ID   AROD_DEHSC              Reviewed;         222 AA.
AC   Q3ZZN2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=3-dehydroquinate dehydratase;
DE            Short=3-dehydroquinase;
DE            EC=4.2.1.10;
DE   AltName: Full=Type I DHQase;
GN   Name=aroD; OrderedLocusNames=cbdbA430;
OS   Dehalococcoides sp. (strain CBDB1).
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=255470;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16116419; DOI=10.1038/nbt1131;
RA   Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.;
RT   "Genome sequence of the chlorinated compound-respiring bacterium
RT   Dehalococcoides species strain CBDB1.";
RL   Nat. Biotechnol. 23:1269-1273(2005).
CC   -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 3/7.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the type-I 3-dehydroquinase family.
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DR   EMBL; AJ965256; CAI82631.1; -; Genomic_DNA.
DR   RefSeq; YP_307547.1; -.
DR   GeneID; 3622645; -.
DR   GenomeReviews; AJ965256_GR; cbdbA430.
DR   KEGG; deh:cbdb_A430; -.
DR   NMPDR; fig|255470.3.peg.872; -.
DR   HOGENOM; Q3ZZN2; -.
DR   OMA; Q3ZZN2; LAPFTYA.
DR   BioCyc; DSP255470:CBDBA430-MON; -.
DR   GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   HAMAP; MF_00214; -; 1.
DR   InterPro; IPR018508; 3-dehydroquinate_DH_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001381; DHquinase_I.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF01487; DHquinase_I; 1.
DR   ProDom; PD005337; DHquinase_I; 1.
DR   TIGRFAMs; TIGR01093; aroD; 1.
DR   PROSITE; PS01028; DEHYDROQUINASE_I; FALSE_NEG.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Schiff base.
FT   CHAIN         1    222       3-dehydroquinate dehydratase.
FT                                /FTId=PRO_0000325523.
FT   ACT_SITE    112    112       Proton acceptor (By similarity).
FT   ACT_SITE    139    139       Schiff-base intermediate with substrate
FT                                (By similarity).
SQ   SEQUENCE   222 AA;  24476 MW;  594FFEF2CC14371F CRC64;
     MKIPPICCVI TQLPQAETLK KSEGAAFYEL RLDLLGENWR ETAVLLNKPF MATCRRSAEG
     GSFKGNEAER INRLEKAASA GAFMLDIEYS TPNLEEVLGR LRPQAKCLLS HHNFTDTPSA
     AKLKTLLKDM LTHQADIYKV ITTATSINDN INLLNLTKEI PDKKIVAFAM GEPGILSRIL
     CPLAGSPFTY ASLNDGNKSA SGQMTLAQMI EIYRSVNYAN HT
//