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Q40255

- ALDH_LINUS

UniProt

Q40255 - ALDH_LINUS

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Protein

Probable aldehyde dehydrogenase

Gene

FIS1

Organism
Linum usitatissimum (Flax) (Linum humile)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Could be involved in facilitating the biotrophic relationship between the plant and the rust fungus.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei203 – 2031Transition state stabilizerBy similarity
Active sitei297 – 2971Proton acceptorPROSITE-ProRule annotation
Active sitei332 – 3321NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi278 – 2836NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aldehyde dehydrogenase (EC:1.2.1.3)
Alternative name(s):
Flax-inducible sequence 1
Gene namesi
Name:FIS1
OrganismiLinum usitatissimum (Flax) (Linum humile)
Taxonomic identifieri4006 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesLinaceaeLinum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Probable aldehyde dehydrogenasePRO_0000056433Add
BLAST

Expressioni

Tissue specificityi

In uninfected plants, highest levels found in stems. In plants infected with the flax rust, highest levels in leaves. Higher levels of expression in infected leaves than uninfected stems.

Inductioni

By flax rust susceptible infection but not by resistant infection. Levels 10-fold higher in infected plants than uninfected plants.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ40255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q40255-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRPLVARLL RDSVATRKGS SHFARRFSHS LPFATVDAEE LSGAKPAEVL
60 70 80 90 100
NLVQGNWGGS SSWHTVVDPL NGEPFIKVAE VDETEIKPFV ESLSKCPKHG
110 120 130 140 150
LHNPFKSPER YLLYGDISTK AGHMLSIPKV SEFFARLIQR VAPKSYHQAL
160 170 180 190 200
GEVQVTQKFF ENFTGDQVRF LARSFGVPGN HLGQQSNGFR WPFGPVAIIT
210 220 230 240 250
PFNFPLEIPV LQLMGALYMG NKPLLKVDSK VSIVMEQMMR LLHYCGLPVG
260 270 280 290 300
DADFVNSDGK AMNKILLEAN PRMTLFTGSS RVAEKLALDL KGRIKLEDAG
310 320 330 340 350
FDWKILGPDV NEADYVAWVC DQDAYACSGQ KCSAQSILFM HENWAATPLI
360 370 380 390 400
SRLKELAERR KLEDLTVGPV LTVTTEAMLD HLNKLLQIPG AKLLFGGKPL
410 420 430 440 450
ENHTIPSIYG AVKPTAVYVP LEEILKVSNY ELVTKEIFGP FQVVTEYKNS
460 470 480 490 500
QLPMVLEALE RMHAHLTAAV VSNDQLFLQE VIGNTVNGTT YAGLRARTTG
510 520 530 540 550
APQNHWFGPA GDPRGAGIGT PEAIKLVWSC HREIIYDIGP VSHHWEIPPS

T
Length:551
Mass (Da):61,032
Last modified:November 1, 1996 - v1
Checksum:iF1B87A79D76E863E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86733 mRNA. Translation: CAA60412.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86733 mRNA. Translation: CAA60412.1 .

3D structure databases

ProteinModelPortali Q40255.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a flax (Linum usitatissimum) gene induced during susceptible infection by flax rust (Melampsora lini)."
    Roberts J.K., Pryor A.
    Plant J. 8:1-8(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: cv. Hoshangabad.
    Tissue: Seedling leaf.

Entry informationi

Entry nameiALDH_LINUS
AccessioniPrimary (citable) accession number: Q40255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3