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Q40255

- ALDH_LINUS

UniProt

Q40255 - ALDH_LINUS

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Protein
Probable aldehyde dehydrogenase
Gene
FIS1
Organism
Linum usitatissimum (Flax) (Linum humile)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Could be involved in facilitating the biotrophic relationship between the plant and the rust fungus.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei203 – 2031Transition state stabilizer By similarity
Active sitei297 – 2971Proton acceptor By similarity
Active sitei332 – 3321Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi278 – 2836NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aldehyde dehydrogenase (EC:1.2.1.3)
Alternative name(s):
Flax-inducible sequence 1
Gene namesi
Name:FIS1
OrganismiLinum usitatissimum (Flax) (Linum humile)
Taxonomic identifieri4006 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesLinaceaeLinum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Probable aldehyde dehydrogenase
PRO_0000056433Add
BLAST

Expressioni

Tissue specificityi

In uninfected plants, highest levels found in stems. In plants infected with the flax rust, highest levels in leaves. Higher levels of expression in infected leaves than uninfected stems.

Inductioni

By flax rust susceptible infection but not by resistant infection. Levels 10-fold higher in infected plants than uninfected plants.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ40255.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q40255-1 [UniParc]FASTAAdd to Basket

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MYRPLVARLL RDSVATRKGS SHFARRFSHS LPFATVDAEE LSGAKPAEVL    50
NLVQGNWGGS SSWHTVVDPL NGEPFIKVAE VDETEIKPFV ESLSKCPKHG 100
LHNPFKSPER YLLYGDISTK AGHMLSIPKV SEFFARLIQR VAPKSYHQAL 150
GEVQVTQKFF ENFTGDQVRF LARSFGVPGN HLGQQSNGFR WPFGPVAIIT 200
PFNFPLEIPV LQLMGALYMG NKPLLKVDSK VSIVMEQMMR LLHYCGLPVG 250
DADFVNSDGK AMNKILLEAN PRMTLFTGSS RVAEKLALDL KGRIKLEDAG 300
FDWKILGPDV NEADYVAWVC DQDAYACSGQ KCSAQSILFM HENWAATPLI 350
SRLKELAERR KLEDLTVGPV LTVTTEAMLD HLNKLLQIPG AKLLFGGKPL 400
ENHTIPSIYG AVKPTAVYVP LEEILKVSNY ELVTKEIFGP FQVVTEYKNS 450
QLPMVLEALE RMHAHLTAAV VSNDQLFLQE VIGNTVNGTT YAGLRARTTG 500
APQNHWFGPA GDPRGAGIGT PEAIKLVWSC HREIIYDIGP VSHHWEIPPS 550
T 551
Length:551
Mass (Da):61,032
Last modified:November 1, 1996 - v1
Checksum:iF1B87A79D76E863E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86733 mRNA. Translation: CAA60412.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86733 mRNA. Translation: CAA60412.1 .

3D structure databases

ProteinModelPortali Q40255.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a flax (Linum usitatissimum) gene induced during susceptible infection by flax rust (Melampsora lini)."
    Roberts J.K., Pryor A.
    Plant J. 8:1-8(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: cv. Hoshangabad.
    Tissue: Seedling leaf.

Entry informationi

Entry nameiALDH_LINUS
AccessioniPrimary (citable) accession number: Q40255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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