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Protein
Submitted name:

Chalcone reductase

Gene

CHR

Organism
Medicago sativa (Alfalfa)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531NADPCombined sources
Active sitei58 – 581Proton donorUniRule annotation
Binding sitei58 – 581NADPCombined sources
Binding sitei87 – 871NADPCombined sources
Sitei87 – 871Lowers pKa of active site TyrUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei188 – 1881NADPCombined sources
Binding sitei263 – 2631NADP; via amide nitrogenCombined sources
Binding sitei269 – 2691NADPCombined sources
Binding sitei273 – 2731NADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 304NADPCombined sources
Nucleotide bindingi166 – 1672NADPCombined sources
Nucleotide bindingi214 – 2196NADPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

NADPCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Chalcone reductaseImported
Gene namesi
Name:CHRImported
OrganismiMedicago sativa (Alfalfa)Imported
Taxonomic identifieri3879 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeTrifolieaeMedicago

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZGDX-ray1.70A/B1-312[»]
ProteinModelPortaliQ40309.
SMRiQ40309. Positions 5-312.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ40309.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 292262Aldo_ket_redInterPro annotationAdd
BLAST

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q40309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVEIPTKV LTNTSSQLKM PVVGMGSAPD FTCKKDTKDA IIEAIKQGYR
60 70 80 90 100
HFDTAAAYGS EQALGEALKE AIELGLVTRD DLFVTSKLWV TENHPHLVIP
110 120 130 140 150
ALQKSLKTLQ LDYLDLYLIH WPLSSQPGKF SFPIDVADLL PFDVKGVWES
160 170 180 190 200
MEESLKLGLT KAIGVSNFSV KKLENLLSVA TVLPAVNQVE MNLAWQQKKL
210 220 230 240 250
REFCNAHGIV LTAFSPVRKG ASRGPNEVME NDMLKEIADA HGKSVAQISL
260 270 280 290 300
RWLYEQGVTF VPKSYDKERM NQNLRIFDWS LTKEDHEKIA QIKQNRLIPG
310
PTKPGLNDLY DD
Length:312
Mass (Da):34,893
Last modified:November 1, 1996 - v1
Checksum:iBA68E76644FF60D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13924 mRNA. Translation: AAB41555.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13924 mRNA. Translation: AAB41555.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZGDX-ray1.70A/B1-312[»]
ProteinModelPortaliQ40309.
SMRiQ40309. Positions 5-312.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ40309.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ40309_MEDSA
AccessioniPrimary (citable) accession number: Q40309
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.