Q40271 (INO1_MESCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Inositol-3-phosphate synthase Short name=MIP synthase EC=5.5.1.4 Alternative name(s): Myo-inositol-1-phosphate synthase Short name=IPS Short name=MI-1-P synthase
Organism	Mesembryanthemum crystallinum (Common ice plant) (Cryophytum crystallinum)
Taxonomic identifier	3544 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Aizoaceae › Mesembryanthemum

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
Cofactor	NAD By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the myo-inositol-1-phosphate synthase family.

Ontologies

Keywords
Biological process	Inositol biosynthesis Phospholipid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	inositol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inositol-3-phosphate synthase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Inositol-3-phosphate synthase		PRO_0000195193

Sequences

	Sequence		Length	Mass (Da)
	Q40271 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: DF4B7109F47E8516	FASTA	512	56,759
	10 20 30 40 50 60 MFIESFKVES PNVKYTENEI ESVYNYDTTE LVHENRKDAG GYQWIVKPKT VQYHFKTDTR 70 80 90 100 110 120 VPKLGVMLVG WGGNNGSTLT GGVIANREGI SWATKDKIQQ ANYFGSLTQA SSIRVGSFNG 130 140 150 160 170 180 EEIYAPFKSL LPMVNPDDVV FGGWDISDMN LADAMTRARV FDIDLQKQLR PYMEHMVPLP 190 200 210 220 230 240 GIYDPDFIAA NQGSRANNVI KGTKKEQVER VIKDIREFKE KNKVDKVVVL WTGNTERYSN 250 260 270 280 290 300 VVVGLNDTME NLLASLEKNE SEISPSTSYA LACIEENIPF INGSPQNTFV PGLIDLAIKK 310 320 330 340 350 360 NSLIGGDDFK SGQTKMKSVL VDFLVGAGIK PTSIVSYNHL GNNDGMNLSA PQTFRSKEIS 370 380 390 400 410 420 KSNVVDDMVA SNGILYEPGE HPDHVVVIKY VPYVGDSKRA MDEYTSEIFM GGTNTIVMHN 430 440 450 460 470 480 TCEDSLLAAP IILDLVLLAE LSTRIQLKAE EEDKFHSFHP VATILSYLTK APLVPPGTPV 490 500 510 VNALSKQRAM LENILRACVG LAPENNMILE YK

References

[1]	"Coordinate transcriptional induction of myo-inositol metabolism during environmental stress." Ishitani M., Majumder A.L., Bornhouser A., Michalowski C.B., Jensen R.G., Bohnert H.J. Plant J. 9:537-548(1996) [PubMed: 8624516] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U32511 mRNA. Translation: AAB03687.1.
PIR	T12438.
3D structure databases
ProteinModelPortal	Q40271.
SMR	Q40271. Positions 4-512.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002587. Myo-inos-1-P_Synthase. IPR013021. Myo-inos-1-P_Synthase_GAPDH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
PANTHER	PTHR11510. Inos-1-P_synth. 1 hit.
Pfam	PF01658. Inos-1-P_synth. 1 hit. PF07994. NAD_binding_5. 1 hit. [Graphical view]
PIRSF	PIRSF015578. Myoinos-ppht_syn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

INO1_MESCR

Accession

Primary (citable) accession number: Q40271

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program