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Protein

Xylose isomerase

Gene

XYLA

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mn2+Note: Binds 2 manganese ions per subunit.

pH dependencei

Optimum pH is 7.0-9.0.

Temperature dependencei

Optimum temperature is 60 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei144By similarity1
Metal bindingi275Manganese 1By similarity1
Metal bindingi311Manganese 1By similarity1
Metal bindingi311Manganese 2By similarity1
Metal bindingi314Manganese 2By similarity1
Metal bindingi339Manganese 1By similarity1
Metal bindingi350Manganese 2By similarity1
Metal bindingi352Manganese 2By similarity1
Metal bindingi382Manganese 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:XYLA
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958251 – 479Xylose isomeraseAdd BLAST479

Proteomic databases

PRIDEiQ40082

Expressioni

Gene expression databases

ExpressionAtlasiQ40082 baseline and differential

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ40082
SMRiQ40082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG410IG6W Eukaryota
COG2115 LUCA

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013452 Xylose_isom_bac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02630 xylose_isom_A, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q40082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGELLVLL LASSLCLSAA VAAQETCPAD IGAKCTDAAS DDWEGEFFPG
60 70 80 90 100
IDKINYEGPT SKKPLSYKWY NAEEVILGKK MKDWFRFSVA FWHTFRGTGG
110 120 130 140 150
DPFGAPTKNW PWEDGTNSLA MAKRRMKAHF EFMEKLGVER WCFHDRDIAP
160 170 180 190 200
DGKTLAETNA NLDEIVELAK QLQSETNIKP LWGTAQLFMH PRYMHGAATS
210 220 230 240 250
PEVKVYAYAA AQVKKALEVT HYLGGENYVF WGGREGYQTL LNTDMKRELE
260 270 280 290 300
HLANFLQAAV NHKKKIGFNG TLLIEPKPQE PTKHQYDWDV ATTFSFLQKF
310 320 330 340 350
GLTGEFKINV ECNHATLSGH SCHHELETAR INDILGNIDA NTGDPQVGWD
360 370 380 390 400
TDEFLTDISE ATLIMSSVVK NDGLAPGGFN FYAKLRREST DVEDLFIAHI
410 420 430 440 450
SGMDTMARGR RNVVKLIEDG SLDELVRKRY QSFDTEIGAM IEAGKGDFET
460 470
LEKKALEWGE PTVPSGKQEL AEMLFQSAL
Length:479
Mass (Da):53,614
Last modified:November 1, 1996 - v1
Checksum:i57E6033AFD77A33F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti443 – 468AGKGD…PSGKQ → GSSSFTAQCKYISAPMIVPY DLLLPA in CAA64544 (PubMed:8620879).CuratedAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95257 mRNA Translation: CAA64545.1
X95256 Genomic DNA Translation: CAA64544.1
PIRiS65466

Similar proteinsi

Entry informationi

Entry nameiXYLA_HORVU
AccessioniPrimary (citable) accession number: Q40082
Secondary accession number(s): Q40081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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