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Q40024 (BADH_HORVU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase

Short name=BADH
EC=1.2.1.8
OrganismHordeum vulgare (Barley)
Taxonomic identifier4513 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Peroxisome Potential.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Cellular componentPeroxisome
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: UniProtKB-UniPathway

response to abscisic acid

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to salt stress

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to water deprivation

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentcell wall

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

cytosol

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

leucoplast

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

peroxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Betaine aldehyde dehydrogenase
PRO_0000056529

Regions

Nucleotide binding239 – 2446NAD By similarity
Motif503 – 5053Microbody targeting signal Potential

Sites

Active site2611Proton acceptor By similarity
Active site2961Nucleophile By similarity
Site1631Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q40024 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C30B40FF22413BB6

FASTA50554,290
        10         20         30         40         50         60 
MAAPPAIPRR GLFIGGGWRE PTLGRHIPVI NPATEDTIGD IPAATAEDVE LAVAAGGPVL 

        70         80         90        100        110        120 
ARRREPWARA SGATRAKYLN AIAAKITGKI AYLALLETVD SGKPKDEAVA DMDDVAACFE 

       130        140        150        160        170        180 
YYAALAEALD GKQHAPISLP MEEFKTYVLK EPIGVVGLIT PWNYPLLMAT WKVAPALAAG 

       190        200        210        220        230        240 
CTAVLKPSEL ASLTCLELGA ICEEIGLPSG VLNIITGLGP DAGAPIASHP HVDKIAFTGS 

       250        260        270        280        290        300 
TATGKTIMTA AAQMVKPVSL ELGGKSPLVT FDDVADIDKA VEWPMLGCFF NGGQVCSATS 

       310        320        330        340        350        360 
RLLLHEKIAE PFLDRLVEWA KNIKISDPLE EGCRLGSVIS KGQYEQIKKF ISTARSEGAT 

       370        380        390        400        410        420 
ILHGGDRPKH LGKGFFIEPT INTGVSTSMQ IWREEVFGPV ICVKVFKTES EAVELANDTH 

       430        440        450        460        470        480 
YGLAGGVISD DLERCERIAK VIHSGIVWKN CSQPTLVQAP WGGNKRSGFG RELGEWGLEN 

       490        500 
YLSVKQVTRY CKDELYGWYQ RPSKL 

« Hide

References

[1]"Expression of the betaine aldehyde dehydrogenase gene in barley in response to osmotic stress and abscisic acid."
Ishitani M., Nakamura T., Han S.Y., Takabe T.
Plant Mol. Biol. 27:307-315(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26448 mRNA. Translation: BAA05466.1.
PIRS71413.
UniGeneHv.61.

3D structure databases

ProteinModelPortalQ40024.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ40024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneQ40024.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-16787.
UniPathwayUPA00529; UER00386.

Gene expression databases

GenevestigatorQ40024.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBADH_HORVU
AccessionPrimary (citable) accession number: Q40024
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways