ID   INO1_MESCR              Reviewed;         512 AA.
AC   Q40271;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol-1-phosphate synthase;
DE            Short=MI-1-P synthase;
DE            Short=IPS;
OS   Mesembryanthemum crystallinum (Common ice plant).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   Caryophyllales; Aizoaceae; Mesembryanthemum.
OX   NCBI_TaxID=3544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=96208959; PubMed=8624516;
RX   DOI=10.1046/j.1365-313X.1996.09040537.x;
RA   Ishitani M., Majumder A.L., Bornhouser A., Michalowski C.B.,
RA   Jensen R.G., Bohnert H.J.;
RT   "Coordinate transcriptional induction of myo-inositol metabolism
RT   during environmental stress.";
RL   Plant J. 9:537-548(1996).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate = 1D-myo-inositol 3-
CC       phosphate.
CC   -!- COFACTOR: NAD (By similarity).
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-
CC       inositol from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the myo-inositol-1-phosphate synthase
CC       family.
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DR   EMBL; U32511; AAB03687.1; -; mRNA.
DR   PIR; T12438; T12438.
DR   HSSP; P11986; 1P1K.
DR   BRENDA; 5.5.1.4; 2210.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11510; Inos-1-P_synth; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; NAD;
KW   Phospholipid biosynthesis.
FT   CHAIN         1    512       Inositol-3-phosphate synthase.
FT                                /FTId=PRO_0000195193.
SQ   SEQUENCE   512 AA;  56759 MW;  DF4B7109F47E8516 CRC64;
     MFIESFKVES PNVKYTENEI ESVYNYDTTE LVHENRKDAG GYQWIVKPKT VQYHFKTDTR
     VPKLGVMLVG WGGNNGSTLT GGVIANREGI SWATKDKIQQ ANYFGSLTQA SSIRVGSFNG
     EEIYAPFKSL LPMVNPDDVV FGGWDISDMN LADAMTRARV FDIDLQKQLR PYMEHMVPLP
     GIYDPDFIAA NQGSRANNVI KGTKKEQVER VIKDIREFKE KNKVDKVVVL WTGNTERYSN
     VVVGLNDTME NLLASLEKNE SEISPSTSYA LACIEENIPF INGSPQNTFV PGLIDLAIKK
     NSLIGGDDFK SGQTKMKSVL VDFLVGAGIK PTSIVSYNHL GNNDGMNLSA PQTFRSKEIS
     KSNVVDDMVA SNGILYEPGE HPDHVVVIKY VPYVGDSKRA MDEYTSEIFM GGTNTIVMHN
     TCEDSLLAAP IILDLVLLAE LSTRIQLKAE EEDKFHSFHP VATILSYLTK APLVPPGTPV
     VNALSKQRAM LENILRACVG LAPENNMILE YK
//