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Protein

Major allergen Mal d 1

Gene
N/A
Organism
Malus domestica (Apple) (Pyrus malus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Mal d 1
Alternative name(s):
AP15
Allergen Mal d I
Allergen: Mal d 1
OrganismiMalus domestica (Apple) (Pyrus malus)
Taxonomic identifieri3750 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1456. Mal d 1.0201.
1461. Mal d 1.0206.
464. Mal d 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001541912 – 159Major allergen Mal d 1Add BLAST158

Structurei

3D structure databases

ProteinModelPortaliQ40280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q40280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVYTFENEY TSEIPPPRLF KAFVLDADNL IPKIAPQAIK HAEILEGDGG
60 70 80 90 100
PGTIKKITFG EGSQYGYVKH KIDSVDEANY SYAYTLIEGD ALTDTIEKVS
110 120 130 140 150
YETKLVASGS GSIIKSISHY HTKGDVEIKE EHVKAGKEKA HGLFKLIESY

LKGHPDAYN
Length:159
Mass (Da):17,539
Last modified:January 23, 2007 - v3
Checksum:i7332100D2C614446
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti22A → G.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42952 mRNA. Translation: AAB01362.1.
AF074721 mRNA. Translation: AAC26136.1.
AF020542 Genomic DNA. Translation: AAD13683.1.
RefSeqiNP_001281292.1. NM_001294363.1.
UniGeneiMdo.3014.

Genome annotation databases

GeneIDi103425638.
KEGGimdm:103425638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42952 mRNA. Translation: AAB01362.1.
AF074721 mRNA. Translation: AAC26136.1.
AF020542 Genomic DNA. Translation: AAD13683.1.
RefSeqiNP_001281292.1. NM_001294363.1.
UniGeneiMdo.3014.

3D structure databases

ProteinModelPortaliQ40280.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1456. Mal d 1.0201.
1461. Mal d 1.0206.
464. Mal d 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103425638.
KEGGimdm:103425638.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAL12_MALDO
AccessioniPrimary (citable) accession number: Q40280
Secondary accession number(s): O22517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.