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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:cbdbA1742
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001900201 – 312Methionyl-tRNA formyltransferaseAdd BLAST312

Structurei

3D structure databases

ProteinModelPortaliQ3ZZW0
SMRiQ3ZZW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni112 – 115Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZZW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELKIVFMG SPEFALTPLK MLLAEGYDIC GVYTQPDRPA GRGRELCPPP
60 70 80 90 100
VKTLALEHGL AVYQPQSLKK PEEQAFLKEL KPDVIVVAAY GLILPQAVLD
110 120 130 140 150
IPVYGVLNIH PSLLPRYRGA TPVAATLLGG DEWAGVSLMK LEAGLDTGPV
160 170 180 190 200
YSRSMVAIRP EDTTPILADK LAFIGGCMLL ELLSQIPSLP EPKVQDNTQA
210 220 230 240 250
SYFGMVTKEM GLINWQTSAV EIERRVRAFF PWPGVFTTFN QKTLKILEAK
260 270 280 290 300
PRNLGLGLKP SEVRVYEQSR VMVGSASGEL EIIRLQLEGK AGCSAADFVR
310
GQRNFDGVNL GV
Length:312
Mass (Da):34,092
Last modified:September 27, 2005 - v1
Checksum:iC9B2559D8F674C57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ965256 Genomic DNA Translation: CAI83737.1

Genome annotation databases

EnsemblBacteriaiCAI83737; CAI83737; cbdbA1742
KEGGideh:cbdbA1742

Similar proteinsi

Entry informationi

Entry nameiFMT_DEHMC
AccessioniPrimary (citable) accession number: Q3ZZW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 27, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health