ID   BADH_HORVU              Reviewed;         505 AA.
AC   Q40024;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 56.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
OS   Hordeum vulgare (Barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Pooideae; Triticeae; Hordeum.
OX   NCBI_TaxID=4513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=95195158; PubMed=7888620; DOI=10.1007/BF00020185;
RA   Ishitani M., Nakamura T., Han S.Y., Takabe T.;
RT   "Expression of the betaine aldehyde dehydrogenase gene in barley in
RT   response to osmotic stress and abscisic acid.";
RL   Plant Mol. Biol. 27:307-315(1995).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Peroxisome (Potential).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; D26448; BAA05466.1; -; mRNA.
DR   PIR; S71413; S71413.
DR   UniGene; Hv.61; -.
DR   HSSP; P05091; 1O04.
DR   Gramene; Q40024; -.
DR   BRENDA; 1.2.1.8; 283.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   NAD; Oxidoreductase; Peroxisome.
FT   CHAIN         1    505       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056529.
FT   NP_BIND     239    244       NAD (By similarity).
FT   MOTIF       503    505       Microbody targeting signal (Potential).
FT   ACT_SITE    261    261       Proton acceptor (By similarity).
FT   ACT_SITE    296    296       Nucleophile (By similarity).
FT   SITE        163    163       Transition state stabilizer (By
FT                                similarity).
SQ   SEQUENCE   505 AA;  54290 MW;  C30B40FF22413BB6 CRC64;
     MAAPPAIPRR GLFIGGGWRE PTLGRHIPVI NPATEDTIGD IPAATAEDVE LAVAAGGPVL
     ARRREPWARA SGATRAKYLN AIAAKITGKI AYLALLETVD SGKPKDEAVA DMDDVAACFE
     YYAALAEALD GKQHAPISLP MEEFKTYVLK EPIGVVGLIT PWNYPLLMAT WKVAPALAAG
     CTAVLKPSEL ASLTCLELGA ICEEIGLPSG VLNIITGLGP DAGAPIASHP HVDKIAFTGS
     TATGKTIMTA AAQMVKPVSL ELGGKSPLVT FDDVADIDKA VEWPMLGCFF NGGQVCSATS
     RLLLHEKIAE PFLDRLVEWA KNIKISDPLE EGCRLGSVIS KGQYEQIKKF ISTARSEGAT
     ILHGGDRPKH LGKGFFIEPT INTGVSTSMQ IWREEVFGPV ICVKVFKTES EAVELANDTH
     YGLAGGVISD DLERCERIAK VIHSGIVWKN CSQPTLVQAP WGGNKRSGFG RELGEWGLEN
     YLSVKQVTRY CKDELYGWYQ RPSKL
//