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Q401N2

- ZACN_HUMAN

UniProt

Q401N2 - ZACN_HUMAN

Protein

Zinc-activated ligand-gated ion channel

Gene

ZACN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Zinc-activated ligand-gated ion channel.1 Publication

    GO - Molecular functioni

    1. extracellular ligand-gated ion channel activity Source: InterPro
    2. ligand-gated ion channel activity Source: BHF-UCL
    3. zinc ion binding Source: HGNC

    GO - Biological processi

    1. ion transmembrane transport Source: BHF-UCL
    2. response to zinc ion Source: HGNC

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc-activated ligand-gated ion channel
    Alternative name(s):
    Ligand-gated ion channel zinc-activated 1
    Ligand-gated ion-channel receptor L2
    Gene namesi
    Name:ZACN
    Synonyms:L2, LGICZ, LGICZ1, ZAC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:29504. ZACN.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: HGNC

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409377.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 412387Zinc-activated ligand-gated ion channelPRO_0000317165Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi157 ↔ 171By similarity
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence AnalysisPRO_5000052473

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ401N2.
    PRIDEiQ401N2.

    Expressioni

    Tissue specificityi

    Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.2 Publications

    Gene expression databases

    BgeeiQ401N2.
    CleanExiHS_ZACN.
    GenevestigatoriQ401N2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000334854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ401N2.
    SMRiQ401N2. Positions 52-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 233208ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini255 – 26511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini287 – 29812ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini320 – 36849CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini390 – 41223ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei234 – 25421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921Helical; Name=4Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi224 – 31895Leu-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG121521.
    HOGENOMiHOG000155757.
    HOVERGENiHBG108756.
    InParanoidiQ401N2.
    KOiK16888.
    OMAiLVPCFQV.
    OrthoDBiEOG7M98GM.
    PhylomeDBiQ401N2.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 1 hit.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q401N2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMALWSLLHL TFLGFSITLL LVHGQGFQGT AAIWPSLFNV NLSKKVQESI    50
    QIPNNGSAPL LVDVRVFVSN VFNVDILRYT MSSMLLLRLS WLDTRLAWNT 100
    SAHPRHAITL PWESLWTPRL TILEALWVDW RDQSPQARVD QDGHVKLNLA 150
    LATETNCNFE LLHFPRDHSN CSLSFYALSN TAMELEFQAH VVNEIVSVKR 200
    EYVVYDLKTQ VPPQQLVPCF QVTLRLKNTA LKSIIALLVP AEALLLADVC 250
    GGLLPLRAIE RIGYKVTLLL SYLVLHSSLV QALPSSSSCN PLLIYYFTIL 300
    LLLLFLSTIE TVLLAGLLAR GNLGAKSGPS PAPRGEQREH GNPGPHPAEE 350
    PSRGVKGSQR SWPETADRIF FLVYVVGVLC TQFVFAGIWM WAACKSDAAP 400
    GEAAPHGRRP RL 412
    Length:412
    Mass (Da):45,816
    Last modified:February 5, 2008 - v2
    Checksum:iB894A28F5163723F
    GO
    Isoform 2 (identifier: Q401N2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         182-266: AMELEFQAHV...RAIERIGYKV → GADRAGAAGL...VLSGSLRAPL
         267-412: Missing.

    Show »
    Length:266
    Mass (Da):29,616
    Checksum:i06C2C8684090C9C8
    GO
    Isoform 3 (identifier: Q401N2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-126: DILRYTMSSM...TPRLTILEAL → SSVLPRATAL...PPCINPSGDI
         127-412: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:126
    Mass (Da):13,299
    Checksum:i9F87FF81BAB98B5F
    GO

    Sequence cautioni

    The sequence AAI10598.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAO20969.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence EAW89365.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti152 – 1521A → T.2 Publications
    Corresponds to variant rs2257020 [ dbSNP | Ensembl ].
    VAR_038483

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei75 – 12652DILRY…ILEAL → SSVLPRATALHSHGDCSGSA PCSKARGSGCHGLTPGNHLK VQPPCINPSGDI in isoform 3. 1 PublicationVSP_030909Add
    BLAST
    Alternative sequencei127 – 412286Missing in isoform 3. 1 PublicationVSP_030910Add
    BLAST
    Alternative sequencei182 – 26685AMELE…IGYKV → GADRAGAAGLRRGGGRWGRG TPRSVVQGQGAGQGEGAKAD RRRTPRSVFRAVYPRLRRAA PALPLRPPLEWQPISVLSGS LRAPL in isoform 2. 2 PublicationsVSP_030911Add
    BLAST
    Alternative sequencei267 – 412146Missing in isoform 2. 2 PublicationsVSP_030912Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF512521 mRNA. Translation: AAO20969.1. Different initiation.
    AB223030 mRNA. Translation: BAE19924.1.
    AK122638 mRNA. No translation available.
    AC018665 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89365.1. Different initiation.
    CH471099 Genomic DNA. Translation: EAW89366.1.
    BC110596 mRNA. No translation available.
    BC110597 mRNA. Translation: AAI10598.1. Different initiation.
    CCDSiCCDS11740.2. [Q401N2-1]
    RefSeqiNP_851321.2. NM_180990.3. [Q401N2-1]
    UniGeneiHs.714919.

    Genome annotation databases

    EnsembliENST00000334586; ENSP00000334854; ENSG00000186919. [Q401N2-1]
    ENST00000421794; ENSP00000391936; ENSG00000186919. [Q401N2-3]
    ENST00000425015; ENSP00000397489; ENSG00000186919. [Q401N2-2]
    GeneIDi353174.
    KEGGihsa:353174.
    UCSCiuc002jqn.2. human. [Q401N2-1]

    Polymorphism databases

    DMDMi166991030.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF512521 mRNA. Translation: AAO20969.1 . Different initiation.
    AB223030 mRNA. Translation: BAE19924.1 .
    AK122638 mRNA. No translation available.
    AC018665 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89365.1 . Different initiation.
    CH471099 Genomic DNA. Translation: EAW89366.1 .
    BC110596 mRNA. No translation available.
    BC110597 mRNA. Translation: AAI10598.1 . Different initiation.
    CCDSi CCDS11740.2. [Q401N2-1 ]
    RefSeqi NP_851321.2. NM_180990.3. [Q401N2-1 ]
    UniGenei Hs.714919.

    3D structure databases

    ProteinModelPortali Q401N2.
    SMRi Q401N2. Positions 52-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000334854.

    Chemistry

    ChEMBLi CHEMBL1628479.
    GuidetoPHARMACOLOGYi 587.

    Polymorphism databases

    DMDMi 166991030.

    Proteomic databases

    PaxDbi Q401N2.
    PRIDEi Q401N2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334586 ; ENSP00000334854 ; ENSG00000186919 . [Q401N2-1 ]
    ENST00000421794 ; ENSP00000391936 ; ENSG00000186919 . [Q401N2-3 ]
    ENST00000425015 ; ENSP00000397489 ; ENSG00000186919 . [Q401N2-2 ]
    GeneIDi 353174.
    KEGGi hsa:353174.
    UCSCi uc002jqn.2. human. [Q401N2-1 ]

    Organism-specific databases

    CTDi 353174.
    GeneCardsi GC17P074075.
    H-InvDB HIX0027141.
    HGNCi HGNC:29504. ZACN.
    MIMi 610935. gene.
    neXtProti NX_Q401N2.
    PharmGKBi PA162409377.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG121521.
    HOGENOMi HOG000155757.
    HOVERGENi HBG108756.
    InParanoidi Q401N2.
    KOi K16888.
    OMAi LVPCFQV.
    OrthoDBi EOG7M98GM.
    PhylomeDBi Q401N2.
    TreeFami TF315605.

    Miscellaneous databases

    ChiTaRSi ZACN. human.
    GeneWikii Zinc-activated_ion_channel.
    GenomeRNAii 353174.
    NextBioi 99731.
    PROi Q401N2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q401N2.
    CleanExi HS_ZACN.
    Genevestigatori Q401N2.

    Family and domain databases

    Gene3Di 1.20.120.370. 1 hit.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel class of ligand-gated ion channel is activated by Zn2+."
      Davies P.A., Wang W., Hales T.G., Kirkness E.F.
      J. Biol. Chem. 278:712-717(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, VARIANT THR-152.
    2. "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system."
      Houtani T., Munemoto Y., Kase M., Sakuma S., Tsutsumi T., Sugimoto T.
      Biochem. Biophys. Res. Commun. 335:277-285(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-152.
      Tissue: Thymus.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).

    Entry informationi

    Entry nameiZACN_HUMAN
    AccessioniPrimary (citable) accession number: Q401N2
    Secondary accession number(s): Q2TB29, Q6ZWK3, Q86YW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The mouse and rat orthologous proteins do not exist.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3