Reviewed, UniProtKB/Swiss-Prot Q3ZZN2 (AROD_DEHSC)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate dehydratase
      Short name=3-dehydroquinase
    EC=4.2.1.10
Alternative name(s):
    Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	cbdbA430

Organism

Dehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]

Taxonomic identifier

255470 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325523
Sites
	Active site	112	1	Proton acceptor By similarity
	Active site	139	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZZN2-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 594FFEF2CC14371F	FASTA	222	24,476
	10 20 30 40 50 60 MKIPPICCVI TQLPQAETLK KSEGAAFYEL RLDLLGENWR ETAVLLNKPF MATCRRSAEG 70 80 90 100 110 120 GSFKGNEAER INRLEKAASA GAFMLDIEYS TPNLEEVLGR LRPQAKCLLS HHNFTDTPSA 130 140 150 160 170 180 AKLKTLLKDM LTHQADIYKV ITTATSINDN INLLNLTKEI PDKKIVAFAM GEPGILSRIL 190 200 210 220 CPLAGSPFTY ASLNDGNKSA SGQMTLAQMI EIYRSVNYAN HT

References

[1]	"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1." Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L. Nat. Biotechnol. 23:1269-1273(2005) [PubMed: 16116419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ965256 Genomic DNA. Translation: CAI82631.1.
RefSeq	YP_307547.1.
3D structure databases
HSSP	HSSP built from PDB template 2GPT based on UniProtKB Q9SQT8.
SMR	Q3ZZN2. Positions 1-216.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZZN2.
Genome annotation databases
GeneID	3622645.
GenomeReviews	Gene locus cbdbA430 in contig AJ965256_GR.
KEGG	deh:cbdb_A430.
NMPDR	fig|255470.3.peg.872.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0710.
HOGENOM	HBG072759.
OMA	LAPFTYA.
PhylomeDB	Q3ZZN2.
Enzyme and pathway databases
BioCyc	DSP255470:CBDBA430-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. aroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_DEHSC

Accession

Primary (citable) accession number: Q3ZZN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	September 27, 2005
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)