Reviewed, UniProtKB/Swiss-Prot Q3ZZN3 (AROE_DEHSC)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	cbdbA429

Organism

Dehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]

Taxonomic identifier

255470 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000058661
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	70	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3ZZN3-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: E42192AAACE2EA69	FASTA	286	31,313
	10 20 30 40 50 60 MQTIPDALFG IIGYPVSHSV SPAMQNAAFK HCKLNYLYLT IAAKPEDLQN VIASMRPLNI 70 80 90 100 110 120 RGLNVTIPHK IEVIKYIDTL DPAAKKIGAV NTIVNENGQL KGYNTDFGGF VRLLEHNRIA 130 140 150 160 170 180 PAKHRFALLG AGGSAHAISL AICTLGGHLT VLARQEEKAK DLAAKMCLRF KGKAQGLELN 190 200 210 220 230 240 EANLEETLAE SDIIVNCTPI GMGNLAGQSL IPPRLLRPDL TVIDAIYNPC KTRLLEDAEK 250 260 270 280 KGAKIINGLE MLVWQGAMSF EIWTSQKAPF RVMMKEAEMA LDENEK

References

[1]	"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1." Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L. Nat. Biotechnol. 23:1269-1273(2005) [PubMed: 16116419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ965256 Genomic DNA. Translation: CAI82630.1.
RefSeq	YP_307546.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3622646.
GenomeReviews	Gene locus cbdbA429 in contig AJ965256_GR.
KEGG	deh:cbdb_A429.
NMPDR	fig|255470.3.peg.947.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3ZZN3.
OMA	Q3ZZN3. FFANAEE.
Enzyme and pathway databases
BioCyc	DSP255470:CBDBA429-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_DEHSC

Accession

Primary (citable) accession number: Q3ZZN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)