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Protein

Xylose isomerase

Gene

XYLA

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mn2+Note: Binds 2 manganese ions per subunit.

pH dependencei

Optimum pH is 7.0-9.0.

Temperature dependencei

Optimum temperature is 60 degrees Celsius.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441By similarity
Metal bindingi275 – 2751Manganese 1By similarity
Metal bindingi311 – 3111Manganese 1By similarity
Metal bindingi311 – 3111Manganese 2By similarity
Metal bindingi314 – 3141Manganese 2By similarity
Metal bindingi339 – 3391Manganese 1By similarity
Metal bindingi350 – 3501Manganese 2By similarity
Metal bindingi352 – 3521Manganese 2By similarity
Metal bindingi382 – 3821Manganese 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:XYLA
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Xylose isomerasePRO_0000195825Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi4513.MLOC_55107.1.

Structurei

3D structure databases

ProteinModelPortaliQ40082.
SMRiQ40082. Positions 45-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG410IG6W. Eukaryota.
COG2115. LUCA.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q40082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGELLVLL LASSLCLSAA VAAQETCPAD IGAKCTDAAS DDWEGEFFPG
60 70 80 90 100
IDKINYEGPT SKKPLSYKWY NAEEVILGKK MKDWFRFSVA FWHTFRGTGG
110 120 130 140 150
DPFGAPTKNW PWEDGTNSLA MAKRRMKAHF EFMEKLGVER WCFHDRDIAP
160 170 180 190 200
DGKTLAETNA NLDEIVELAK QLQSETNIKP LWGTAQLFMH PRYMHGAATS
210 220 230 240 250
PEVKVYAYAA AQVKKALEVT HYLGGENYVF WGGREGYQTL LNTDMKRELE
260 270 280 290 300
HLANFLQAAV NHKKKIGFNG TLLIEPKPQE PTKHQYDWDV ATTFSFLQKF
310 320 330 340 350
GLTGEFKINV ECNHATLSGH SCHHELETAR INDILGNIDA NTGDPQVGWD
360 370 380 390 400
TDEFLTDISE ATLIMSSVVK NDGLAPGGFN FYAKLRREST DVEDLFIAHI
410 420 430 440 450
SGMDTMARGR RNVVKLIEDG SLDELVRKRY QSFDTEIGAM IEAGKGDFET
460 470
LEKKALEWGE PTVPSGKQEL AEMLFQSAL
Length:479
Mass (Da):53,614
Last modified:November 1, 1996 - v1
Checksum:i57E6033AFD77A33F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti443 – 46826AGKGD…PSGKQ → GSSSFTAQCKYISAPMIVPY DLLLPA in CAA64544 (PubMed:8620879).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95257 mRNA. Translation: CAA64545.1.
X95256 Genomic DNA. Translation: CAA64544.1.
PIRiS65466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95257 mRNA. Translation: CAA64545.1.
X95256 Genomic DNA. Translation: CAA64544.1.
PIRiS65466.

3D structure databases

ProteinModelPortaliQ40082.
SMRiQ40082. Positions 45-477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4513.MLOC_55107.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IG6W. Eukaryota.
COG2115. LUCA.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_HORVU
AccessioniPrimary (citable) accession number: Q40082
Secondary accession number(s): Q40081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.