Q40237 (MPA5B_LOLPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Major pollen allergen Lol p 5b Alternative name(s): Allergen Lol p Vb Allergen=Lol p 5b
Organism	Lolium perenne (Perennial ryegrass)
Taxonomic identifier	4522 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Pooideae › Poeae › Loliinae › Lolium

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Note: Starch granule By similarity.
Tissue specificity	Pollen, starch granules.
Allergenic properties	Causes an allergic reaction in human. Causes grass pollen allergy.
Sequence similarities	Belongs to the Poa p IX/Phl p VI allergen family.

Ontologies

Keywords
Disease	Allergen
Domain	Repeat Signal
Gene Ontology (GO)
Biological_process	type I hypersensitivity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 339	314	Major pollen allergen Lol p 5b		PRO_0000021745
Regions
	Repeat	32 – 34	3	1-1
	Repeat	35 – 37	3	1-2
	Repeat	38 – 40	3	1-3
	Repeat	41 – 43	3	1-4
	Repeat	44 – 46	3	1-5
	Repeat	47 – 49	3	1-6
	Repeat	50 – 52	3	1-7
	Repeat	53 – 55	3	1-8
	Repeat	56 – 58	3	1-9
	Repeat	285 – 290	6	2-1; truncated
	Repeat	292 – 300	9	2-2
	Repeat	301 – 309	9	2-3
	Repeat	310 – 318	9	2-4
	Repeat	319 – 327	9	2-5
	Repeat	328 – 334	7	2-6; truncated
	Region	32 – 58	27	9 X 3 AA tandem repeats of [PA]-A-[TA]
	Region	285 – 334	50	6 X 9 AA approximate tandem repeats of T-A-T-A-T-P-A-A-A
	Compositional bias	81 – 87	7	Poly-Ala
	Compositional bias	288 – 293	6	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	Q40237 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3CAA3115625E0610	FASTA	339	33,750
	10 20 30 40 50 60 MAVQKHTVAL FLAVALVAGP AASYAADAGY APATPATPAA PATAATPATP ATPATPAAVP 70 80 90 100 110 120 SGKATTEEQK LIEKINAGFK AAVAAAAVVP PADKYKTFVE TFGTATNKAF VEGLASGYAD 130 140 150 160 170 180 QSKNQLTSKL DAALKLAYEA AQGATPEAKY DAYVATLTEA LRVIAGTLEV HAVKPAAEEV 190 200 210 220 230 240 KVGAIPAAEV QLIDKVDAAY RTAATAANAA PANDKFTVFE NTFNNAIKVS LGAAYDSYKF 250 260 270 280 290 300 IPTLVAAVKQ AYAAKQATAP EVKYTVSETA LKKAVTAMSE AEKEATPAAA ATATPTPAAA 310 320 330 TATATPAAAY ATATPAAATA TATPAAATAT PAAAGGYKV

References

[1]

"Cloning of a cDNA encoding a group-V (group-IX) allergen isoform from rye-grass pollen that demonstrates specific antigenic immunoreactivity." Ong E.K., Griffith I.J., Knox R.B., Singh M.B. Gene 134:235-240(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pollen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13083 mRNA. Translation: AAA33405.1.
PIR	JT0756.
3D structure databases
ProteinModelPortal	Q40237.
SMR	Q40237. Positions 64-173, 185-283.
ModBase	Search...
Protein family/group databases
Allergome	460. Lol p 5. 461. Lol p 5.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	Q40237.
Family and domain databases
Gene3D	1.20.120.320. 2 hits.
InterPro	IPR001778. POA_allergen. IPR002914. POA_allergen_N. [Graphical view]
Pfam	PF01620. Pollen_allerg_2. 2 hits. [Graphical view]
PRINTS	PR00833. POAALLERGEN.
SUPFAM	SSF81736. POA_allergen_N. 2 hits.
ProtoNet	Search...

Entry information

Entry name

MPA5B_LOLPR

Accession

Primary (citable) accession number: Q40237

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program