Q401N2Q2TB29Q6ZWK3Q86YW4ZACN_HUMANLigand-gated cation channel ZACNLigand-gated ion channel zinc-activated 1Ligand-gated ion-channel receptor L2Zinc-activated channelZACNL2LGICZLGICZ1ZACHomo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoA novel class of ligand-gated ion channel is activated by Zn2+.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)FUNCTIONTISSUE SPECIFICITYVARIANT THR-152Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)SUBCELLULAR LOCATIONTISSUE SPECIFICITYGLYCOSYLATIONComplete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)VARIANT THR-152DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)Copper and protons directly activate the zinc-activated channel.FUNCTIONTRANSPORTER ACTIVITYACTIVITY REGULATIONSUBCELLULAR LOCATIONLigand-gated cation channel that allows the movement of sodium and potassium monoatomic cations across cell membranes when activated by zinc (Zn2+), copper (Cu2+), and changes in pH (PubMed:26872532). Could also transport cesium (PubMed:26872532).Na(+)(in) = Na(+)(out)K(+)(in) = K(+)(out)Inhibited by the divalent cations magnesium and calcium.Cell membraneMulti-pass membrane proteinQ401N2-11Q401N2-22Q401N2-33Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.Glycosylated.Isoform 3May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Belongs to the ligand-gated ion channel (TC 1.A.9) family.It is uncertain whether Met-1 or Met-2 is the initiator.Truncated N-terminus.Truncated N-terminus.Truncated N-terminus.Alternative splicingCell membraneDisulfide bondGlycoproteinIon channelIon transportLigand-gated ion channelMembraneReceptorReference proteomeSignalTransmembraneTransmembrane helixTransportZincDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPWESLWTPRLTILEALSSVLPRATALHSHGDCSGSAPCSKARGSGCHGLTPGNHLKVQPPCINPSGDIAMELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVGADRAGAAGLRRGGGRWGRGTPRSVVQGQGAGQGEGAKADRRRTPRSVFRAVYPRLRRAAPALPLRPPLEWQPISVLSGSLRAPLATMMALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPWESLWTPRLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALSNTAMELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPRGEQREHGNPGPHPAEEPSRGVKGSQRSWPETADRIFFLVYVVGVLCTQFVFAGIWMWAACKSDAAPGEAAPHGRRPRL
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