Reviewed, UniProtKB/Swiss-Prot Q40024 (BADH_HORVU)

Names and origin

Protein names	Recommended name:     Betaine aldehyde dehydrogenase       Short name=BADH     EC=1.2.1.8
Organism	Hordeum vulgare (Barley)
Taxonomic identifier	4513 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Pooideae › Triticeae › Hordeum

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	PeroxisomePotential.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Betaine aldehyde dehydrogenase		PRO_0000056529
Regions
	Nucleotide binding	239 – 244	6	NAD By similarity
	Motif	503 – 505	3	Microbody targeting signal Potential
Sites
	Active site	261	1	Proton acceptor By similarity
	Active site	296	1	Nucleophile By similarity
	Site	163	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q40024-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C30B40FF22413BB6	FASTA	505	54,290
	10 20 30 40 50 60 MAAPPAIPRR GLFIGGGWRE PTLGRHIPVI NPATEDTIGD IPAATAEDVE LAVAAGGPVL 70 80 90 100 110 120 ARRREPWARA SGATRAKYLN AIAAKITGKI AYLALLETVD SGKPKDEAVA DMDDVAACFE 130 140 150 160 170 180 YYAALAEALD GKQHAPISLP MEEFKTYVLK EPIGVVGLIT PWNYPLLMAT WKVAPALAAG 190 200 210 220 230 240 CTAVLKPSEL ASLTCLELGA ICEEIGLPSG VLNIITGLGP DAGAPIASHP HVDKIAFTGS 250 260 270 280 290 300 TATGKTIMTA AAQMVKPVSL ELGGKSPLVT FDDVADIDKA VEWPMLGCFF NGGQVCSATS 310 320 330 340 350 360 RLLLHEKIAE PFLDRLVEWA KNIKISDPLE EGCRLGSVIS KGQYEQIKKF ISTARSEGAT 370 380 390 400 410 420 ILHGGDRPKH LGKGFFIEPT INTGVSTSMQ IWREEVFGPV ICVKVFKTES EAVELANDTH 430 440 450 460 470 480 YGLAGGVISD DLERCERIAK VIHSGIVWKN CSQPTLVQAP WGGNKRSGFG RELGEWGLEN 490 500 YLSVKQVTRY CKDELYGWYQ RPSKL

References

[1]	"Expression of the betaine aldehyde dehydrogenase gene in barley in response to osmotic stress and abscisic acid." Ishitani M., Nakamura T., Han S.Y., Takabe T. Plant Mol. Biol. 27:307-315(1995) [PubMed: 7888620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	D26448 mRNA. Translation: BAA05466.1.
PIR	S71413.
UniGene	Hv.61
3D structure databases
HSSP	HSSP built from PDB template 1O04 based on UniProtKB P05091.
ModBase	Search...
Organism-specific databases
Gramene	Q40024.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BADH_HORVU

Accession

Primary (citable) accession number: Q40024

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 4, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)