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Q40255

- ALDH_LINUS

UniProt

Q40255 - ALDH_LINUS

Protein

Probable aldehyde dehydrogenase

Gene

FIS1

Organism
Linum usitatissimum (Flax) (Linum humile)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Could be involved in facilitating the biotrophic relationship between the plant and the rust fungus.

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei203 – 2031Transition state stabilizerBy similarity
    Active sitei297 – 2971Proton acceptorPROSITE-ProRule annotation
    Active sitei332 – 3321NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi278 – 2836NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable aldehyde dehydrogenase (EC:1.2.1.3)
    Alternative name(s):
    Flax-inducible sequence 1
    Gene namesi
    Name:FIS1
    OrganismiLinum usitatissimum (Flax) (Linum humile)
    Taxonomic identifieri4006 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesLinaceaeLinum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Probable aldehyde dehydrogenasePRO_0000056433Add
    BLAST

    Expressioni

    Tissue specificityi

    In uninfected plants, highest levels found in stems. In plants infected with the flax rust, highest levels in leaves. Higher levels of expression in infected leaves than uninfected stems.

    Inductioni

    By flax rust susceptible infection but not by resistant infection. Levels 10-fold higher in infected plants than uninfected plants.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ40255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q40255-1 [UniParc]FASTAAdd to Basket

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    MYRPLVARLL RDSVATRKGS SHFARRFSHS LPFATVDAEE LSGAKPAEVL    50
    NLVQGNWGGS SSWHTVVDPL NGEPFIKVAE VDETEIKPFV ESLSKCPKHG 100
    LHNPFKSPER YLLYGDISTK AGHMLSIPKV SEFFARLIQR VAPKSYHQAL 150
    GEVQVTQKFF ENFTGDQVRF LARSFGVPGN HLGQQSNGFR WPFGPVAIIT 200
    PFNFPLEIPV LQLMGALYMG NKPLLKVDSK VSIVMEQMMR LLHYCGLPVG 250
    DADFVNSDGK AMNKILLEAN PRMTLFTGSS RVAEKLALDL KGRIKLEDAG 300
    FDWKILGPDV NEADYVAWVC DQDAYACSGQ KCSAQSILFM HENWAATPLI 350
    SRLKELAERR KLEDLTVGPV LTVTTEAMLD HLNKLLQIPG AKLLFGGKPL 400
    ENHTIPSIYG AVKPTAVYVP LEEILKVSNY ELVTKEIFGP FQVVTEYKNS 450
    QLPMVLEALE RMHAHLTAAV VSNDQLFLQE VIGNTVNGTT YAGLRARTTG 500
    APQNHWFGPA GDPRGAGIGT PEAIKLVWSC HREIIYDIGP VSHHWEIPPS 550
    T 551
    Length:551
    Mass (Da):61,032
    Last modified:November 1, 1996 - v1
    Checksum:iF1B87A79D76E863E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86733 mRNA. Translation: CAA60412.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86733 mRNA. Translation: CAA60412.1 .

    3D structure databases

    ProteinModelPortali Q40255.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a flax (Linum usitatissimum) gene induced during susceptible infection by flax rust (Melampsora lini)."
      Roberts J.K., Pryor A.
      Plant J. 8:1-8(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Strain: cv. Hoshangabad.
      Tissue: Seedling leaf.

    Entry informationi

    Entry nameiALDH_LINUS
    AccessioniPrimary (citable) accession number: Q40255
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3