ID   AROE_DEHSC              Reviewed;         286 AA.
AC   Q3ZZN3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=cbdbA429;
OS   Dehalococcoides sp. (strain CBDB1).
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=255470;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16116419; DOI=10.1038/nbt1131;
RA   Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.;
RT   "Genome sequence of the chlorinated compound-respiring bacterium
RT   Dehalococcoides species strain CBDB1.";
RL   Nat. Biotechnol. 23:1269-1273(2005).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AJ965256; CAI82630.1; -; Genomic_DNA.
DR   RefSeq; YP_307546.1; -.
DR   GeneID; 3622646; -.
DR   GenomeReviews; AJ965256_GR; cbdbA429.
DR   KEGG; deh:cbdb_A429; -.
DR   NMPDR; fig|255470.3.peg.947; -.
DR   HOGENOM; Q3ZZN3; -.
DR   OMA; Q3ZZN3; FFANAEE.
DR   BioCyc; DSP255470:CBDBA429-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    286       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000058661.
FT   NP_BIND     130    134       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
SQ   SEQUENCE   286 AA;  31313 MW;  E42192AAACE2EA69 CRC64;
     MQTIPDALFG IIGYPVSHSV SPAMQNAAFK HCKLNYLYLT IAAKPEDLQN VIASMRPLNI
     RGLNVTIPHK IEVIKYIDTL DPAAKKIGAV NTIVNENGQL KGYNTDFGGF VRLLEHNRIA
     PAKHRFALLG AGGSAHAISL AICTLGGHLT VLARQEEKAK DLAAKMCLRF KGKAQGLELN
     EANLEETLAE SDIIVNCTPI GMGNLAGQSL IPPRLLRPDL TVIDAIYNPC KTRLLEDAEK
     KGAKIINGLE MLVWQGAMSF EIWTSQKAPF RVMMKEAEMA LDENEK
//