A0A178UW98 R0HSY4 UPI00053C7062 M4EQV8 UPI0006AA79A3 D7LL27 UPI0006AA9516 A0A0D5YAC4 Q9SJU4 +240	Arabidopsis thaliana (Mouse-ear cress) Capsella rubella Tarenaya hassleriana Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis) Brassica napus (Rape) Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Brassica rapa subsp. chinensis (Pak-choi) Noccaea caerulescens (Alpine penny-cress) (Thlaspi caerulescens) Brassica campestris (Field mustard) Brassica oleracea var. oleracea And more	398	UniRef50_Q944G9	Cluster: Fructose-bisphosphate aldolase 2, chloroplastic	251

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D13513 Genomic DNA. Translation: BAA02730.1. JX972166 mRNA. Translation: AGT38460.1. AC128643 Genomic DNA. Translation: AAX95072.1. AC128643 Genomic DNA. Translation: AAX95073.1. Sequence problems. DP000010 Genomic DNA. Translation: ABA91630.2. DP000010 Genomic DNA. Translation: ABA91631.2. Sequence problems. DP000010 Genomic DNA. Translation: ABA91632.2. Sequence problems. AP008217 Genomic DNA. Translation: BAF27707.1. AP014967 Genomic DNA. Translation: BAT12868.1. CM000148 Genomic DNA. Translation: EAZ17583.1. AK104899 mRNA. Translation: BAG97016.1.
PIRⁱ	T03679.
NCBI Reference Sequences More...RefSeqⁱ	XP_015616895.1. XM_015761409.1.
UniGeneⁱ	Os.7988.

3D structure databases

ProteinModelPortalⁱ	Q40677.
SMRⁱ	Q40677.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q40677. 1 interactor.
STRINGⁱ	39947.LOC_Os11g07020.1.

Proteomic databases

PaxDbⁱ	Q40677.
PRIDEⁱ	Q40677.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	OS11T0171300-01; OS11T0171300-01; OS11G0171300.
GeneIDⁱ	4349897.
Grameneⁱ	OS11T0171300-01; OS11T0171300-01; OS11G0171300.
KEGGⁱ	osa:4349897.

Phylogenomic databases

eggNOGⁱ	KOG1557. Eukaryota. COG3588. LUCA.
HOGENOMⁱ	HOG000220876.
InParanoidⁱ	Q40677.
KEGG Orthology (KO) More...KOⁱ	K01623.
OMAⁱ	LKTWQGK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG09360CPA.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00183.

UniPathwayⁱ

UPA00109; UER00183.

Gene expression databases

ExpressionAtlasⁱ	Q40677. baseline and differential.
Genevisibleⁱ	Q40677. OS.

Family and domain databases

Gene3Dⁱ	3.20.20.70. 1 hit.
InterProⁱ	View protein in InterPro IPR029768. Aldolase_I_AS. IPR013785. Aldolase_TIM. IPR000741. FBA_I.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00274. Glycolytic. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00158. ALDOLASE_CLASS_I. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ALFP_ORYSJ
Accessionⁱ	Q40677Primary (citable) accession number: Q40677 Secondary accession number(s): Q2R9Z9 , Q2RA00, Q2RA01, Q53P95, Q53P96, U5KP25
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	October 25, 2005
	Last modified:	August 30, 2017
	This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q40677 (ALFP_ORYSJ)

Your basket is currently empty.

Fructose-bisphosphate aldolase, chloroplastic

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ