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Q401N2

- ZACN_HUMAN

UniProt

Q401N2 - ZACN_HUMAN

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Protein

Zinc-activated ligand-gated ion channel

Gene
ZACN, L2, LGICZ, LGICZ1, ZAC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Zinc-activated ligand-gated ion channel.1 Publication

GO - Molecular functioni

  1. extracellular ligand-gated ion channel activity Source: InterPro
  2. ligand-gated ion channel activity Source: BHF-UCL
  3. zinc ion binding Source: HGNC

GO - Biological processi

  1. ion transmembrane transport Source: BHF-UCL
  2. response to zinc ion Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-activated ligand-gated ion channel
Alternative name(s):
Ligand-gated ion channel zinc-activated 1
Ligand-gated ion-channel receptor L2
Gene namesi
Name:ZACN
Synonyms:L2, LGICZ, LGICZ1, ZAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29504. ZACN.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 233208Extracellular Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini255 – 26511Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei266 – 28621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini287 – 29812Extracellular Reviewed predictionAdd
BLAST
Transmembranei299 – 31921Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini320 – 36849Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei369 – 38921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini390 – 41223Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 412387Zinc-activated ligand-gated ion channelPRO_0000317165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi157 ↔ 171 By similarity
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed predictionPRO_5000052473

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ401N2.
PRIDEiQ401N2.

Expressioni

Tissue specificityi

Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.2 Publications

Gene expression databases

BgeeiQ401N2.
CleanExiHS_ZACN.
GenevestigatoriQ401N2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334854.

Structurei

3D structure databases

ProteinModelPortaliQ401N2.
SMRiQ401N2. Positions 52-314.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi224 – 31895Leu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG121521.
HOGENOMiHOG000155757.
HOVERGENiHBG108756.
InParanoidiQ401N2.
KOiK16888.
OMAiLVPCFQV.
OrthoDBiEOG7M98GM.
PhylomeDBiQ401N2.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q401N2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMALWSLLHL TFLGFSITLL LVHGQGFQGT AAIWPSLFNV NLSKKVQESI    50
QIPNNGSAPL LVDVRVFVSN VFNVDILRYT MSSMLLLRLS WLDTRLAWNT 100
SAHPRHAITL PWESLWTPRL TILEALWVDW RDQSPQARVD QDGHVKLNLA 150
LATETNCNFE LLHFPRDHSN CSLSFYALSN TAMELEFQAH VVNEIVSVKR 200
EYVVYDLKTQ VPPQQLVPCF QVTLRLKNTA LKSIIALLVP AEALLLADVC 250
GGLLPLRAIE RIGYKVTLLL SYLVLHSSLV QALPSSSSCN PLLIYYFTIL 300
LLLLFLSTIE TVLLAGLLAR GNLGAKSGPS PAPRGEQREH GNPGPHPAEE 350
PSRGVKGSQR SWPETADRIF FLVYVVGVLC TQFVFAGIWM WAACKSDAAP 400
GEAAPHGRRP RL 412
Length:412
Mass (Da):45,816
Last modified:February 5, 2008 - v2
Checksum:iB894A28F5163723F
GO
Isoform 2 (identifier: Q401N2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-266: AMELEFQAHV...RAIERIGYKV → GADRAGAAGL...VLSGSLRAPL
     267-412: Missing.

Show »
Length:266
Mass (Da):29,616
Checksum:i06C2C8684090C9C8
GO
Isoform 3 (identifier: Q401N2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-126: DILRYTMSSM...TPRLTILEAL → SSVLPRATAL...PPCINPSGDI
     127-412: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:126
Mass (Da):13,299
Checksum:i9F87FF81BAB98B5F
GO

Sequence cautioni

The sequence AAI10598.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAO20969.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence EAW89365.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521A → T.2 Publications
Corresponds to variant rs2257020 [ dbSNP | Ensembl ].
VAR_038483

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 12652DILRY…ILEAL → SSVLPRATALHSHGDCSGSA PCSKARGSGCHGLTPGNHLK VQPPCINPSGDI in isoform 3. VSP_030909Add
BLAST
Alternative sequencei127 – 412286Missing in isoform 3. VSP_030910Add
BLAST
Alternative sequencei182 – 26685AMELE…IGYKV → GADRAGAAGLRRGGGRWGRG TPRSVVQGQGAGQGEGAKAD RRRTPRSVFRAVYPRLRRAA PALPLRPPLEWQPISVLSGS LRAPL in isoform 2. VSP_030911Add
BLAST
Alternative sequencei267 – 412146Missing in isoform 2. VSP_030912Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF512521 mRNA. Translation: AAO20969.1. Different initiation.
AB223030 mRNA. Translation: BAE19924.1.
AK122638 mRNA. No translation available.
AC018665 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89365.1. Different initiation.
CH471099 Genomic DNA. Translation: EAW89366.1.
BC110596 mRNA. No translation available.
BC110597 mRNA. Translation: AAI10598.1. Different initiation.
CCDSiCCDS11740.2. [Q401N2-1]
RefSeqiNP_851321.2. NM_180990.3. [Q401N2-1]
UniGeneiHs.714919.

Genome annotation databases

EnsembliENST00000334586; ENSP00000334854; ENSG00000186919. [Q401N2-1]
ENST00000392503; ENSP00000376291; ENSG00000186919. [Q401N2-3]
ENST00000421794; ENSP00000391936; ENSG00000186919. [Q401N2-3]
ENST00000425015; ENSP00000397489; ENSG00000186919. [Q401N2-2]
GeneIDi353174.
KEGGihsa:353174.
UCSCiuc002jqn.2. human. [Q401N2-1]

Polymorphism databases

DMDMi166991030.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF512521 mRNA. Translation: AAO20969.1 . Different initiation.
AB223030 mRNA. Translation: BAE19924.1 .
AK122638 mRNA. No translation available.
AC018665 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89365.1 . Different initiation.
CH471099 Genomic DNA. Translation: EAW89366.1 .
BC110596 mRNA. No translation available.
BC110597 mRNA. Translation: AAI10598.1 . Different initiation.
CCDSi CCDS11740.2. [Q401N2-1 ]
RefSeqi NP_851321.2. NM_180990.3. [Q401N2-1 ]
UniGenei Hs.714919.

3D structure databases

ProteinModelPortali Q401N2.
SMRi Q401N2. Positions 52-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000334854.

Chemistry

ChEMBLi CHEMBL1628479.
GuidetoPHARMACOLOGYi 587.

Polymorphism databases

DMDMi 166991030.

Proteomic databases

PaxDbi Q401N2.
PRIDEi Q401N2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334586 ; ENSP00000334854 ; ENSG00000186919 . [Q401N2-1 ]
ENST00000392503 ; ENSP00000376291 ; ENSG00000186919 . [Q401N2-3 ]
ENST00000421794 ; ENSP00000391936 ; ENSG00000186919 . [Q401N2-3 ]
ENST00000425015 ; ENSP00000397489 ; ENSG00000186919 . [Q401N2-2 ]
GeneIDi 353174.
KEGGi hsa:353174.
UCSCi uc002jqn.2. human. [Q401N2-1 ]

Organism-specific databases

CTDi 353174.
GeneCardsi GC17P074075.
H-InvDB HIX0027141.
HGNCi HGNC:29504. ZACN.
MIMi 610935. gene.
neXtProti NX_Q401N2.
PharmGKBi PA162409377.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG121521.
HOGENOMi HOG000155757.
HOVERGENi HBG108756.
InParanoidi Q401N2.
KOi K16888.
OMAi LVPCFQV.
OrthoDBi EOG7M98GM.
PhylomeDBi Q401N2.
TreeFami TF315605.

Miscellaneous databases

ChiTaRSi ZACN. human.
GeneWikii Zinc-activated_ion_channel.
GenomeRNAii 353174.
NextBioi 99731.
PROi Q401N2.
SOURCEi Search...

Gene expression databases

Bgeei Q401N2.
CleanExi HS_ZACN.
Genevestigatori Q401N2.

Family and domain databases

Gene3Di 1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
[Graphical view ]
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel class of ligand-gated ion channel is activated by Zn2+."
    Davies P.A., Wang W., Hales T.G., Kirkness E.F.
    J. Biol. Chem. 278:712-717(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, VARIANT THR-152.
  2. "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system."
    Houtani T., Munemoto Y., Kase M., Sakuma S., Tsutsumi T., Sugimoto T.
    Biochem. Biophys. Res. Commun. 335:277-285(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-152.
    Tissue: Thymus.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).

Entry informationi

Entry nameiZACN_HUMAN
AccessioniPrimary (citable) accession number: Q401N2
Secondary accession number(s): Q2TB29, Q6ZWK3, Q86YW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The mouse and rat orthologous proteins do not exist.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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