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Q40255 (ALDH_LINUS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable aldehyde dehydrogenase
EC=1.2.1.3
Alternative name(s):
Flax-inducible sequence 1
Gene names
Name:FIS1
OrganismLinum usitatissimum (Flax) (Linum humile)
Taxonomic identifier4006 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Linaceae › Linum

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could be involved in facilitating the biotrophic relationship between the plant and the rust fungus.

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Tissue specificity

In uninfected plants, highest levels found in stems. In plants infected with the flax rust, highest levels in leaves. Higher levels of expression in infected leaves than uninfected stems.

Induction

By flax rust susceptible infection but not by resistant infection. Levels 10-fold higher in infected plants than uninfected plants. Ref.1

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Probable aldehyde dehydrogenase
PRO_0000056433

Regions

Nucleotide binding278 – 2836NAD By similarity

Sites

Active site2971Proton acceptor By similarity
Active site3321Nucleophile By similarity
Site2031Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q40255 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F1B87A79D76E863E

FASTA55161,032
        10         20         30         40         50         60 
MYRPLVARLL RDSVATRKGS SHFARRFSHS LPFATVDAEE LSGAKPAEVL NLVQGNWGGS 

        70         80         90        100        110        120 
SSWHTVVDPL NGEPFIKVAE VDETEIKPFV ESLSKCPKHG LHNPFKSPER YLLYGDISTK 

       130        140        150        160        170        180 
AGHMLSIPKV SEFFARLIQR VAPKSYHQAL GEVQVTQKFF ENFTGDQVRF LARSFGVPGN 

       190        200        210        220        230        240 
HLGQQSNGFR WPFGPVAIIT PFNFPLEIPV LQLMGALYMG NKPLLKVDSK VSIVMEQMMR 

       250        260        270        280        290        300 
LLHYCGLPVG DADFVNSDGK AMNKILLEAN PRMTLFTGSS RVAEKLALDL KGRIKLEDAG 

       310        320        330        340        350        360 
FDWKILGPDV NEADYVAWVC DQDAYACSGQ KCSAQSILFM HENWAATPLI SRLKELAERR 

       370        380        390        400        410        420 
KLEDLTVGPV LTVTTEAMLD HLNKLLQIPG AKLLFGGKPL ENHTIPSIYG AVKPTAVYVP 

       430        440        450        460        470        480 
LEEILKVSNY ELVTKEIFGP FQVVTEYKNS QLPMVLEALE RMHAHLTAAV VSNDQLFLQE 

       490        500        510        520        530        540 
VIGNTVNGTT YAGLRARTTG APQNHWFGPA GDPRGAGIGT PEAIKLVWSC HREIIYDIGP 

       550 
VSHHWEIPPS T

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References

[1]"Isolation of a flax (Linum usitatissimum) gene induced during susceptible infection by flax rust (Melampsora lini)."
Roberts J.K., Pryor A.
Plant J. 8:1-8(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
Strain: cv. Hoshangabad.
Tissue: Seedling leaf.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X86733 mRNA. Translation: CAA60412.1.

3D structure databases

ProteinModelPortalQ40255.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_LINUS
AccessionPrimary (citable) accession number: Q40255
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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