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Protein

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 481Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticPRO_0000001259
Transit peptidei1 – ?Chloroplast

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei321 – 3211N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ40147.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ40147.
SMRiQ40147. Positions 55-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK01845.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q40147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVNGVGLS WPSKLTKNQT PKWGFSPSHR RCNPSSSSSA TIRMTASVDE
60 70 80 90 100
KKKTFTLEKS EEAFSKAKEL MPGGVNSPVR AFKSVGGQPI IIDSVKGSRM
110 120 130 140 150
RDIDGNEYID YVGSWGPAII GHADDEVLAA LAETMKKGTS FGAPCLLENT
160 170 180 190 200
LAEMVISAVP SIEMVRFVNS GTEACMGVLR LARAFTCRPK IIKFEGCYHG
210 220 230 240 250
HADPFLVKAG SGVATLGLPD SPGVPKAATI DTLTAPYNDI SAVESLFEEH
260 270 280 290 300
KGEIAAVILE PVVGNAGFIP PKLEFLAAIR KITKENDALL IFDEVMTGFR
310 320 330 340 350
LAYGGAQEYF GITPDLTTLG KIIGGGLPVG AYGGRRDIME MVAPAGPMYQ
360 370 380 390 400
AGTLSGNPLA MTAGIHTLKR LQGQGTYEHL DKITAELTQG ILDAGKKTGH
410 420 430 440 450
AMCGGSIRGM FGFFFADGPI YNFSDAKKSD TEKFGRFYRG MLEEGVYFAP
460 470 480
SQFEAGFTSL AHTPEDIQRT VAAAEKVLKQ I
Length:481
Mass (Da):51,413
Last modified:November 1, 1997 - v1
Checksum:i4D7EFC0E32D64BBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39279 mRNA. Translation: AAA81881.1.
PIRiT07034.
RefSeqiNP_001234690.1. NM_001247761.1.
UniGeneiLes.4018.

Genome annotation databases

GeneIDi543967.
KEGGisly:543967.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39279 mRNA. Translation: AAA81881.1.
PIRiT07034.
RefSeqiNP_001234690.1. NM_001247761.1.
UniGeneiLes.4018.

3D structure databases

ProteinModelPortaliQ40147.
SMRiQ40147. Positions 55-481.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ40147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi543967.
KEGGisly:543967.

Phylogenomic databases

KOiK01845.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00668.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A cDNA clone for glutamate 1-semialdehyde 2,1-aminomutase from tomato (Lycopersicon esculentum Mill.)."
    Polking G.F., Hannapel D.J., Gladon R.J.
    Plant Gene Register PGR95-035
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. VFNT Cherry.
    Tissue: Fruit.

Entry informationi

Entry nameiGSA_SOLLC
AccessioniPrimary (citable) accession number: Q40147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 1, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.